reserpine hydrochloride
- CAS No.
- 16994-56-2
- Chemical Name:
- reserpine hydrochloride
- Synonyms
- Reserpine HCl;reserpine hydrochloride
- CBNumber:
- CB2938020
- Molecular Formula:
- C33H41ClN2O9
- Molecular Weight:
- 645.13964
- MDL Number:
- MFCD23379918
- MOL File:
- 16994-56-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | ≥25 mg/mL in DMSO; insoluble in H2O; ≥2.74 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| color | Light yellow to yellow |
| FDA UNII | GWN3C4FTI8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
reserpine hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1914 | Reserpine hydrochloride 99.87% | 16994-56-2 | 100mg | $65 | 2026-06-04 | Buy |
| ApexBio Technology | B1270 | Reserpine hydrochloride | 16994-56-2 | 100mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | B1270 | Reserpine hydrochloride | 16994-56-2 | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| ApexBio Technology | B1270 | Reserpine hydrochloride | 16994-56-2 | 200mg | $99 | 2026-05-06 | Buy |
| aablocks | AA00ABIS | Reserpine (hydrochloride) 99% | 16994-56-2 | 1mg | $8 | 2026-05-28 | Buy |
reserpine hydrochloride Chemical Properties, Uses, Production
Uses
Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
Biological Activity
reserpine hydrochloride (serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (vmat).
in vivo
Reserpine can be used in animal modeling to create gastrointestinal ulcer and depression models. Withdrawal from chronic (14 days) but not acute reserpine (48 hours) significantly decreases immobility time (F2,18=3.68, p<0.05) and increases climbing time (F2,18=4.48, p<0.02) in rats, without altering swimming time in the forced swim test (FST) (F2,18=1.78; NS) compared to control animals. A dose of 5 mg/kg body weight of Reserpine significantly increases the urinary excretion of vanillylmandelic acid (VMA). Animals treated with Reserpine excrete more 5-hydroxyindoleacetic acid (5-HIAA) than controls. Reserpine treatment results in dose-dependent hypotension. Compared to controls, doses of 0.5, 1, 5, 10, and 15 μg/kg of Reserpine significantly (p<0.01) reduce blood pressure[1][3].
Administration: 5 mg/kg ip 18 h before sacrifice
Mice: ICR mice male 7 weeks old[5]
Administration: 10 mg/kg ip once daily for 3 days
(2)The level of cancer induction was identified by specific biochemical markers such as serum gastrin level, TBARS, and glutathione followed by histopathological analysis at two-time periods for 8 and 16 week.
Molecular changes: In the reserpine-induced gastric ulcer control mice, the gastric secretion volume was increased, the pH value (1.04) was decreased, the serum cytokine levels of IL-6, IL-12, TNF-α and IFN-γ was increased.
Administration: 0.5 mg/kg ip once per day for 14 days
Mice: C57BL/6 mice male 7 weeks old[8]
Administration: 0.5 mg/kg ip once per day for 10 days
Molecular changes: Reserpine administration significantly increased cortical contents of MDA (malondialdehyde), reduced GSH (glutathione), increased TNF-ɑ and reduced BDNF (brain derived neurotropic factor). Showed a significant decrease in cortical nor-epinephrine (NE), serotonin (5-HT), and dopamine (DA)
References
[1] Antkiewicz-Michaluk L, et al. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54. DOI:10.1016/j.pnpbp.2014.10.009
[2] Hong B, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18(3):659-69. DOI:10.1208/s12248-016-9901-6
[3] Sreemantula S, et al. Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacol. 2004 Nov 16;4:30. DOI:10.1186/1471-2210-4-30
[4] Pfeiffer CJ, et al. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacol. 1980 Feb;61(4):347-53. DOI:10.1016/0014-2999(80)90073-4
[5] Li GJ, et al. Preventive Effect of Polysaccharide of Larimichthys crocea Swim Bladder on Reserpine Induced Gastric Ulcer in ICR Mice. Korean J Physiol Pharmacol. 2014 Apr;18(2):183-90. DOI:10.4196/kjpp.2014.18.2.183
[6] Gupta MB, et al. Mechanism of ulcerogenic activity of reserpine in albino rats. Eur J Pharmacol. 1974 Jul;27(2):269-71. DOI:10.1016/0014-2999(74)90159-9
[7] Park BK, et al. Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression. Biomed Res Int. 2018 Jun 26;2018:5845491. DOI:10.1155/2018/5845491
[8] El-Marasy SA, et al. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chem Biol Interact. 2021 Jan 25;334:109329. DOI:10.1016/j.cbi.2020.109329
reserpine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
reserpine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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