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ChemicalBook >> CAS DataBase List >>4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Structure
4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione structure
CAS No.
2271036-45-2
Chemical Name:
4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms
BUN36452;Poma-PEG2-N3;Pomalidomide-PEG2-C2-azide;Pomalidomide 4'-PEG2-azide;Pomalidomide 4'-PEG2-azideu00A0;Pomalidomide 4''-PEG2-azideu00A0;Pomalidomide-PEG2-C2-azide;4-[2-[2-(2-azidoethoxy)ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber:
CB29441448
Molecular Formula:
C19H22N6O6
Molecular Weight:
430.42
MDL Number:
MFCD32903292
MOL File:
2271036-45-2.mol
Last updated:2025-04-17 18:22:24
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4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Properties

storage temp. 2-8°C
form Solid
pka 10.741±0.40(predicted)
color White to yellow
UNSPSC Code 51471602
NACRES NA.21

4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Uses,Production

Uses

Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

storage

Store at -20°C

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 5060 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13482353728 sales@fdc-chemical.com China 15816 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4838 58
Shanghai SPAR pharmaceutical technology co., LTD 021-000000 admin@jingshipharmatech.com China 9968 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1592 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Xian confluore Biological Technology Co., Ltd. 		58
ShangHai Angti Biotechnology Co., Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
Xi'an Confluore Biological Technology Co., Ltd. 58
Shanghai SPAR pharmaceutical technology co., LTD 58
Jilin Province Woda Biotechnology Co., Ltd. 58

View Lastest Price from 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pomalidomide 4'-PEG2-azide? pictures 2024-11-19 Pomalidomide 4'-PEG2-azide?
2271036-45-2
 US $44.00-98.00 / mg 98.16% 10g TargetMol Chemicals Inc.
Pomalidomide-NH-PEG2-azide pictures 2024-04-02 Pomalidomide-NH-PEG2-azide
2271036-45-2
 US $0.00 / mg 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.
4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BUN36452 Pomalidomide 4' PEG2 azide?,inhibit,Pomalidomide 4'-PEG-2-azide?,Pomalidomide 4'PEG2azide?,Inhibitor,E3 Ligase Ligand-Linker Conjugates Pomalidomide-PEG2-C2-azide Poma-PEG2-N3 Pomalidomide 4'-PEG2-azide Pomalidomide 4'-PEG2-azideu00A0 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- 4-[2-[2-(2-azidoethoxy)ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Pomalidomide 4''-PEG2-azideu00A0 Pomalidomide-PEG2-C2-azide 2271036-45-2