ChemicalBook >> CAS DataBase List >>Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate structure

CAS No.: 139481-69-9

Chemical Name:: Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Synonyms: Candesartan Methyl Ester;Candesartan Impurity 7;candesartan methyl ester imp;Candesartan Cilexetil impurity I;Candesartan methyl ester impurity;candesartan cilexetil impurity1361;Candesartan Cilexetil EP IMpurity I;Candesartan EP Impurity-I (methyl ester);CANDESARTAN INTERMEDIATES(METHYL ESTER C7);Candesartan Cilexetil Impurity 9(EP Impurity I)

CBNumber:: CB2949303

Molecular Formula:: C25H22N6O3

Molecular Weight:: 454.48

MDL Number:: MFCD09263633

MOL File:: 139481-69-9.mol

MSDS File:: SDS

Last updated:2026-05-28 00:53:45

Product description	Number	Pack Size	Price
Candesartan Cilexetil Impurity I Pharmaceutical Secondary Standard; Certified Reference Material	PHR2022	20 mg	$635
Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate	093448	250.00mg	$742
Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate	093448	1.00g	$1647
Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%	AA007Z5Z	1g	$16
Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%	AA007Z5Z	5g	$55
More product size

Request For Quotation

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Properties

Melting point	169-173°C
Boiling point	704.5±70.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid:particulate/powder
pka	4.15±0.10(Predicted)
Major Application	pharmaceutical
InChI	1S/C25H22N6O3/c1-3-34-25-26-21-10-6-9-20(24(32)33-2)22(21)31(25)15-16-11-13-17(14-12-16)18-7-4-5-8-19(18)23-27-29-30-28-23/h4-14H,3,15H2,1-2H3,(H,27,28,29,30)
InChIKey	RBPFEPGTRLLUKI-UHFFFAOYSA-N
SMILES	[nH]1nnc(n1)c2c(cccc2)c3ccc(cc3)C[n]4c5c(nc4OCC)cccc5C(=O)OC
FDA UNII	NG25Z8EW4V
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
REACH Registrations	Active

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2022	Candesartan Cilexetil Impurity I Pharmaceutical Secondary Standard; Certified Reference Material	139481-69-9	20 mg	$635	2026-04-30	Buy
Matrix Scientific	093448	Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate	139481-69-9	250.00mg	$742	2026-05-18	Buy
Matrix Scientific	093448	Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate	139481-69-9	1.00g	$1647	2026-05-18	Buy
aablocks	AA007Z5Z	Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%	139481-69-9	1g	$16	2026-05-28	Buy
aablocks	AA007Z5Z	Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%	139481-69-9	5g	$55	2026-05-28	Buy

Product number	Packaging	Price	Buy
PHR2022	20 mg	$635	Buy
093448	250.00mg	$742	Buy
093448	1.00g	$1647	Buy
AA007Z5Z	1g	$16	Buy
AA007Z5Z	5g	$55	Buy

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Candesartan Methyl Ester (Candesartan Cilexetil EP Impurity I) is an intermediate in the preparation of Candesartan (C175575).

Synthesis

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

139481-44-0

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

139481-69-9

1. Methyl 2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylate (310 g) and toluene (2.48 L) were added to a reactor, followed by tributyltin chloride (737 g), sodium azide (146 g) and tetrabutylammonium bromide (31 g). 2. The reaction mixture was slowly heated to 110 °C and maintained at 110-115 °C for 24 h, during which the progress of the reaction was monitored by TLC. 3. After completion of the reaction, the reaction mixture was cooled to 15 °C and methanol (3.1 L), water (2.17 L) and acetic acid (930 g) were added sequentially. 4. The mixture was stirred at 15-20 °C for 1 h to promote product separation. 5. After addition of toluene (1.24 L), the reaction mixture was filtered at 15-20 °C. 6. the filter cake was washed thoroughly with water (0.93 L) until the pH of the wash solution reached 5.5-7.0 to completely remove the acid. 7. The filter cake was washed again with toluene (0.62 L) and dried by suction filtration. 8. The product was air dried at 50-55 °C to give methyl 2-ethoxy-1-[[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole]-7-carboxylate. Yield: 290 g (85%).

IC 50

AT2 Receptor: 0.11 μM (IC₅₀)

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 15, p. 2182 - 2195
[2] Patent: WO2005/51929, 2005, A1. Location in patent: Page/Page column 18
[3] Patent: US2009/203920, 2009, A1. Location in patent: Page/Page column 4
[4] Patent: EP1420016, 2004, A1. Location in patent: Page 19
[5] Patent: WO2009/157001, 2009, A2. Location in patent: Page/Page column 3

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate synthesis

Synthesis of Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate from 1-Methyl-3-nitrophthalate

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Preparation Products And Raw materials

Raw materials

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate Azilsartan pharMaceutical interMediate methyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)methyl)amino)-3-nitrobenzoate BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER

Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate methyl 2-(azidocarbonyl)-3-nitrobenzoate 1-Methyl-3-nitrophthalate Methyl 2-ethoxybenzimidazole-7-carboxylate 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

3-Nitrophthalic acid

1of3

Preparation Products

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Suppliers

Global( 150)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3997	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8742	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15074	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9653	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58

Supplier	Advantage
career henan chemical co	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
Shanghai UCHEM Inc.	58
AFINE CHEMICALS LIMITED	58
changzhou huayang technology co., ltd	58
sgtlifesciences pvt ltd	58

View Lastest Price from Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 139481-69-9		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2022-09-29	Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 139481-69-9	$28.00-30.00	1Kg	99.0% up	50 tons per month	Xinxiang Hongqi District Houyuan Trading Co.,Ltd
2020-02-26	Candesartan Methyl Ester 139481-69-9	$1.00	1KG	99%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
139481-69-9
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
139481-69-9
$28.00-30.00
99.0% up
Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Candesartan Methyl Ester
139481-69-9
$1.00
99%+
Shaanxi Dideu Medichem Co. Ltd

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Spectrum

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate(139481-69-9)¹HNMR

139481-69-9(Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate)Related Search:

Candesartan cilexetil Trityl candesartan cilexetil Candesartan Methyl Ester Desethyl Analog N-Trityl Candesartan Ethyl Ester 5-(phenylazo)salicylic acid

CV 15959 CANDESARTAN-D5 Candesartan Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid ethyl ester

BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER Methyl 2-ethoxybenzimidazole-7-carboxylate Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate

Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate CANDESARTAN CILEXETIL-D11 O-Desetheyl Candesartan Ethyl Ester

1of4

Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-ca methyl 1-((2,-(1H-tetrazol-5-yl)-[1,1,-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7 Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate ETHYL2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)METHYL]BENZIMIDAZOLE-7-CARBOXYLATE thyl-2-ethoxy-1-[[2'-(1Htetrazol-5-yl-)methyl]benzimidazole]-7-carboxylate Candesartan Methyl Ester 2-ethoxy-4-ethyl-1-{[4-phenyl-3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]Methyl}-1H-1,3-benzodiazole-7-carboxylate 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid Methyl Ester Candesartan Cilexetil EP IMpurity I Candesartan Cilexetil impurity I 2-Ethoxy-1-[[2-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester Candesartan Impurity 7 Candesartan Cilexetil Impurity 9(EP Impurity I) 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methyl ester CANDESARTAN INTERMEDIATES(METHYL ESTER C7) Candesartan Cilexetil EP Impurity I (Candesartan Methyl Ester) Candesartan methyl ester impurity candesartan methyl ester imp Methyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Meth... candesartan cilexetil impurity1361 Candesartan Cilexetil EP Impurity IQ: What is Candesartan Cilexetil EP Impurity I Q: What is the CAS Number of Candesartan Cilexetil EP Impurity I Q: What is the storage condition of Candesartan Cilexetil EP Impurity I Q: What are the applications of Candesartan Cilexetil EP Impurity I Candesartan Cilexetil Impurity 9(Candesartan Cilexetil EP Impurity I) Methyl 1-[[2’-(5-Tetrazolyl)-4-biphenylyl]methyl]-2-ethoxybenzimidazole-7-carboxylate Methyl 2-ethoxy-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]benzoimidazole-7-carboxylate Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 2-Ethoxy-1-[[2'-(2H-Tetrazol-5-yl)[1,1'-Biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylicacidMethylEster Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (Candesartan Cilexetil Impurity) Candesartan EP Impurity-I (methyl ester) methyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate thyl-2-ethoxy-1-[[2’-(1Htetrazol-5-yl-)methyl]benzimidazole]-7-carboxylate Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (Cande Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (Candesartan Methyl Ester) 139481-69-9 C25H22N6O3 Aromatics Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals