U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
- CAS No.
- 87151-85-7
- Chemical Name:
- U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
- Synonyms
- Spiradoline;Espiradolina;Spiradolinum;U-62066 solid;Spiradolinum [latin];Espiradolina [spanish];Spiradoline mesylate salt;U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST;Benzeneacetamide, 3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, rel-;(±)-(5α,7α,8β)-3,4-dichloro-n-methyl-n-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide mesylate salt
- CBNumber:
- CB2972242
- Molecular Formula:
- C22H30Cl2N2O2
- Molecular Weight:
- 425.39
- MDL Number:
- MFCD00153876
- MOL File:
- 87151-85-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 563.070±50.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.272±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble14mg/mL |
| form | solid |
| pka | 9.144±0.20(predicted) |
| color | white |
| Water Solubility |
H2O: 14mg/mL methanol: insoluble |
| InChIKey | FHEZDPDAYTVKKG-JLBKCEDKSA-N |
| SMILES | CS(O)(=O)=O.CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccc(Cl)c(Cl)c4 |
| FDA UNII | N18ZH0M4NP |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | U105 | U-62066 solid | 87151-85-7 | 25mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | U105 | U-62066 solid | 87151-85-7 | 100mg | $380 | 2026-04-30 | Buy |
| TRC | U100230 | U62066 | 87151-85-7 | 5mg | $130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000786 | U-62066 95.00% | 87151-85-7 | 25MG | $626.15 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000786 | U-62066 95.00% | 87151-85-7 | 100MG | $789.51 | 2021-12-16 | Buy |
U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Chemical Properties, Uses, Production
Uses
Analgesic.
Uses
U 62066 is a selective κ-opioid agonist. It exhibits analgesic, diuretic and antitussive properties.
Biological Activity
U-62066, also known as spiradoline, is a highly selective K opioid receptor agonist. It exhibits analgesic and diuretic effects. Antitussive property of U-62066 is observed in rats.
in vivo
Spiradoline (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline. In stressed animals, the socially suppressing effects of the Spiradoline are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066[1].
| Animal Model: | Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint[1] |
| Dosage: | 0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4mg/kg |
| Administration: | Subcutaneous injection; once |
| Result: | Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested. |
