Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Sivopixant

Sivopixant

Sivopixant Structure
Sivopixant structure
CAS No.
2414285-40-6
Chemical Name:
Sivopixant
Synonyms
Sivopixant;Sivopixant, 10 mM in DMSO;S 600918,S600918,ligation,analgesic,P2XRs,inhibit,pain,P2X Receptor,Inhibitor,sciatic,nerve,selective;(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-{[4-(pyridin-2-yloxy)phenyl]imino}-1,3,5-triazinan-1-yl]-2-methylpropanoic acid;(2S)-3-[(4E)-3-[(4-Chlorophenyl)methyl]-2,6-dioxo-4-[4-(2-pyridyloxy)phenyl]imino-1,3,5-triazinan-1-yl]-2-methyl-propanoic acid - [AC79855];1,3,5-Triazine-1(2H)-propanoic acid, 3-[(4-chlorophenyl)methyl]tetrahydro-α-methyl-2,6-dioxo-4-[[4-(2-pyridinyloxy)phenyl]imino]-, (αS,4E)-
CBNumber:
CB29733855
Molecular Formula:
C25H22ClN5O5
Molecular Weight:
507.93
MDL Number:
MFCD34567696
MOL File:
2414285-40-6.mol
Last updated:2025-09-23 08:43:30
Request For Quotation

Sivopixant Properties

Boiling point 674.5±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
pka 4.55±0.10(Predicted)
form Solid
color White to off-white
FDA UNII S0N1VEG94I

Sivopixant Chemical Properties,Uses,Production

Uses

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].

in vivo

Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg)[1].

References

[1] Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384. DOI:10.1016/j.bmcl.2021.128384

Sivopixant Preparation Products And Raw materials

Raw materials

Preparation Products

Sivopixant Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3503 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4669 55
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9800 58
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2881924765@qq.com China 7892 58
Wuhan Augda Biotechnology Co., Ltd 15071299552 262933239@qq.com China 6884 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 2881924050@qq.com China 9985 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Chunchuang (Wuhan) Technology Co., Ltd 58
Hubei Kele Fine Chemical Co., Ltd 58
Wuhan Augda Biotechnology Co., Ltd 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from Sivopixant manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sivopixant pictures 2025-09-22 Sivopixant
2414285-40-6
 US $89.00-197.00 / mg 99.21% 10g TargetMol Chemicals Inc.
  • Sivopixant pictures
  • Sivopixant
    2414285-40-6
  • US $89.00-197.00 / mg
  • 99.21%
  • TargetMol Chemicals Inc.

Sivopixant Spectrum

Sivopixant(2414285-40-6)1HNMR
Sivopixant S 600918,S600918,ligation,analgesic,P2XRs,inhibit,pain,P2X Receptor,Inhibitor,sciatic,nerve,selective 1,3,5-Triazine-1(2H)-propanoic acid, 3-[(4-chlorophenyl)methyl]tetrahydro-α-methyl-2,6-dioxo-4-[[4-(2-pyridinyloxy)phenyl]imino]-, (αS,4E)- (2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-{[4-(pyridin-2-yloxy)phenyl]imino}-1,3,5-triazinan-1-yl]-2-methylpropanoic acid Sivopixant, 10 mM in DMSO (2S)-3-[(4E)-3-[(4-Chlorophenyl)methyl]-2,6-dioxo-4-[4-(2-pyridyloxy)phenyl]imino-1,3,5-triazinan-1-yl]-2-methyl-propanoic acid - [AC79855] 2414285-40-6