VitaMin D4
- CAS No.
- 511-28-4
- Chemical Name:
- VitaMin D4
- Synonyms
- VITAMIN D;COLECALCIFEROL;CALCIOL;RACUMIN D;Duphafral;Vtamin D4;vitamin D4;VITAMINE D4;OLEOVITAMIN D3;CHOLECALCIFEROLUM
- CBNumber:
- CB3104866
- Molecular Formula:
- C28H46O
- Molecular Weight:
- 398.66
- MDL Number:
- MFCD18781880
- MOL File:
- 511-28-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 22,23-Dihydroergocalciferol ≥97.0% (HPLC) | 88815 | 1mg | $281 |
| Vitamin D4 ≥98% | 22471 | 500μg | $117 |
| Vitamin D4 ≥98% | 22471 | 1mg | $222 |
| VitaminD4 | V680000 | 1mg | $185 |
| Vitamin D | 474334 | 1mg | $918 |
| More product size | |||
| Melting point | 83-86 °C(lit.) |
|---|---|
| alpha | D18 +89.3° (c = 0.47 in acetone) |
| Boiling point | 504.9±29.0 °C(Predicted) |
| Density | 0.96 |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform |
| form | Powder |
| pka | 14.74±0.20(Predicted) |
| color | Off-white to light yellow |
| Stability | Hygroscopic, Temperature Sensitive |
| InChIKey | DIPPFEXMRDPFBK-JPWDPSJFSA-N |
| SMILES | [C@H]1(O)CCC(=C)/C(=C\C=C2/CCC[C@@]3(C)[C@@]/2([H])CC[C@@H]3[C@H](C)CC[C@H](C)C(C)C)/C1 |
| FDA 21 CFR | 172.380; 184.1950; 104.20; 107.10; 107.100 |
| CAS DataBase Reference | 511-28-4(CAS DataBase Reference) |
| EWG's Food Scores | 1-4 |
| FDA UNII | KN41X73N6C |
| NCI Dictionary of Cancer Terms | vitamin D |
| NCI Drug Dictionary | vitamin D |
| ATC code | A11CC05,A11CC55 |
| UNSPSC Code | 12352200 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311-H330-H372 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 24/25-26-48/25 | |||||||||
| Safety Statements | 28-36/37 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | VS2900000 | |||||||||
| F | 8-10-23 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 3 Oral STOT RE 1 Oral |
|||||||||
| NFPA 704 |
|
VitaMin D4 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 88815 | 22,23-Dihydroergocalciferol ≥97.0% (HPLC) | 511-28-4 | 1mg | $281 | 2023-01-07 | Buy |
| Cayman Chemical | 22471 | Vitamin D4 ≥98% | 511-28-4 | 500μg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 22471 | Vitamin D4 ≥98% | 511-28-4 | 1mg | $222 | 2024-03-01 | Buy |
| TRC | V680000 | VitaminD4 | 511-28-4 | 1mg | $185 | 2021-12-16 | Buy |
| Usbiological | 474334 | Vitamin D | 511-28-4 | 1mg | $918 | 2021-12-16 | Buy |
VitaMin D4 Chemical Properties,Uses,Production
Synthesis in Skin
Once vitamin D, enters the circulation, it is transported to the liver where it is hydroxylated to 25-hydroxyvitamin D3 (25-(OH)D3). 25-Hydroxyvitamin D3 is the major circulating form of vitamin D3 and its determination is often used to measure the vitamin D status of a patient. Although 1 ,25-(OH)2D3 has a marked effect on inhibiting proliferation of cultured human fibroblasts and keratinocytes and inducing terminal differentiation of cultured keratinocytes, there is no evidence that a deficiency in this hormone will increase proliferative activity in human skin. Thus, it would appear that 1,25-(OH)D3 is not a major regulator of dermal and epidermal proliferation and differentiation. Despite the fact that 1,25-(OH)2D3 is not a major participant in the regulation of epidermal differentiation, the observations that 1,25-(OH)D3 can inhibit the hyperproliferative activity of epidermal cells in patients with psoriasis is intriguing. It should be noted that patients with psoriasis have a normal metabolism of vitamin D to 25-hydroxyvitamin D and 1 ,25-(OH)2D3.24 Therefore, 1 ,25-(OH)2D3 and its analogs hold promise as unique pharmacologic agents for treating hyperproliFerative disorders of the skin such as psoriasis.
Description
Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.
Chemical Properties
Pale Yellow Oil
Uses
Vitamin D4 is the active analogue of Vitamin D.
Definition
ChEBI: Vitamin D4 is it is present in mushrooms. It has a role as a fungal metabolite. It is a vitamin D and a seco-ergostane.
Biological Functions
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.
Source
Vitamin D is a 9,10-secosteroid and 6 forms have been identified. The importance of vitamin D in bone (calcium homeostasis) is well established, and vitamin D has been the subject of increased attention in recent years for its role in muscle function, immunology, heart and cardiovascular disease, cancer, and insulin secretion. The vitamin D4 precursor 22,23-dihydroergosterol was present in all mushroom composites. The levels were not correlated with vitamin D4, but differed among species. Enoki mushrooms had a notably higher 22,23-dihydroergosterol content, with an average of 16.5 mg/100g compared to 4.49–8.89 mg/ 100 g in other types of mushrooms.
VitaMin D4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 | Amyjiyunzen@yeah.net | China | 672 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 1287 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
View Lastest Price from VitaMin D4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-10 | VitaMin D4
511-28-4
|
US $5.00-0.50 / KG | 1KG | 99% hplc | 500TONS | Wuhan JiyunZen Tech Co., Ltd. | |
 |
2025-12-22 | Vitamin D4
511-28-4
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-12-01 | VitaMin D4
511-28-4
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- VitaMin D4
511-28-4
- US $5.00-0.50 / KG
- 99% hplc
- Wuhan JiyunZen Tech Co., Ltd.
-
- Vitamin D4
511-28-4
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- VitaMin D4
511-28-4
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
