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ChemicalBook >> CAS DataBase List >>N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide

N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide

N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide Structure
N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide structure
CAS No.
1922098-90-5
Chemical Name:
N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide
Synonyms
CCG257081;CCG 257081;CCG-257081;3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(4-pyridinyl)benzoyl]-;N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide
CBNumber:
CB310764531
Molecular Formula:
C24H19ClF3N3O2
Molecular Weight:
473.87
MDL Number:
MFCD34600840
MOL File:
1922098-90-5.mol
Last updated:2025-04-17 18:22:24
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N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide Properties

Boiling point 689.1±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
form Solid
pka 13.69±0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H315-H302-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide Chemical Properties,Uses,Production

Description

CCG-257081 is an inihibitor of Rho/MRTF/SRF pathway. CCG-257081 has shown efficacy in preventing bleomycin-induced fibrosis in several mouse models.

Uses

MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis[1].

References

[1] Larsen Scott D, et al. Preparation of substituted piperidine-3-carboxamides as inhibitors of myocardin-related transcription factor and serum response factor (MTRF/SRF)-mediated gene transcription. World Intellectual Property Organization, WO2016073847 A2. 2016-05-12.

N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Nanjing Shizhou Biology Technology Co.,Ltd 13675144456 alan.chow@synzest.com China 9470 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19965 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 55710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyri din-4-yl)benzoyl]piperidine-3-carboxamide CCG 257081 CCG257081 CCG-257081 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(4-pyridinyl)benzoyl]- 1922098-90-5