DX3-213B
- CAS No.
- 2749555-66-4
- Chemical Name:
- DX3-213B
- Synonyms
- DX3-213B;DX3-213B ，E1139;DX3-213B, 10 mM in DMSO;DX3-213B New
- CBNumber:
- CB311047336
- Molecular Formula:
- C20H28F2N2O5S2
- Molecular Weight:
- 478.57
- MDL Number:
- MOL File:
- 2749555-66-4.mol
| solubility |
DMF:2.0(Max Conc. mg/mL);4.18(Max Conc. mM) DMSO:3.0(Max Conc. mg/mL);6.27(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);4.18(Max Conc. mM) |
|---|---|
| form | A crystalline solid |
| color | White to off-white |
| InChI | InChI=1/C20H28F2N2O5S2/c1-15(2)30(26,27)17-5-7-18(8-6-17)31(28,29)24-11-3-4-16(14-24)19(25)23-12-9-20(21,22)10-13-23/h5-8,15-16H,3-4,9-14H2,1-2H3/t16-/s3 |
| InChIKey | HLSJMSNPBRGRGL-QEIABERDNA-N |
| SMILES | S(C1C=CC(S(=O)(=O)C(C)C)=CC=1)(N1CCC[C@@H](C(N2CCC(F)(F)CC2)=O)C1)(=O)=O |&1:17,r| |
DX3-213B Chemical Properties,Uses,Production
Description
DX3-213B is a potent Oxidative Phosphorylation Inhibitor (MIA PaCa-2 GI50 = 11 nM) for the Treatment of Pancreatic Cancer. DX3-213B disrupts adenosine triphosphate (ATP) generation, inhibits complex I function, and results in the growth inhibition of pancreatic cancer cells in the low nanomolar range. Importantly, the oral administration of DX3-213B resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.
Uses
DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer[1].
References
[1] Xue D, et al. Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer. J Med Chem. 2022;65(4):3404-3419. DOI:10.1021/acs.jmedchem.1c01934
DX3-213B Preparation Products And Raw materials
Raw materials
Preparation Products
DX3-213B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3210 | 58 |
| Shanghai Taopu Industrial Co., LTD | 159-00573766 18018507602 | 394643792@qq.com | China | 4303 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2680 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5839 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13011 | 58 |
| R&D Systems, Inc | 18003437475 | rdname@qq.com | China | 6960 | 58 |
