Ethyl 4-bromocrotonate
- CAS No.
- 37746-78-4
- Chemical Name:
- Ethyl 4-bromocrotonate
- Synonyms
- Ethyl (E)-4-bromobut-2-enoate;Ethyl (E)-4-bromo-2-butenoate;(E)-Ethyl 4-broMobut-2-enoate;Neratinib Impurity 26;thyl 4-bromocrotonate;ETHYL 4-BROMOCROTONATE;Ethyl-4-bromocrotanate;4- broMoethyl crotonate;Ethylbromocrotonatepract;Ethyl gamma-bromocrotonate
- CBNumber:
- CB3111015
- Molecular Formula:
- C6H9BrO2
- Molecular Weight:
- 193.04
- MDL Number:
- MFCD00000247
- MOL File:
- 37746-78-4.mol
| Boiling point | 94-95 °C/12 mmHg (lit.) |
|---|---|
| Density | 1.402 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 207 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Liquid |
| Specific Gravity | 1.402 |
| color | Clear light yellow to brown |
| Water Solubility | Insoluble in water. |
| BRN | 1721388 |
| Stability | Light Sensitive |
| InChIKey | FHGRPBSDPBRTLS-ONEGZZNKSA-N |
| CAS DataBase Reference | 37746-78-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Butenoic acid, 4-bromo-, ethyl ester, (E)-(37746-78-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-24/25 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19-23 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29161995 | |||||||||
| NFPA 704 |
|
Ethyl 4-bromocrotonate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E13830 | Ethyl 4-bromocrotonate 75%, technical grade | 37746-78-4 | 5g | $53.2 | 2025-07-31 | Buy |
| Sigma-Aldrich | E13830 | Ethyl 4-bromocrotonate 75%, technical grade | 37746-78-4 | 25g | $157 | 2025-07-31 | Buy |
| TRC | E676685 | (E)-Ethyl4-Bromobut-2-enoate(>80%) | 37746-78-4 | 1g | $50 | 2021-12-16 | Buy |
| TRC | E676685 | (E)-Ethyl4-Bromobut-2-enoate(>80%) | 37746-78-4 | 5g | $70 | 2021-12-16 | Buy |
| AK Scientific | C269 | Ethyl 4-bromocrotonate | 37746-78-4 | 5g | $27 | 2021-12-16 | Buy |
Ethyl 4-bromocrotonate Chemical Properties,Uses,Production
Chemical Properties
clear yellow liquid
Uses
Ethyl 4-bromocrotonate is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.
Synthesis
623-70-1
37746-78-4
General procedure for the synthesis of ethyl (E)-4-bromobut-2-enoate from ethyl crotonate: To a round-bottomed flask containing ethyl (2E)-but-2-enoate (10.9 g, 87.6 mmol) and carbon tetrachloride (100 mL), N-bromosuccinimide (NBS, 17 g, 96 mmol) and azobisisobutyronitrile (AIBN, 4.3 g, 26 mmol). The reaction mixture was stirred at 80 °C for 12 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (DCM) and washed sequentially with saturated sodium bicarbonate solution, water and brine. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give ethyl (E)-4-bromobut-2-enoate (7.5 g, 44% yield) as an oil.
References
[1] Journal of the American Chemical Society, 2001, vol. 123, # 21, p. 4966 - 4973
[2] Patent: WO2017/100668, 2017, A1. Location in patent: Page/Page column 150
[3] Patent: WO2018/103058, 2018, A1. Location in patent: Page/Page column 150
[4] Bulletin de la Societe Chimique de France, 1966, p. 1315 - 1324
[5] Journal of Organometallic Chemistry, 1973, vol. 60, p. 209 - 217
Ethyl 4-bromocrotonate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12397 | 58 |
View Lastest Price from Ethyl 4-bromocrotonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-24 | Ethyl 4-bromocrotonate
37746-78-4
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2019-07-11 | Ethyl 4-bromocrotonate
37746-78-4
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Ethyl 4-bromocrotonate
37746-78-4
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 4-bromocrotonate
37746-78-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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