(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
- CAS No.
- 210354-22-6
- Chemical Name:
- (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
- Synonyms
- GW274150;GW274150 (GW-274150;Acetylcysteine Impurity 4;4-(2-acetamidoethylthio)-2-aminobutanoic acid;S-[2-[(1-iminoethyl)amino]ethyl]-L-Homocysteine;4-(2-acetamidoethylsulfanyl)-2-aminobutanoicacid;L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-;(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID;(2S)-2-amino-4-[(2-ethanimidamidoethyl)sulfanyl]butanoic acid
- CBNumber:
- CB3116696
- Molecular Formula:
- C8H17N3O2S
- Molecular Weight:
- 219.3
- MDL Number:
- MFCD07363946
- MOL File:
- Mol file
| Boiling point | 392.3±52.0 °C(Predicted) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 2.22±0.10(Predicted) |
| color | White to off-white |
| Water Solubility | Water : ≥ 62 mg/mL (282.72 mM) |
| FDA UNII | 0ZZF1V8G63 |
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5419 | GW274150 | 210354-22-6 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-5419 | GW274150 | 210354-22-6 | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-5419 | GW274150 | 210354-22-6 | 25mg | $700 | 2021-12-16 | Buy |
| ChemScene | CS-5419 | GW274150 | 210354-22-6 | 50mg | $1000 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611586 | GW274150 | 210354-22-6 | 100mg | $1208.7 | 2021-12-16 | Buy |
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Chemical Properties,Uses,Production
Uses
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2].
in vivo
GW274150 is a long-acting (5 h half-life in rats) iNOS inhibitor and is able to inhibit LPS-mediated increase in plasma NO2-, NO3- levels 14 h after single intraperitoneal dose (ED50=3 mg/kg)[2].GW274150 (intraperitoneal injection; 2.5, 5, and 10 mg/kg; before carrageenan injection) reduces the degree of lung injury induced by carrageenan in a dose-related fashion. Oedema formation and PMNs infiltration in the pleural cavity are also significantly attenuated in a dose-related manner in rats[2].GW274150 (oral adminstration; 30 mg/kg; twice daily; 7 days) leads to significant neuroprotection, However, it displays a bell-shaped neuroprotective profile, being ineffective at high doses in 6-OHDA rat model of Parkinson disease (PD)[3].
| Animal Model: | SD-rat[2] |
| Dosage: | 2.5, 5 and 10 mg/kg; single dose |
| Administration: | Intraperitoneal?injection 5 min before carrageenan injection |
| Result: | Exerted a protective role in an acute model of inflammation, carrageenan-induced lung injury. |
IC 50
iNOS
References
[1] Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12. DOI:10.1038/sj.bjp.0706168
[2] Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb DOI:10.1038/sj.bjp.0705683
[3] Broom L, et al. Neuroprotection?by the?selective?iNOS?inhibitor?GW274150?in a?model?of?Parkinson?disease.Free Radic Biol Med.?2011 Mar 1;50(5):633-40. DOI:10.1016/j.freeradbiomed.2010.12.026
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3003 | 58 |
| Shanghai Synmedia Chemical Co., Ltd. | 021-38681880 13817889927 | sales@synmedia-chem.com | China | 249 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
