L-Pyroglutaminol
- CAS No.
- 17342-08-4
- Chemical Name:
- L-Pyroglutaminol
- Synonyms
- PYROGLUTAMINOL;(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;PGLU-OL;ARBA-002;L-Pyr-OL;H-PYR-OL;EOS-61026;H-PGLU-OL;L-PYROGLUTAMINOL;(S)-PyroglutaMinol
- CBNumber:
- CB3117668
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00077792
- MOL File:
- 17342-08-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (S)-5-(Hydroxymethyl)-2-pyrrolidinone 97% | 366366 | 5g | $483 |
| (S)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC) | H0867 | 1g | $26 |
| (S)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC) | H0867 | 5g | $72 |
| (S)-Pyroglutaminol | TRC-P997525-5G | 5g | $167 |
| (S)-Pyroglutaminol | TRC-P997525-50G | 50g | $1115 |
| More product size | |||
| Melting point | 79-80 °C(lit.) |
|---|---|
| alpha | 30 º (C=2, ETOH) |
| Boiling point | 147-149°C 0,06mm |
| Density | 1.1808 (rough estimate) |
| refractive index | 31 ° (C=5, EtOH) |
| Flash point | 147-149°C/0.06m |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Ethanol, Methanol |
| pka | 14.35±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to light yellow |
| optical activity | [α]20/D +30°, c = 2 in ethanol |
| Water Solubility | Soluble in water. |
| BRN | 4657914 |
| InChI | 1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8)/t4-/m0/s1 |
| InChIKey | HOBJEFOCIRXQKH-BYPYZUCNSA-N |
| SMILES | OC[C@@H]1CCC(=O)N1 |
| CAS DataBase Reference | 17342-08-4(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29051990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
L-Pyroglutaminol price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 366366 | (S)-5-(Hydroxymethyl)-2-pyrrolidinone 97% | 17342-08-4 | 5g | $483 | 2023-06-20 | Buy |
| TCI Chemical | H0867 | (S)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC) | 17342-08-4 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | H0867 | (S)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC) | 17342-08-4 | 5g | $72 | 2026-04-30 | Buy |
| TRC | TRC-P997525-5G | (S)-Pyroglutaminol | 17342-08-4 | 5g | $167 | 2026-06-03 | Buy |
| TRC | TRC-P997525-50G | (S)-Pyroglutaminol | 17342-08-4 | 50g | $1115 | 2026-06-03 | Buy |
L-Pyroglutaminol Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystals or
Uses
(S)-Pyroglutaminol (cas# 17342-08-4) is a compound useful in organic synthesis.
Synthesis
7149-65-7
17342-08-4
General procedure for the synthesis of (S)-(+)-5-hydroxymethyl-2-pyrrolidinone from ethyl (S)-5-oxopyrrolidine-2-carboxylate: compound III was synthesized as follows: firstly, LiCl (18 mmol) was added to the reaction flask and dissolved in anhydrous tetrahydrofuran (15 ml). The temperature of the reaction system was controlled at -15 to -10°C. Subsequently, potassium borohydride (18 mmol) was added to the system and the reaction was stirred for 30 minutes. In another reaction flask, compound II (9 mmol) was dissolved in anhydrous tetrahydrofuran (20 ml) and cooled to -15 to -10 °C. Then, the previously prepared reaction solution was slowly added dropwise to this system. After the dropwise addition, the reaction was slowly warmed up to room temperature for 2 hours. The reaction process was monitored by TLC to confirm the complete reaction of the raw materials. Next, saturated ammonium chloride solution (5 ml) was added slowly dropwise to the reaction system and stirred for 30 minutes. The reaction mixture was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to give compound III (8.55 mmol) in 95% yield.
References
[1] Patent: CN107304179, 2017, A. Location in patent: Paragraph 0033; 0036-0037; 0055; 0058;
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 4, p. 437 - 445
[3] Tetrahedron, 1996, vol. 52, # 10, p. 3719 - 3740
[4] Patent: WO2015/181676, 2015, A1. Location in patent: Page/Page column 170-171
[5] Journal of Organic Chemistry, 1992, vol. 57, # 7, p. 2158 - 2160
L-Pyroglutaminol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hainan Bonsen New Technology Co., LTD | +86-17384938934 +86-15310476930 | sales@newbs.com.cn | China | 45 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-15680023009 | ni@enlaibio.com | China | 1103 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7240 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1796 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
View Lastest Price from L-Pyroglutaminol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-14 | L-Pyr-Ol
17342-08-4
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-07-10 | L-Pyroglutaminol
17342-08-4
|
1KG | 98% | 100KG | Hainan Bonsen New Technology Co., LTD | ||
 |
2025-05-23 | L-Pyroglutaminol
17342-08-4
|
$150.00 | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- L-Pyr-Ol
17342-08-4
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Pyroglutaminol
17342-08-4
- 98%
- Hainan Bonsen New Technology Co., LTD
-
- L-Pyroglutaminol
17342-08-4
- $150.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
