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N-(2-HYDROXYETHYL)NITOTINAMIDE

N-(2-HYDROXYETHYL)NITOTINAMIDE structure

CAS No.: 6265-73-2

Chemical Name:: N-(2-HYDROXYETHYL)NITOTINAMIDE

Synonyms: N-(2-hydroxyethyl)pyridine-3-carboxamide;SG-86;Nicorandil Impurity 1;Nicondil EP Impurity B;Hydroxyethylnicotinamide;Nicorandil EP Impurity B;Nicorandil EP Impurity 2;N-(2-hydroxyethyl)nicotinamide;N-(2-HYDROXYETHYL)NITOTINAMIDE;N-(2-Hydroxyethyl)-3-Pyridine Carboxamide

CBNumber:: CB31177348

Molecular Formula:: C8H10N2O2

Molecular Weight:: 166.18

MDL Number:: MFCD00547113

MOL File:: 6265-73-2.mol

MSDS File:: SDS

Last updated:2026-05-28 00:55:57

Product description	Number	Pack Size	Price
N-(2-Hydroxyethyl)pyridine-3-carboxamide	EME00383	1 g	$606
N-(2-Hydroxyethyl)nitotinamide	456933	250mg	$368
N-(2-Hydroxyethyl)nitotinamide	456933	1g	$638
N-(2-Hydroxyethyl)nicotinamide	TRC-H942365-5G	5g	$1546
N-(2-Hydroxyethyl)nicotinamide	TRC-H942365-250MG	250mg	$157
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N-(2-HYDROXYETHYL)NITOTINAMIDE Properties

Melting point	92 °C
Boiling point	185-195 °C(Press: 0.4-0.6 Torr)
Density	1.212±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	12.94±0.46(Predicted)
color	White to Pale Yellow
InChI	InChI=1S/C8H10N2O2/c11-5-4-10-8(12)7-2-1-3-9-6-7/h1-3,6,11H,4-5H2,(H,10,12)
InChIKey	SJZLOWYUGKIWAK-UHFFFAOYSA-N
SMILES	C1=NC=CC=C1C(NCCO)=O
FDA UNII	MHH3UT8GRP
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

N-(2-HYDROXYETHYL)NITOTINAMIDE price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	EME00383	N-(2-Hydroxyethyl)pyridine-3-carboxamide	6265-73-2	1 g	$606	2026-04-30	Buy
Usbiological	456933	N-(2-Hydroxyethyl)nitotinamide	6265-73-2	250mg	$368	2026-06-03	Buy
Usbiological	456933	N-(2-Hydroxyethyl)nitotinamide	6265-73-2	1g	$638	2026-06-03	Buy
TRC	TRC-H942365-5G	N-(2-Hydroxyethyl)nicotinamide	6265-73-2	5g	$1546	2026-06-03	Buy
TRC	TRC-H942365-250MG	N-(2-Hydroxyethyl)nicotinamide	6265-73-2	250mg	$157	2026-06-03	Buy

Product number	Packaging	Price	Buy
EME00383	1 g	$606	Buy
456933	250mg	$368	Buy
456933	1g	$638	Buy
TRC-H942365-5G	5g	$1546	Buy
TRC-H942365-250MG	250mg	$157	Buy

N-(2-HYDROXYETHYL)NITOTINAMIDE Chemical Properties,Uses,Production

Uses

N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.

Synthesis

59-67-6

141-43-5

6265-73-2

The general procedure for the synthesis of N-(2-hydroxyethyl)-3-pyridinecarboxamide from nicotinic acid and 2-aminoethanol was as follows: suspension of nicotinic acid (0.385 g, 3.13 mmol) in anhydrous toluene (15 mL), addition of thionyl chloride (455 μL, 6.26 mmol), and refluxing of the reaction mixture for 4 hours at 140 °C. After cooling, a clarified solution was obtained and the solvent was removed in vacuum. The solid residue was washed three times with ether, followed by the addition of fresh anhydrous toluene (15 mL) and ethanolamine (756 μL, 12.52 mmol). The mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed under vacuum and the solid residue was purified by silica gel column chromatography using dichloromethane/methanol (9.2:0.8) as eluent. The final white solid product N-(2-hydroxyethyl)-3-pyridinecarboxamide (450 mg, 86% yield) was obtained with a melting point of 205 °C. The 1H NMR (300 MHz, DMSO-d6) data of the product were as follows: δ 9.00 (s, 1H, NH), 8.68 (m, 2H, Ar-H), 8.17 (d, 1H, Ar-H), 7.60 (m, 1H, Ar-H), 4.74 (m, 1H, OH), 3.51 (m, 2H, CH2), 3.36 (m, 2H CH2).

References

[1] Patent: WO2006/92204, 2006, A1. Location in patent: Page/Page column 16-17
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5134 - 5147
[3] Archiv der Pharmazie, 2003, vol. 336, # 10, p. 445 - 455

N-(2-HYDROXYETHYL)NITOTINAMIDE Preparation Products And Raw materials

Raw materials

Ethyl nicotinate Nicotinic acid Monoethanolamine Thionyl chloride Toluene

Preparation Products

N-(2-HYDROXYETHYL)NITOTINAMIDE Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16505	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14320	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	951	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3968	58
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050	sean.lv@synzest.com	China	323	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	029-81140587	sales@yutbon.com	China	452	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23506	58
sgtlifesciences pvt ltd	+91-8790379245	dj@sgtlifesciences.com	China	12351	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Nanjing Shizhou Biotechnology Co., Ltd	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
sgtlifesciences pvt ltd	58

View Lastest Price from N-(2-HYDROXYETHYL)NITOTINAMIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-02	N-(2-Hydroxyethyl)Nitotinamide 6265-73-2	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-04-04	N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2020-01-13	N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2	$1.00	1g	98%	100KG	Career Henan Chemical Co

N-(2-Hydroxyethyl)Nitotinamide
6265-73-2
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

N-(2-HYDROXYETHYL)NITOTINAMIDE
6265-73-2
98%
Henan Aochuang Chemical Co.,Ltd.

N-(2-HYDROXYETHYL)NITOTINAMIDE
6265-73-2
$1.00
98%
Career Henan Chemical Co

N-(2-HYDROXYETHYL)NITOTINAMIDE Spectrum

N-(2-HYDROXYETHYL)NITOTINAMIDE(6265-73-2)¹HNMR

6265-73-2(N-(2-HYDROXYETHYL)NITOTINAMIDE)Related Search:

p-Nicorandil Nicorandil Impurity 2 N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE nicopholine N-Nicotinoylglycine

Nicorandil METHYL 2-[[(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO]ACETATE METHYL 4-(METHYLTHIO)-2-([[2-(METHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)BUTANOATE N-[2-(METHYLTHIO)NICOTINOYL]-L-LEUCINE METHYL 2-([[2-(ETHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOATE

(2S)-2-([(2-CHLOROPYRIDIN-3-YL)CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOIC ACID DIETHYL 2-([(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO)MALONATE MORPHOLINO[6-(1H-PYRAZOL-1-YL)-3-PYRIDINYL]METHANONE 3-methyl-2-[(pyridin-3-ylcarbonyl)amino]pentanoic acid (2-METHYL-1,6-NAPHTHYRIDIN-3-YL)MORPHOLINOMETHANONE

ETHYL 2-METHYL-5-OXO-6-(2-([3-(TRIFLUOROMETHYL)BENZOYL]OXY)ETHYL)-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE ETHYL 6-(2-HYDROXYETHYL)-2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE N-(PYRIDIN-3-YLCARBONYL)METHIONINE

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SG-86 Nicorandil Impurity 1 Nicorandil EP Impurity B N-(2-HYDROXYETHYL)NITOTINAMIDE N-(2-hydroxyethyl)nicotinamide N-(2-Hydroxyethyl)-3-Pyridine Carboxamide Nicorandil Impurity 2(Nicorandil EP Impurity B) 3-Pyridinecarboxamide,N-(2-hydroxyethyl)- N-(2-HYDROXYETHYL)NITOTINAMIDE ISO 9001：2015 REACH Nicorandil EP Impurity B/Nicorandil Amide Imp Hydroxyethylnicotinamide Nicorandil EP Impurity 2 N-(2-Hydroxyethyl)pyridine-3-carboxamide N-(2-hydroxyethyl)nitotinamide (Intermediate of Nicorandil) Nicondil EP Impurity B N-(2-hydroxyethyl)pyridine-3-carboxamide 6265-73-2