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ChemicalBook >> CAS DataBase List >>2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- Structure
2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- structure
CAS No.
2242957-52-2
Chemical Name:
2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-
Synonyms
2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-
CBNumber:
CB312220187
Molecular Formula:
C17H15F3N2O
Molecular Weight:
320.31
MDL Number:
MOL File:
2242957-52-2.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:59
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2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- Properties

Boiling point 474.1±45.0 °C(Predicted)
Density 1.329±0.06 g/cm3(Predicted)
pka 5.49±0.18(Predicted)
form Solid
color White to off-white

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0134201 UCB-J 99.62% 2242957-52-2 5mg $542 2026-06-04 Buy
ChemScene CS-0134201 UCB-J 99.62% 2242957-52-2 10mg $921 2026-06-04 Buy
ChemScene CS-0134201 UCB-J 99.62% 2242957-52-2 25mg $1787 2026-06-04 Buy
ChemScene CS-0134201 UCB-J 99.62% 2242957-52-2 50mg $2817 2026-06-04 Buy
ChemScene CS-0134201 UCB-J 99.62% 2242957-52-2 100mg $4550 2026-06-04 Buy
Product number Packaging Price Buy
CS-0134201 5mg $542 Buy
CS-0134201 10mg $921 Buy
CS-0134201 25mg $1787 Buy
CS-0134201 50mg $2817 Buy
CS-0134201 100mg $4550 Buy

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- Chemical Properties, Uses, Production

Uses

UCB-J is a positron emission tomography (PET) radioligand for the synaptic vesicle protein 2A (SV2A)[1][2][3][4].

in vivo

UCB-J exhibits high free fraction (0.46 ± 0.02) and metabolizes at a moderate rate (39% ± 5% and 24% ± 3% parent remaining at 30 and 90 min) in plasma[3].
UCB-J displays high uptake and fast kinetics in the monkey brain[3].
When the animal is pretreated with UCB-J (150 μg/kg, iv), the whole brain SUV decreases to the same level as centrum semiovale, indicating the in vivo binding specificity of [18F]7 to SV2A[4].

References

[1] Jol Mercier, et al. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands. ChemMedChem. 2014 Apr;9(4):693-8. DOI:10.1002/cmdc.201300482
[2] Aline Delva, et al. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease. Mov Disord. 2020 Aug 7. DOI:10.1002/mds.28216
[3] Nabeel B Nabulsi, et al. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May;57(5):777-84. DOI:10.2967/jnumed.115.168179
[4] Zhengxin Cai, et al. Synthesis and Preclinical Evaluation of an 18 F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [ 18 F]SynVesT-2. ACS Chem Neurosci. 2020 Feb 19;11(4):592-603. DOI:10.1021/acschemneuro.9b00618

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Supplier Advantage
RD International Technology Co., Limited 58

2242957-52-2 (2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-) Related Search:

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2-Pyrrolidinone, 1-[(3-methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)- 2242957-52-2