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ChemicalBook >> CAS DataBase List >>3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Structure
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride structure
CAS No.
762240-92-6
Chemical Name:
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
Synonyms
Sitagliptin hydrochloride;3-(trifluoromethyl)-5,6,7,8-tetrahydro;Sitagliptin Triazole Hydrochloride;3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-;3-(Trifluoromethyl)-5;Sitagliptin interMediate A;3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride;3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch;5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride;5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%
CBNumber:
CB31228965
Molecular Formula:
C6H7F3N4.ClH
Molecular Weight:
228.6
MDL Number:
MFCD09817638
MOL File:
762240-92-6.mol
MSDS File:
SDS
Last updated:2026-05-28 00:56:59
Product description Number Pack Size Price
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride >98.0%(HPLC) T2998 1g $54
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride >98.0%(HPLC) T2998 5g $158
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 290999 25g $336
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 290999 50g $460
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 290999 100g $644
More product size
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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Properties

Melting point 236-246°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
InChI InChI=1S/C6H7F3N4.ClH/c7-6(8,9)5-12-11-4-3-10-1-2-13(4)5;/h10H,1-3H2;1H
InChIKey AQCSCRYRCRORET-UHFFFAOYSA-N
SMILES C12=NN=C(C(F)(F)F)N1CCNC2.[H]Cl
CAS DataBase Reference 762240-92-6(CAS DataBase Reference)
FDA UNII Y0OF5KV5KA

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN2811
HS Code  2933599577
REACH Registrations Active
NFPA 704
1
2 0

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T2998 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride >98.0%(HPLC) 762240-92-6 1g $54 2026-04-30 Buy
TCI Chemical T2998 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride >98.0%(HPLC) 762240-92-6 5g $158 2026-04-30 Buy
Usbiological 290999 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 762240-92-6 25g $336 2026-06-03 Buy
Usbiological 290999 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 762240-92-6 50g $460 2026-06-03 Buy
Usbiological 290999 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, HCl Asreported 762240-92-6 100g $644 2026-06-03 Buy
Product number Packaging Price Buy
T2998 1g $54 Buy
T2998 5g $158 Buy
290999 25g $336 Buy
290999 50g $460 Buy
290999 100g $644 Buy

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Chemical Properties,Uses,Production

Description

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a pharmaceutical intermediate compound used in the preparation of Sitagliptin phosphate. Sitagliptin is an oral hypoglycaemic agent, a dipeptidyl peptidase-4 inhibitor, which is used in the treatment of type 2 diabetes.

Chemical Properties

White Solid or White to Light yellow powder to crystal

Uses

Sitagliptin intermediate.

Synthesis

A suspension of N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide (27.3 g, 0.13 mol) in 110 mL of methanol was WARMED TO 55 ℃. 37% Hydrochloric acid (11.2 mL, 0.14 mol) was added over 15 min at this temperature. During the addition, all solids dissolved, resulting in a clear solution. The reaction was aged for 30 min. The solution was cooled to 20 ℃ and aged at this temperature until a seed bed formed (10 min to 1 h). 300 ML of MTBE was charged at 20 ℃ over 1 h. The resulting slurry was cooled to 2 ℃, aged for 30 min and filtered. Solids were washed with 50 mL of ethanol: MTBE (1: 3) and dried under vacuum at 45 ℃. Yield of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride was 26.7 g (99.5 area wt% pure by HPLC).

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride synthesis

763105-70-0
762240-92-6
Synthesis of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride from N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Sitagliptin N-Boc IMpurity

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Suppliers

Global( 606)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan BJM Pharm Inc
027-52341919 13545198479 sales03@benjaminpharmchem.com China 584 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Shandong Huisheng Import & Export Co., Ltd. 		+86-13176845580 da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Anhui Zhongda Biotechnology Co., Ltd 		+8615689548120 linda@zhongda-biotech.com China 193 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 sales@sjar-tech.com China 529 58
Guangzhou Tosun Pharmaceutical Ltd 		+86-020-61855200-902 +8618124244216 info@upharm.cn China 897 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Supplier Advantage
Wuhan BJM Pharm Inc
58
Shenzhen Nexconn Pharmatechs Ltd
58
Hebei Yanxi Chemical Co., Ltd. 		58
Shandong Huisheng Import & Export Co., Ltd. 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Guangzhou Tosun Pharmaceutical Ltd 		58
Capot Chemical Co.,Ltd. 		60

View Lastest Price from 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride pictures 2026-06-05 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6
 1KG 97.5%-101.0% 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride pictures 2026-06-05 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6
 0.99 RongNa Biotechnology Co.,Ltd
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride pictures 2026-05-28 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
762240-92-6
 $1.00 1KG 99% 10000 S&Y Biochem Co.,Ltd

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Spectrum

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride(762240-92-6)1HNMR

762240-92-6(3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride)Related Search:

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (+/-)1-(1-Naphthyl)ethylamine Sitagliptin Impurity 27 Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin N-Sulfate
Sitagliptin Defuoro IMpurity 4 Sitagliptin Impurity 26 Meldrum's Acid Fenasi Sitagliptin phosphate
Prazosin 2-Methylpyrazine Terazosin hydrochloride Terazosin Doxazosin
Tetramethylpyrazine Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-

1of4

3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3- 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride Sitagliptin Triazole Hydrochloride Sitagliptin Impurity 64 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98% Sitagliptin interMediate A 1,2,4-Triazolo[4,3-a]pyrazine,5,6,7,8-tetrahydro-3-(trifluoroMethyl)-,hydrochloride(1:1) 3 - (three fluorinated Methyl) - 5,6,7,8 - four hydrogen - triazole 4-trichlorobenzene [1] and [4, 3 - alpha] pyrazine hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetra-hydro-[1,2,4]-Triazolo-[4,3-a]-pyrazine hydrochloride Salt Sitagliptin side chain 5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride Sitagliptin Intermediates Impurity 3-CF3-5,6,7,8-H4-[1,2,4]triazolo[4,3a]pyrazine HCl Triazolepine hydrochloride 3-(Trifluoromethyl)-5 3-a]pyrazine hydrochloride Sitagliptin Impurity 20 HCl 3-(trifluoromethyl)-5,6,7,8-r Sitagliptin Triazole Impurity HCl 3-(trifluoromethyl)-5,6,7,8-tetrahydro Sitagliptin-16 3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch Sitagliptin Triazole (Impurity C) Sitaglliptin phosphate intermediate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine Hydrochloride 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine Monohydrochloride 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Monohydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorid 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(trifluoromethyl)-5,6,7,8-retrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazine HCl 3-(TrifluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyr 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 5,8-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Sitagliptin Intermediate 2 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoroMethyl)-, hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride （Sitagliptin） Sitagliptin triazole impurity hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a]pyrazine hydrochloride [TTTP] pyrazine HCl Cas762240-92-6 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine Hydrochloride Sitagliptin Impurity 20 Hydrochloride Urgent? 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride ISO 9001：2015 REACH 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazolio [4,3-a] pyrazine 3-(terifluoromethyl)-7-[(2,4,5-trifluorophenyl]acetyl]-5,6,7,8- tetrahydro[1,2,4]triazole[4,3-a]pyrazine Sitagliptin Triazole HCL 3-trifluoro methyl-[1,2,4]triazole[4,3-a]piperazine hydrochl... 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride / Sitagliptin Intermediate SitagliptinImpurity20-d4 4-(Trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4] Triazolo[4,3-a]pyrazine Hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride,[1,2,4]Triazolo[4,3-a]Pyrazine Hydrochloride 762240-92-6 Sitagliptin 3-(Trifluoromethyl)-5,6,7,8-tetrahydro- triazolopyrazine Hydrochloride (Triazole) 3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIZOLO[4,3-A]PYRAZINE HYDROCHLORIDE 3- (Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.41 triazolo[4,3-a] pyrazine hydrochloride,TRIAZOLE 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazole and [4,3-a] pyrazine hydrochloride 3-(triuoromethyl)-5,6,7,8-tetrahydro- [1,2,4]triazolo[4,3-a]pyrazine hydrochloride