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2-Cyano-3-chloropyridine

2-Cyano-3-chloropyridine structure

CAS No.: 38180-46-0

Chemical Name:: 2-Cyano-3-chloropyridine

Synonyms: 3-Chloropicolinonitrile;oro-2-cyanopyridine;2-Cyano-3-chloropyri;3-CHLORO-2-CYANOPYRIDINE;2-CYANO-3-CHLOROPYRIDINE;3-Chloro-2-cyanopyridine >3-Chloro-2-cyanopyridine ,95%;3-CHLOROPYRIDINE-2-CARBONITRILE;3-CHLORO-2-PYRIDINECARBONITRILE;2-Pyridinecarbonitrile, 3-chloro-

CBNumber:: CB3127818

Molecular Formula:: C6H3ClN2

Molecular Weight:: 138.55

MDL Number:: MFCD03788834

MOL File:: 38180-46-0.mol

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
3-Chloro-2-cyanopyridine >98.0%(GC)	C3022	1g	$16
3-Chloro-2-cyanopyridine >98.0%(GC)	C3022	5g	$42
2-Cyano-3-chloropyridine	C8397-02	250mg	$425
2-Cyano-3-chloropyridine	C962500	1g	$195
2-Cyano-3-chloropyridine	C962500	5g	$880
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2-Cyano-3-chloropyridine Properties

Melting point	81-83°C
Boiling point	100°C/3mmHg(lit.)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Methanol
pka	-2.60±0.10(Predicted)
form	Solid
color	Light Yellow
InChI	InChI=1S/C6H3ClN2/c7-5-2-1-3-9-6(5)4-8/h1-3H
InChIKey	YDPLFBIGFQFIDB-UHFFFAOYSA-N
SMILES	C1(C#N)=NC=CC=C1Cl
CAS DataBase Reference	38180-46-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H302-H311-H315-H319-H332-H335-H301

Precautionary statements

P301+P310-P280h-P305+P351+P338-P309-P310

Hazard Codes

T,Xi

Risk Statements

25-36/37/38-20/21/22

Safety Statements

45-36/37-22

RIDADR

2811

HazardClass

6.1

HazardClass

IRRITANT-HARMFUL

PackingGroup

Ⅲ

HS Code

29333990

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

2-Cyano-3-chloropyridine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3022	3-Chloro-2-cyanopyridine >98.0%(GC)	38180-46-0	1g	$16	2025-07-31	Buy
TCI Chemical	C3022	3-Chloro-2-cyanopyridine >98.0%(GC)	38180-46-0	5g	$42	2025-07-31	Buy
Usbiological	C8397-02	2-Cyano-3-chloropyridine	38180-46-0	250mg	$425	2021-12-16	Buy
TRC	C962500	2-Cyano-3-chloropyridine	38180-46-0	1g	$195	2021-12-16	Buy
TRC	C962500	2-Cyano-3-chloropyridine	38180-46-0	5g	$880	2021-12-16	Buy

Product number	Packaging	Price	Buy
C3022	1g	$16	Buy
C3022	5g	$42	Buy
C8397-02	250mg	$425	Buy
C962500	1g	$195	Buy
C962500	5g	$880	Buy

2-Cyano-3-chloropyridine Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.

Synthesis

7677-24-9

38180-46-0

3-Chloro-2-cyanopyridine (44A, 2.59 g, 20 mmol) was used as starting material and mixed with trimethylmethylsilyl cyanide (5.95 g, 60 mmol), triethylamine (Et3N, 4.05 g, 40 mmol), and acetonitrile (20 mL) in a 250 mL three-necked round-bottom flask. The reaction mixture was refluxed under nitrogen protection for 6 h. Complete consumption of raw materials was confirmed by HPLC analysis. Upon completion of the reaction, the cooled reaction mixture was concentrated under reduced pressure to give a brown semi-solid. The semi-solid was extracted by partitioning with 3N Na2CO3 aqueous solution and dichloromethane (CH2Cl2). The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 5% ether (Et2O)/dichloromethane (CH2Cl2) as eluent, and the target product 44B was finally obtained as a white crystalline solid (1.84 g, 67% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.37 (dd, J = 4.7, 8.4 Hz, 1H), 7.73 (dd, J = 1.4, 8.2 Hz, 1H), 8.47 (dd, J = 1.3, 4.6 Hz, 1H); LC/MS analysis showed m/z 139 [M + H]+.

References

[1] Patent: US2004/19063, 2004, A1
[2] Patent: US2004/181064, 2004, A1

2-Cyano-3-chloropyridine Preparation Products And Raw materials

Raw materials

Trimethylsilyl cyanide Acetonitrile Hydrogen peroxide 3-Chloropyridine Potassium carbonate

Triethylamine Acetic acid ZINC CYANIDE 2-CYANO-3-HYDROXYPYRIDINE 3-CHLOROPYRIDINE N-OXIDE

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Preparation Products

Ethanone, 1-(3-methoxy-2-pyridinyl)- (9CI) 3-(3-Methoxyphenyl)picolinonitrile

2-Cyano-3-chloropyridine Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 2-Cyano-3-chloropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-10-15	2-Cyano-3-chloropyridine 38180-46-0	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2020-01-19	2-Cyano-3-chloropyridine 38180-46-0	US $3.00 / KG	1KG	98%	1kg,5kg,50kg	Career Henan Chemical Co
2020-01-03	2-Cyano-3-chloropyridine	US $1.00 / KG	1KG	99%	10000KGS	Career Henan Chemical Co

2-Cyano-3-chloropyridine
38180-46-0
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Cyano-3-chloropyridine
38180-46-0
US $3.00 / KG
98%
Career Henan Chemical Co

2-Cyano-3-chloropyridine
US $1.00 / KG
99%
Career Henan Chemical Co

2-Cyano-3-chloropyridine Spectrum

2-Cyano-3-chloropyridine(38180-46-0)¹HNMR

38180-46-0(2-Cyano-3-chloropyridine)Related Search:

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5-Bromo-3-nitropyridine-2-carbonitrile 2-Cyano-3-fluoropyridine 5-bromo-3-methylpicolinonitrile 2-Cyano-3,5-difluoropyridine 3-bromo-5-chloropyridine-2-carbonitrile

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2-Cyano-3-chloropyri 3-Chloropicolinonitrile 3-Chloro-2-cyanopyridine ,95% 3-Chloro-2-cyanopyridine, 3-Chloropicolinonitrile 3-CHLORO-2-PYRIDINECARBONITRILE 3-CHLORO-2-CYANOPYRIDINE 3-CHLOROPYRIDINE-2-CARBONITRILE 2-CYANO-3-CHLORO PYRIDINE / 3-CHLORO-2-CYANOPYRIDINE 2-CYANO-3-CHLOROPYRIDINE 3-Chloro-2-cyanopyridine > oro-2-cyanopyridine 2-Pyridinecarbonitrile, 3-chloro- 2-Cyano-3-chloropyridine ISO 9001：2015 REACH 38180-46-0 Heterocycle-Pyridine series Nucleotides and Nucleosides Pyridines Bases & Related Reagents Pyridines, Pyrimidines, Purines and Pteredines pharmacetical Pyridine series Pyridine Nucleotides