2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- CAS No.
- 256519-10-5
- Chemical Name:
- 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- Synonyms
- 4-fluoro-1,3-dihydrobenzimidazol-2-one;4-Fluoro-1H-benzo[d]imidazol-2(3H)-one;4-Fluoro-1,3-dihydrobenzoiMidazol-2-one;2H-Benzimidazol-2-one, 4-fluoro-1,3-dihydro-;4-Fluoro-2,3-dihydro-1h-1,3-benzodiazol-2-one;4-fluoro-1,3-dihydro-2H-benzo[d]imidazol-2-one;2H-BENZO[D]IMIDAZOL-2-ONE,4-FLUORO-1,3-DIHYDRO-;4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one;2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- CBNumber:
- CB31284859
- Molecular Formula:
- C7H5FN2O
- Molecular Weight:
- 152.13
- MDL Number:
- MFCD18814470
- MOL File:
- 256519-10-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC909355 | 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one 97% | 256519-10-5 | 250mg | $79 | 2026-06-04 | Buy |
| Apolloscientific | PC909355 | 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one 97% | 256519-10-5 | 1g | $199 | 2026-06-04 | Buy |
| Activate Scientific | AS46556 | 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one 96% | 256519-10-5 | 1g | $173 | 2026-06-04 | Buy |
| Activate Scientific | AS46556 | 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one 96% | 256519-10-5 | 5g | $601 | 2026-06-04 | Buy |
| aablocks | AA00BIJ3 | 4-Fluoro-2,3-dihydro-1h-1,3-benzodiazol-2-one 98% | 256519-10-5 | 100mg | $21 | 2026-05-28 | Buy |
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Chemical Properties, Uses, Production
Synthesis
18645-88-0
530-62-1
256519-10-5
a) 3-Fluorobenzene-1,2-diamine (0.600 g, 4.76 mmol) was dissolved in tetrahydrofuran (THF, 14.82 mL), and 1,1'-carbonyldiimidazole (0.848 g, 5.23 mmol) was added slowly at room temperature. The reaction mixture was stirred overnight at room temperature and then warmed up to 50 °C to continue the reaction for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, a methanol solution of ammonia (1.5 mL) was added and stirring was continued for 30 minutes. Subsequently, the reaction mixture was diluted with water (40 mL), the resulting brown solid was collected by filtration, washed with water and dried under vacuum to afford 4-fluoro-1H-benzo[d]imidazol-2(3H)-one (0.700 g, 97% yield). The product could be used in subsequent steps without further purification.1H NMR (400 MHz, DMSO-d6) δ 6.81 (2H, ddd), 6.88-6.95 (1H, m), 10.82 (1H, s), 11.08 (1H, s); Mass Spectrum (ES-) m/z: 151.19 [M-H]-.
References
[1] Patent: US2011/306613, 2011, A1. Location in patent: Page/Page column 31
[2] Patent: US8138168, 2012, B1. Location in patent: Page/Page column 481-482
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd | 18210788515; 18210788515 | zhuzixin999@163.c0m | China | 4999 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai ZiHao Pharmaceutical Co., Ltd. | 021-13482410-12 13482410112; | 362383684@qq.com | China | 751 | 58 |
| Shanghai Baoyisheng Biotechnology Co., LTD | 15221020695 ; | 502277408@qq.com | China | 456 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Amel Pharmatech Corporation | 027-888-4366503 13986279625 | sales@amelpharmatech.com | China | 4826 | 58 |
