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ChemicalBook >> CAS DataBase List >>L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]-

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]-

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- Structure
L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- structure
CAS No.
2227350-99-2
Chemical Name:
L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]-
Synonyms
VC-PAB-exatecan;Val-Cit-PAB-Exatecan;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate;L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]-
CBNumber:
CB313197749
Molecular Formula:
C43H49FN8O9
Molecular Weight:
840.9
MDL Number:
MOL File:
2227350-99-2.mol
MSDS File:
SDS
Last updated:2026-05-28 00:57:12
Request For Quotation

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- Properties

Boiling point 1203.4±65.0 °C(Predicted)
Density 1.45±0.1 g/cm3(Predicted)
pka 10.74±0.40(Predicted)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H311-H331
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0647137 Val-Cit-PAB-Exatecan 99.79% 2227350-99-2 5mg $325 2026-06-04 Buy
ChemScene CS-0647137 Val-Cit-PAB-Exatecan 99.79% 2227350-99-2 10mg $520 2026-06-04 Buy
ChemScene CS-0647137 Val-Cit-PAB-Exatecan 99.79% 2227350-99-2 25mg $1040 2026-06-04 Buy
ChemScene CS-0647137 Val-Cit-PAB-Exatecan 99.79% 2227350-99-2 50mg $1679 2026-06-04 Buy
ChemScene CS-0647137 Val-Cit-PAB-Exatecan 99.79% 2227350-99-2 100mg $2654 2026-06-04 Buy
Product number Packaging Price Buy
CS-0647137 5mg $325 Buy
CS-0647137 10mg $520 Buy
CS-0647137 25mg $1040 Buy
CS-0647137 50mg $1679 Buy
CS-0647137 100mg $2654 Buy

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- Chemical Properties, Uses, Production

Uses

Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker[1].

IC 50

Camptothecins

References

[1] Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262. DOI:10.1016/S1470-2045(16)30030-4

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- Suppliers

Global Suppliers ( 13)
Supplier Tel Email Country ProdList Advantage
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Shanghai Send Pharmaceutical Technology Co., Ltd. 021-58088081 18317173152 Hailey@shsendpharm.com China 843 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 811 58
Shanghai Ruipu Medical Technology Co., Ltd 15895968936 1018762393@qq.com China 9992 58
Tianjin Kaite Pharmaceutical Co. LTD 13821592195 15522388980 523122940@qq.com China 308 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Shanghai Huici Pharmaceutical Technology Co., LTD 133-31922809 19372841038 lixing@pharmahuici.com China 853 58
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 ET-market@chemextension.com China 38900 58
YJ Pharma 13962794339 Sales@yucarepharma.com China 302 58
Supplier Advantage
Hangzhou J&H Chemical Co., Ltd. 59
Shanghai Send Pharmaceutical Technology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai Haoyuan Chemexpress Co., Ltd. 58
Shanghai Ruipu Medical Technology Co., Ltd 58
Tianjin Kaite Pharmaceutical Co. LTD 58
Bide Pharmatech Ltd. 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
YJ Pharma 58

2227350-99-2 (L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]-) Related Search:

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L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]carbonyl]oxy]methyl]phenyl]- 4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamate Val-Cit-PAB-Exatecan VC-PAB-exatecan 2227350-99-2 C43H49FN8O9