AFD 21
- CAS No.
- 99465-44-8
- Chemical Name:
- AFD 21
- Synonyms
- NS-2;AFD 21;NS-2 Class 1 antiarrhythmic agent
- CBNumber:
- CB31361699
- Molecular Formula:
- C28H39NO5
- Molecular Weight:
- 469.62
- MDL Number:
- MOL File:
- 99465-44-8.mol
AFD 21 Chemical Properties,Uses,Production
Description
AFD-21 is a class I antiarrhythmic agent.
Uses
AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased[1].
References
[1] Electrophysiological effects of AFD-21 and AFD-19, new antiarrhythmic compounds on papillary muscles and single ventricular myocytes isolated from guinea-pig hearts
AFD 21 Preparation Products And Raw materials
Raw materials
Preparation Products
AFD 21 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32436 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29343 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
