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ChemicalBook >> CAS DataBase List >>4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Structure
4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile structure
CAS No.
2308520-97-8
Chemical Name:
4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile
Synonyms
GLPG3667;Tyk2-IN-14;4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile
CBNumber:
CB313625532
Molecular Formula:
C22H21N9O2
Molecular Weight:
443.46
MDL Number:
MOL File:
2308520-97-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 09:01:00
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4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Properties

Boiling point 791.6±70.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 4.72±0.10(Predicted)
form Solid
color Off-white to light yellow

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0905053 Cadefrecitinib 99.81% 2308520-97-8 1mg $195 2026-06-04 Buy
ChemScene CS-0905053 Cadefrecitinib 99.81% 2308520-97-8 5mg $357 2026-06-04 Buy
ChemScene CS-0905053 Cadefrecitinib 99.81% 2308520-97-8 10mg $536 2026-06-04 Buy
ChemScene CS-0905053 Cadefrecitinib 99.81% 2308520-97-8 25mg $975 2026-06-04 Buy
ChemScene CS-0905053 Cadefrecitinib 99.81% 2308520-97-8 50mg $1354 2026-06-04 Buy
Product number Packaging Price Buy
CS-0905053 1mg $195 Buy
CS-0905053 5mg $357 Buy
CS-0905053 10mg $536 Buy
CS-0905053 25mg $975 Buy
CS-0905053 50mg $1354 Buy

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Chemical Properties, Uses, Production

Uses

GLPG3667 is a reversible, ATP-competitive and orally active TYK2 inhibitor with an IC50 of 2.3 nM. GLPG3667 inhibits IFNα/pSTAT1, and the IC50 values in human peripheral blood mononuclear cell (PBMC) and whole blood assays are 70 nM and 623 nM, respectively. GLPG3667 has the potential for the study of inflammatory and autoimmune diseases[1].

in vivo

GLPG3667 (3-30 mg/kg; oral administration, once daily (q.d.); for 5 days) reduces dermal ear inflammation in an IL-23-induced in vivo mouse model of psoriasis[1].

Animal Model:Female BALB/c mice (IL-23-induced psoriasis model)[1]
Dosage:3, 10, and 30 mg/kg (Solutol HS15/methyl cellulose 0.5% (2/98; v/v))
Administration:Oral administration, once daily (q.d.); for 5 days
Result:Successfully reduced ear pinna thickening and STAT3 phosphorylation in the epidermis and dermis. Additionally, reduced neutrophil infiltration in the dermis. However, there was no clear dose-response relationship observed, likely due to other pathways not impacted by TYK2 inhibition.

IC 50

Tyk2: 2.3 nM (IC50); JAK1: 38 nM (IC50); JAK2: 7.3 nM (IC50); JAK3: 374 nM (IC50)

References

[1] Mammoliti O, et al. Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases. J Med Chem. 2024 Jun 13;67(11):8545-8568. DOI:10.1021/acs.jmedchem.4c00769

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. 13771642864 snhuyu_2008@126.com China 1186 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 19370895928 qqyang@aikonchem.com China 9995 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Shanghai Beckham Medical Technology Co., Ltd 55
Dideu Industries Group Limited 58
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Spectrum

4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile(2308520-97-8)1HNMR

2308520-97-8 (4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile) Related Search:

Ruxolitinib NA Phlorizin Anti-Aging Compound Library Protein Tyrosine Kinase Compound Library
Tofacitinib

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4-Methyl-5-[[3-methyl-7-[[6-(4-morpholinyl)-3-pyridazinyl]amino]-3H-imidazo[4,5-b]pyridin-5-yl]oxy]-2-pyridinecarbonitrile Tyk2-IN-14 GLPG3667 2308520-97-8