Ro 5-3335
- CAS No.
- 30195-30-3
- Chemical Name:
- Ro 5-3335
- Synonyms
- Ro 5-3335;NSC-66020;CBFβ-Runx1 inhibitor II;7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one;7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;Ro5-3335,Ro53335,CBFβ,inhibit,binding,Ro-5-3335,core,RUNX1,RUNX1-CBFB,factor,CBF,interaction,leukemia,Inhibitor,Ro5 3335
- CBNumber:
- CB31365501
- Molecular Formula:
- C13H10ClN3O
- Molecular Weight:
- 259.69
- MDL Number:
- MFCD00870704
- MOL File:
- 30195-30-3.mol
- MSDS File:
- SDS
| Melting point | 256 °C(dec.) |
|---|---|
| solubility | Soluble to 100 mM in DMSO |
| form | powder to crystal |
| color | White to Light red to Green |
| FDA UNII | DLH4T68L7I |
| UNSPSC Code | 12352200 |
| NACRES | NA.28 |
Ro 5-3335 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | R0223 | Ro 5-3335 | 30195-30-3 | 10MG | $185 | 2024-03-01 | Buy |
| TCI Chemical | R0223 | Ro 5-3335 | 30195-30-3 | 50MG | $651 | 2024-03-01 | Buy |
| Tocris | 4694 | Ro 5-3335 ≥98%(HPLC) | 30195-30-3 | 10 | $238 | 2021-12-16 | Buy |
| TRC | R700978 | Ro 5-3335 | 30195-30-3 | 10mg | $215 | 2021-12-16 | Buy |
| Usbiological | 256486 | Ro 5-3335 | 30195-30-3 | 10mg | $495 | 2021-12-16 | Buy |
Ro 5-3335 Chemical Properties,Uses,Production
Uses
Ro 5-3335 is a benzodiazepine is a core binding factor (CBF) leukemia inhibitor.
Definition
ChEBI: A 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivati n.
in vivo
Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models[1].
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish[1].
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model[1].
| Animal Model: | C57BL/6 mice (leukemic model)[1] |
| Dosage: | 300 mg/kg |
| Administration: | Oral administration; daily; for 30 days |
| Result: | Reduced the number of c-kit+ cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen. |
storage
Store at +4°C
Ro 5-3335 Preparation Products And Raw materials
Raw materials
Preparation Products
Ro 5-3335 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
