2-Amino-4-hydroxy-1H-pteridine
- CAS No.
- 2236-60-4
- Chemical Name:
- 2-Amino-4-hydroxy-1H-pteridine
- Synonyms
- PTERIN;PTERINE;4-oxopterin;pteridoxamine;Pterine, ≥98%;Pterin【keto form】;2-Amino-4-oxodihyd;2-AMINO-4-PTERIDINOL;2-Aminopteridin-4-ol;Folic Acid Impurity 34
- CBNumber:
- CB3140406
- Molecular Formula:
- C6H5N5O
- Molecular Weight:
- 163.14
- MDL Number:
- MFCD00010557
- MOL File:
- 2236-60-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pterine ~95% | P1132 | 50mg | $105 |
| Pterine ~95% | P1132 | 1g | $502 |
| Pterin ≥95% | 39503 | 50mg | $39 |
| Pterin ≥95% | 39503 | 100mg | $62 |
| Pterin ≥95% | 39503 | 250mg | $97 |
| More product size | |||
| Melting point | 300 °C |
|---|---|
| Boiling point | 290.2°C (rough estimate) |
| Density | 1.4240 (rough estimate) |
| refractive index | 1.9000 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility |
Acetonitrile: Soluble Water: Soluble |
| pka | 2.27(at 20℃) |
| form | powder |
| biological source | synthetic |
| Water Solubility | 17.54mg/L(22.5 ºC) |
| BRN | 150294 |
| InChI | InChI=1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12) |
| InChIKey | HNXQXTQTPAJEJL-UHFFFAOYSA-N |
| SMILES | N1C2C(=NC=CN=2)C(=O)NC=1N |
| CAS DataBase Reference | 2236-60-4(CAS DataBase Reference) |
| FDA UNII | 85MA24E1NH |
| NIST Chemistry Reference | 4(1H)-pteridinone, 2-amino-(2236-60-4) |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UO3505000 | |||||||||
| F | 10-23 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Amino-4-hydroxy-1H-pteridine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P1132 | Pterine ~95% | 2236-60-4 | 50mg | $105 | 2026-04-30 | Buy |
| Sigma-Aldrich | P1132 | Pterine ~95% | 2236-60-4 | 1g | $502 | 2025-07-31 | Buy |
| Cayman Chemical | 39503 | Pterin ≥95% | 2236-60-4 | 50mg | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 39503 | Pterin ≥95% | 2236-60-4 | 100mg | $62 | 2026-04-30 | Buy |
| Cayman Chemical | 39503 | Pterin ≥95% | 2236-60-4 | 250mg | $97 | 2026-04-30 | Buy |
2-Amino-4-hydroxy-1H-pteridine Chemical Properties,Uses,Production
Chemical Properties
YELLOW-BEIGE CRYSTALLINE POWDER
Uses
Pterin is used in the biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
Definition
ChEBI: 2-aminopteridin-4-ol is a 2-amino-4-hydroxypteridine. It is a tautomer of a 2-aminopteridin-4(3H)-one and a 2-aminopteridin-4(1H)-one.
Biological Activity
Pterine consists of pyrazine and pyrimidine with substitutions in keto and amino group. Pterine is present in all organisms including cyanobacteria. It acts as a cofactor for redox enzymes and serves as a precursor for folic acid synthesis. Pterine from the butterfly wings absorb light and elicit incoherent scattering. Pterine induces alterations in DNA by hydroxylation of deoxyguanosine.
Purification Methods
It is dissolved in hot 1% aqueous ammonia, filtered, and an equal volume of hot 1M aqueous formic acid is added. The solution is allowed to cool at 0-2o overnight. The solid is collected and washed with distilled water several times by centrifugation and dried in vacuo over P2O5 overnight, and then at 100o overnight (any ammonium formate in the sample evaporates off). [Beilstein 26 III/IV 3936.]
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] RAMASAMY MAHENDRAN. Evaluation of Pterin, a Promising Drug Candidate from Cyanide Degrading Bacteria.[J]. Current Microbiology, 2018, 75 6: 684-693. DOI: 10.1007/s00284-018-1433-0
[3] SANJEEWA GAMAGEDARA Yinfa M Stephen Gibbons. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer[J]. Clinica Chimica Acta, 2011, 412 1: Pages 120-128. DOI: 10.1016/j.cca.2010.09.015
2-Amino-4-hydroxy-1H-pteridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
