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HIRUDIN (54-65) (DESULFATED)

HIRUDIN (54-65) (DESULFATED) structure

CAS No.: 113274-56-9

Chemical Name:: HIRUDIN (54-65) (DESULFATED)

Synonyms: Hirudin;GDFEEIPEEYLQ;Exhirud，Exhirudine，Hirudex;HIRUDIN (54-65) (DESULFATED);Hirudin(54-65),700-900 ATU/g;HIRUDIN FRAGMENT 54-65 NON-SULFATED;HIRUDIN (54-65) (DESULFATED) USP/EP/BP;113274-56-9---HIRUDIN (54-65) (DESULFATED);GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN;H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH

CBNumber:: CB3140840

Molecular Formula:: C66H93N13O25

Molecular Weight:: 1468.52

MDL Number:: MFCD00076563

MOL File:: 113274-56-9.mol

MSDS File:: SDS

Last updated:2025-07-04 15:04:29

Product description	Number	Pack Size	Price
Hirudin	H4080B	200ug	$462
Hirudin	H4080-01	1mg	$531
Hirudin	H4080-01A	1mg	$531
Hirudin	H4080-01B	1mg	$531
Hirudin	H4080-01C	1mg	$531
More product size

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HIRUDIN (54-65) (DESULFATED) Properties

Boiling point	1913.6±65.0 °C(Predicted)
Density	1.384±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka	3.25±0.10(Predicted)
Sequence	H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH
InChIKey	ZNEKMMIWGPUTGR-YDNADGHJNA-N
LogP	-0.190 (est)
EWG's Food Scores	1
FDA UNII	MNY7X23SRZ

SAFETY

Risk and Safety Statements

WGK Germany	3

HIRUDIN (54-65) (DESULFATED) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	H4080B	Hirudin	113274-56-9	200ug	$462	2021-12-16	Buy
Usbiological	H4080-01	Hirudin	113274-56-9	1mg	$531	2021-12-16	Buy
Usbiological	H4080-01A	Hirudin	113274-56-9	1mg	$531	2021-12-16	Buy
Usbiological	H4080-01B	Hirudin	113274-56-9	1mg	$531	2021-12-16	Buy
Usbiological	H4080-01C	Hirudin	113274-56-9	1mg	$531	2021-12-16	Buy

Product number	Packaging	Price	Buy
H4080B	200ug	$462	Buy
H4080-01	1mg	$531	Buy
H4080-01A	1mg	$531	Buy
H4080-01B	1mg	$531	Buy
H4080-01C	1mg	$531	Buy

HIRUDIN (54-65) (DESULFATED) Chemical Properties,Uses,Production

Chemical Properties

Hirudin is the strongest thrombin retarder so far. It fuses with thrombin to produce a non-covalent nitric oxide synthase with a dissociation constant of the order of 10-12 and a very fast reaction rate. quick. Hirudin and thrombin have strong infectivity, 1μg can neutralize 5μg thrombin, and the molar ratio is 1:1.

Uses

Hirudin is a small protein (polypeptide) composed of 65-66 amino acids. Hirudin has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin found so far.

Description

Recombinant Hirudin is derived from yeast and the polypeptide chain contains 65 amino acids and its Mw is 6979.5 Dalton which is identical to natural Hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
The Recombinant Hirudin is purified by proprietary chromatographic techniques.

Source

Pichia Pastoris

Background

Recombinant Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech. Hirudin acts directly on thrombin rather than through other clotting factors. The mechanism of Hirudin-thrombin appears to be unique. The conversion of fibrinogen into fibrin by the serine protease enzyme thrombin is a major event in the final stages of blood coagulation. In the final stages of coagulation prothrombinase converts prothrombin into thrombin. Fibrin is subsequently cross linked by factor XIII to form a blood clot. The primary inhibitor of thrombin in normal blood circulation is antithrombin III. The anticoagulatant activity of hirudin is derived from its ability to inhibit the pro-coagulant activity of thrombin (similar to antithrombin III activity). Hirudin is the strongest natural inhibitor of thrombin. Hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen contrasting to antithrombin III activity. Therefore, hirudin has a thrombolytic activity since it prevents or dissolves the formation of clots and thrombi. Hirudin also has therapeutic significance in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins. Hirudin does not hinder with the biological activity of other serum proteins and can also act on complexed thrombin, thus having an advantage over more common anticoagulants and thrombolytics. It is complicated to extract large quantities of hirudin from natural sources; therefore a method for producing and purifying hirudin using recombinant biotechnology has been developed.

HIRUDIN (54-65) (DESULFATED) Preparation Products And Raw materials

Raw materials

Preparation Products

HIRUDIN (54-65) (DESULFATED) Suppliers

Global( 212)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	1169	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	1287	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11727	58
Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58

Supplier	Advantage
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Xi'an Kono chem co., Ltd.,	58
Shaanxi Pioneer Biotech Co., Ltd .	58
BOC Sciences	58
Cellmano Biotech Limited	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Creative Enzymes	58

View Lastest Price from HIRUDIN (54-65) (DESULFATED) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-09	HIRUDIN (54-65) (DESULFATED) 113274-56-9	US $0.00-0.00 / kg	1kg	98% HPLC	1000kg	Changsha Staherb Natural Ingredients Co., Ltd.
2025-04-15	HIRUDIN (54-65) (DESULFATED) 113274-56-9	US $60.00 / kg	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-03-16	HIRUDIN (54-65) (DESULFATED) 113274-56-9	US $35.00-25.00 / kg	1kg	99.8%	200tons/year	Sigma Audley

HIRUDIN (54-65) (DESULFATED)
113274-56-9
US $0.00-0.00 / kg
98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

HIRUDIN (54-65) (DESULFATED)
113274-56-9
US $60.00 / kg
99
Hebei Zhuanglai Chemical Trading Co.,Ltd

HIRUDIN (54-65) (DESULFATED)
113274-56-9
US $35.00-25.00 / kg
99.8%
Sigma Audley

113274-56-9(HIRUDIN (54-65) (DESULFATED))Related Search:

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HIRUDIN (54-65) (DESULFATED) HIRUDIN FRAGMENT 54-65 NON-SULFATED H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN Hirudin GDFEEIPEEYLQ L-Glutamine, glycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucyl- HIRUDIN (54-65) (DESULFATED) USP/EP/BP 113274-56-9---HIRUDIN (54-65) (DESULFATED) Exhirud，Exhirudine，Hirudex L-Glutamine, glycyl-L-a-aspartyl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-isoleucyl-L-prolyl-L-a-glutamyl-L-a-glutamyl-L-tyrosyl-L-leucyl-(9CI) Hirudin(54-65),700-900 ATU/g 113274-56-9 C66H93N13O25 Miscellaneous Peptides Peptides Hirudin Fragments BioChemical Amino Acids and Peptides Biochemicals and Reagents API Hirudin Fragments Miscellaneous Peptides Peptides for Cell Biology