Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-.
- CAS No.
- 110543-98-1
- Chemical Name:
- Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-.
- Synonyms
- Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate;Arbidol Impurity 40;Arbidol Impurity 62;Abidore Impurity 31;Umifenovir impurity 9;Abbidore intermediate 4;5-Acetoxy-6-bromo-2-(bromomethyL;Ethyl 5-acetoxy-6-broMo-2-broMoMethyl-1-Methylindo;Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-.;ETHYL 5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METH 110543-98-1
- CBNumber:
- CB31430768
- Molecular Formula:
- C15H15Br2NO4
- Molecular Weight:
- 433.09
- MDL Number:
- MFCD00407019
- MOL File:
- 110543-98-1.mol
- MSDS File:
- SDS
| Melting point | 168-171 °C(Solv: carbon tetrachloride (56-23-5)) |
|---|---|
| Boiling point | 529.8±50.0 °C(Predicted) |
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | Brown to gray Solid |
| InChI | InChI=1S/C15H15Br2NO4/c1-4-21-15(20)14-9-5-13(22-8(2)19)10(17)6-11(9)18(3)12(14)7-16/h5-6H,4,7H2,1-3H3 |
| InChIKey | MESMQGKAVXOGHJ-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=C(OC(C)=O)C(Br)=C2)C(C(OCC)=O)=C1CBr |
| CAS DataBase Reference | 110543-98-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2933998090 |
| REACH Registrations | Active |
Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-. price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FE150314 | Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate | 110543-98-1 | 100mg | $250 | 2026-06-04 | Buy |
| Biosynth | FE150314 | Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate | 110543-98-1 | 50mg | $250 | 2026-06-04 | Buy |
| Biosynth | FE150314 | Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate | 110543-98-1 | 250mg | $330 | 2026-06-04 | Buy |
| Biosynth | FE150314 | Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate | 110543-98-1 | 500mg | $580 | 2026-06-04 | Buy |
| Biosynth | FE150314 | Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate | 110543-98-1 | 1000mg | $1000 | 2026-06-04 | Buy |
Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-. Chemical Properties, Uses, Production
Uses
Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate can be used as an intermediate for Arbidol.
Synthesis
40945-79-7
110543-98-1
General procedure for the synthesis of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate from ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate: 137.6 g (0.45 mol) of ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate was dissolved in 1000 mL of chloroform with stirring until completely dissolved. A catalytic amount of benzoyl peroxide was added and heated to reflux. 64.0 mL (200 g, 1.25 mol) of liquid bromine was added slowly dropwise and the reaction was continued at reflux for 3 hours after completion of the dropwise addition. Upon completion of the reaction, the reaction mixture was cooled to room temperature and a solid was precipitated. The solid was washed with a small amount of methanol and dried to give 184.0 g of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate in 85.0% yield.
References
[1] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 1, p. 75 - 76
[2] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 1, p. 70 - 71
[3] Patent: CN106083691, 2016, A. Location in patent: Paragraph 0025; 0055; 0056
[4] Patent: US5198552, 1993, A
[5] Patent: EP1731506, 2006, A1. Location in patent: Page/Page column 12; 16
Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-. Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Jiecheng Pharmaceutical Co., Ltd | 0531-83130525 18560095177 | lily.chen@jiechengpharm.com | China | 25 | 58 |
| Jinan Shengqi Pharmaceutical Co., Ltd | 0531-82687819 15610111696 | xgc01@orgachem.com | China | 178 | 58 |
| Beijing Mediking Biopharm Co., Ltd | 010-81769521,89753524,81760121 15901403431 | sales01@mediking.cn | China | 100 | 68 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
View Latest Price from Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-. manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-11-26 | Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate
110543-98-1
|
1kg | 98%HPLC | 20 tons | Nanjing Fred Technology Co., Ltd | ||
 |
2019-09-02 | ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
110543-98-1
|
$7.00 | 1KG | 99% | Career Henan Chemical Co | ||
|
|
2019-09-02 | ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
110543-98-1
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate
110543-98-1
- 98%HPLC
- Nanjing Fred Technology Co., Ltd
-
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
110543-98-1
- $7.00
- 99%
- Career Henan Chemical Co
-
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
110543-98-1
- $7.00
- 99%
- Career Henan Chemical Co
