5-Bromo-3-cyano-2-methoxypyridine
- CAS No.
- 941294-54-8
- Chemical Name:
- 5-Bromo-3-cyano-2-methoxypyridine
- Synonyms
- 5-Bromo-2-methoxynicotinonitrile;5-Bromo-3-cyano-2-methoxypyridine;3-Bromo-5-cyano-6-methoxypyridine;5-Bromo-2-methoxynicotinonitrile98%;5-bromo-2-methoxypyridine-3-carbonitrile;5-Bromo-2-methoxy-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-bromo-2-methoxy-;5-Bromo-2-methoxypyridine-3-carbonitrile, 5-Bromo-3-cyano-2-methoxypyridine
- CBNumber:
- CB31457516
- Molecular Formula:
- C7H5BrN2O
- Molecular Weight:
- 213.03
- MDL Number:
- MFCD09801047
- MOL File:
- 941294-54-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-methoxypyridine-3-carbonitrile 97% | 739146 | 1g | $81.4 |
| 5-Bromo-2-methoxynicotinonitrile 95+% | B12773 | 250mg | $23 |
| 5-Bromo-2-methoxynicotinonitrile 95+% | B12773 | 1g | $29 |
| 5-Bromo-2-methoxynicotinonitrile 95+% | B12773 | 5g | $90 |
| 5-Bromo-2-methoxynicotinonitrile 95+% | B12773 | 10g | $150 |
| More product size | |||
| Melting point | 110-115°C |
|---|---|
| Boiling point | 267℃ |
| Density | 1.65 |
| Flash point | 115℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | -2.40±0.20(Predicted) |
| color | white |
| InChI | 1S/C7H5BrN2O/c1-11-7-5(3-9)2-6(8)4-10-7/h2,4H,1H3 |
| InChIKey | FRKLCMNRGGZZTQ-UHFFFAOYSA-N |
| SMILES | COc1ncc(Br)cc1C#N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H318-H335 |
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 |
| target organs | Respiratory system |
| Hazard Codes | Xi,T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-36-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933399990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
5-Bromo-3-cyano-2-methoxypyridine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 739146 | 5-Bromo-2-methoxypyridine-3-carbonitrile 97% | 941294-54-8 | 1g | $81.4 | 2023-06-20 | Buy |
| Synthonix | B12773 | 5-Bromo-2-methoxynicotinonitrile 95+% | 941294-54-8 | 250mg | $23 | 2026-05-06 | Buy |
| Synthonix | B12773 | 5-Bromo-2-methoxynicotinonitrile 95+% | 941294-54-8 | 1g | $29 | 2026-05-06 | Buy |
| Synthonix | B12773 | 5-Bromo-2-methoxynicotinonitrile 95+% | 941294-54-8 | 5g | $90 | 2026-05-06 | Buy |
| Synthonix | B12773 | 5-Bromo-2-methoxynicotinonitrile 95+% | 941294-54-8 | 10g | $150 | 2026-05-06 | Buy |
5-Bromo-3-cyano-2-methoxypyridine Chemical Properties,Uses,Production
Uses
5-Bromo-2-methoxynicotinonitrile can be used as a pharmaceutical synthesis intermediate.
Synthesis
7254-34-4
941294-54-8
General procedure for the synthesis of 5-bromo-3-cyano-2-methoxypyridine from 3-cyano-2-methoxypyridine: 12.23 g (149 mmol) of sodium acetate and 7.66 mL (149 mmol) of bromine were added drop-wise to 29 mL of acetic acid solution containing 10 g (74.6 mmol) of 3-cyano-2-methoxypyridine at 0 °C. The reaction mixture was then heated at 70 °C for overnight reaction. Upon completion of the reaction, the reaction system was cooled to room temperature and poured into an ice bath. The precipitated solid product was collected by filtration, washed thoroughly with water and dried at 50 °C to afford 11.6 g (73% yield) of the target compound 5-bromo-3-cyano-2-methoxypyridine as a white solid. The product was analyzed by LC-MS (EI, m/z) to confirm: (M+1) 214.95. 1H NMR (400 MHz, DMSO-d6) δ: 8.61 (1H, d, J = 2.4 Hz, Ar-H), 8.60 (1H, d, J = 2.4 Hz, Ar-H), 3.98 (3H, s, OCH3).
References
[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0281; 0282; 0283
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0185
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 54
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 53-54
5-Bromo-3-cyano-2-methoxypyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Cochemical Co. Ltd. | +86-029-86115547 +86-17791676824 | sales@cochemical.com | China | 3952 | 58 |
| ANHUI BYERSEN BIOTECH CO. LTD | +86-15385096007 +86-17755058861 | amy@byersenchemical.com | China | 10000 | 58 |
View Lastest Price from 5-Bromo-3-cyano-2-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | 5-Bromo-3-cyano-2-methoxypyridine
941294-54-8
|
$1.00 | 1g | 99% | Career Henan Chemical Co |
-
- 5-Bromo-3-cyano-2-methoxypyridine
941294-54-8
- $1.00
- 99%
- Career Henan Chemical Co
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