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ChemicalBook >> CAS DataBase List >>5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Structure
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide structure
CAS No.
944261-79-4
Chemical Name:
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide
Synonyms
brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;A-803467, 10 mM in DMSO;A 803467, NaV1.8 channel blocker
CBNumber:
CB31471262
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.79
MDL Number:
MFCD10574689
MOL File:
944261-79-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:57:57
Product description Number Pack Size Price
A-803467 ≥98% (HPLC) A3109 10mg $192
A-803467 ≥98% (HPLC) A3109 50mg $771
A-803467 ≥98% 10012588 5mg $41
A-803467 ≥98% 10012588 10mg $75
A-803467 ≥98% 10012588 50mg $312
More product size
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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Properties

Melting point 128-130C
Boiling point 450.6±45.0 °C(Predicted)
Density 1.294±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >10mg/mL
pka 11.72±0.70(Predicted)
form powder
color white to tan
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChIKey VHKBTPQDHDSBSP-UHFFFAOYSA-N
SMILES COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
FDA UNII 339LBH1395
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A3109 A-803467 ≥98% (HPLC) 944261-79-4 10mg $192 2026-04-30 Buy
Sigma-Aldrich A3109 A-803467 ≥98% (HPLC) 944261-79-4 50mg $771 2026-04-30 Buy
Cayman Chemical 10012588 A-803467 ≥98% 944261-79-4 5mg $41 2026-04-30 Buy
Cayman Chemical 10012588 A-803467 ≥98% 944261-79-4 10mg $75 2026-04-30 Buy
Cayman Chemical 10012588 A-803467 ≥98% 944261-79-4 50mg $312 2026-04-30 Buy
Product number Packaging Price Buy
A3109 10mg $192 Buy
A3109 50mg $771 Buy
10012588 5mg $41 Buy
10012588 10mg $75 Buy
10012588 50mg $312 Buy

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Chemical Properties,Uses,Production

Description

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemical Properties

White Solid

Uses

A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain. Analgesic.

General Description

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biological Activity

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Biochem/physiol Actions

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

storage

+4°C

References

[1] MICHAEL F JARVIS. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007: 8520-8525. DOI:10.1073/pnas.0611364104
[2] STEVE MCGARAUGHTY. A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 324 3: 1204-1211. DOI:10.1124/jpet.107.134148

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Suppliers

Global( 152)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9544 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28509 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11680 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
A-803467 pictures 2026-05-11 A-803467
944261-79-4
 $29.00-113.00 98.00% 10g TargetMol Chemicals Inc.
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide pictures 2019-09-06 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide
944261-79-4
 $1.00 1KG 95%~99% Career Henan Chemical Co
  • A-803467 pictures
  • A-803467
    944261-79-4
  • $29.00-113.00
  • 98.00%
  • TargetMol Chemicals Inc.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Spectrum

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide(944261-79-4)1HNMR

944261-79-4(5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide)Related Search:

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BATRACHOTOXIN A-803467 CHEMBRDG-BB 5929971

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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide A 803467 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)- 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 A-803467, >=99% A803467;A 803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt brgt -dimethoxyphenylamide A-803467, >98% CS-374 [3H]-A-803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP A 803467, NaV1.8 channel blocker A-803467, 10 mM in DMSO Human Umbilical Cord Mesenchymal Stem CellsCP-CL11 944261-79-4 Ion Channels Inhibitors Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sodium channel