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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

CAS No.
208517-35-5
Chemical Name:
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
Synonyms
Ethyl 2-(trifluoromethyl)nicotinate;2-Trifluoromethyl-nicotinic acid ethyl ester;ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001:2015 REACH
CBNumber:
CB31500218
Molecular Formula:
C9H8F3NO2
Molecular Weight:
219.16
MDL Number:
MFCD08741365
MOL File:
208517-35-5.mol
MSDS File:
SDS
Last updated:2026-05-28 00:58:23
Product description Number Pack Size Price
Ethyl 2-(trifluoromethyl)nicotinate 95% PC9260 1g $234
Ethyl 2-(trifluoromethyl)nicotinate 95% PC9260 5g $966
Ethyl 2-(trifluoromethyl)nicotinate 95% PC9260 1g $234
Ethyl 2-(trifluoromethyl)nicotinate 95% PC9260 5g $966
Ethyl 2-(trifluoromethyl)nicotinate 083416 250.00mg $57
More product size

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Properties

Boiling point 235.8±40.0 °C(Predicted)
Density 1.284±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.38±0.22(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC9260 Ethyl 2-(trifluoromethyl)nicotinate 95% 208517-35-5 1g $234 2026-06-04 Buy
Apolloscientific PC9260 Ethyl 2-(trifluoromethyl)nicotinate 95% 208517-35-5 5g $966 2026-06-04 Buy
Apolloscientific PC9260 Ethyl 2-(trifluoromethyl)nicotinate 95% 208517-35-5 1g $234 2026-06-04 Buy
Apolloscientific PC9260 Ethyl 2-(trifluoromethyl)nicotinate 95% 208517-35-5 5g $966 2026-06-04 Buy
Matrix Scientific 083416 Ethyl 2-(trifluoromethyl)nicotinate 208517-35-5 250.00mg $57 2026-05-18 Buy
Product number Packaging Price Buy
PC9260 1g $234 Buy
PC9260 5g $966 Buy
PC9260 1g $234 Buy
PC9260 5g $966 Buy
083416 250.00mg $57 Buy

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production

Chemical Properties

Yellow liquid

Synthesis

2,4-Pentadienoic acid, 5-(diMethylaMino)-2-(2,2,2-trifluoroacetyl)-, ethyl ester

1146961-22-9

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

208517-35-5

In a 1 L single neck round bottom flask equipped with a magnetic stirrer and a reflux condenser, ethyl (2E,4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienoate (80.50 g, 303.8 mmol) was dissolved in a solvent mixture of methanol (700 mL) and 25% aqueous ammonia solution (240 mL). The reaction mixture was heated to 70 °C and maintained for 20 minutes. It was then cooled to room temperature and the methanol was removed by distillation under reduced pressure. The residue was diluted with water (200 mL) and extracted with ether (2 x 300 mL). The organic phases were combined, washed with saturated brine (200 mL), dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure to give 65.0 g of red oily crude product. The crude product was pure enough for subsequent reactions. For further purification, the crude product was filtered through a short silica gel column, followed by evaporation of the filtrate to give 59.9 g of light yellow flowing oil in 90% yield.

References

[1] Patent: WO2009/54742, 2009, A2. Location in patent: Page/Page column 13-14

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Global( 122)Suppliers
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Capot Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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View Lastest Price from 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER  pictures 2025-11-18 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
208517-35-5
$1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Ethyl 2-(trifluoromethyl)nicotinate pictures 2020-01-10 Ethyl 2-(trifluoromethyl)nicotinate
208517-35-5
$9.80 1KG ≥98% 20 tons Career Henan Chemical Co

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Spectrum

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 2-Trifluoromethyl-nicotinic acid ethyl ester Ethyl 2-(trifluoromethyl)nicotinate ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001:2015 REACH 208517-35-5 Building Blocks Pyridine