4-bromobutyl nitrate
- CAS No.
- 146563-40-8
- Chemical Name:
- 4-bromobutyl nitrate
- Synonyms
- SKL119;4-bromobutyl nitrate;4-(nitrooxy)butyl bromide;4-Bromo-1-butanol 1-Nitrate;1-Butanol, 4-bromo-, 1-nitrate
- CBNumber:
- CB31502702
- Molecular Formula:
- C4H8BrNO3
- Molecular Weight:
- 198.02
- MDL Number:
- MFCD27944939
- MOL File:
- 146563-40-8.mol
- MSDS File:
- SDS
| Boiling point | 220.0±23.0 °C(Predicted) |
|---|---|
| Density | 1.560±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Pale Yellow |
| InChI | InChI=1S/C4H8BrNO3/c5-3-1-2-4-9-6(7)8/h1-4H2 |
| InChIKey | IKDHVMDABUMCLO-UHFFFAOYSA-N |
| SMILES | C(O[N+]([O-])=O)CCCBr |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
4-bromobutyl nitrate Chemical Properties,Uses,Production
Uses
4-bromobutyl nitrate is an intermediate in synthesizing Latanoprostene Bunod (L177335). It is a derivative of Latanoprost and is used in the treatment of interocular pressure.
Preparation
4-Bromobutyl nitrate is a thermally unstable oily liquid, which is used to obtain nitrooxyalkyl esters of pharmacologically active carboxylic acids (WO 04/020384, WO 04/020385). 4-Bromobutyl nitrate not dissolved in solvents is added to the solution / suspension of pharmacologically active carboxylic acids such as naproxen, ferulic acid, etc. 4-Bromobutyl nitrate is obtained by nitration with a sulfonitizing mixture of 4-bromo-1-hydroxybutane (Chem. Pharm. Bull., 1993, 41, p. 1040). The reaction is carried out by adding 4-bromo-1-hydroxybutane to the crude sulphonating mixture in the absence of solvents or diluents. The reaction is limited to a laboratory scale since the method is potentially explosive due to a sudden increase in temperature and gas production.
https://patents.google.com/patent/RU2388746C2/en
4-bromobutyl nitrate Preparation Products And Raw materials
4-bromobutyl nitrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9899 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54999 | 58 |
| Ningbo jinuo chemical co., LTD | 0574-87314919 057487319282 | info@nbinno.com | China | 7047 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8045 | 58 |
View Lastest Price from 4-bromobutyl nitrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-07-22 | 4-bromobutyl nitrate
146563-40-8
|
US $0.00-0.00 / kg | 1kg | 98% | kgs | Coresyn Pharmatech Co., Ltd. |
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- 4-bromobutyl nitrate
146563-40-8
- US $0.00-0.00 / kg
- 98%
- Coresyn Pharmatech Co., Ltd.
