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ChemicalBook >> CAS DataBase List >>3,8-Diaza-bicyclo[3.2.1]octane

3,8-Diaza-bicyclo[3.2.1]octane

3,8-Diaza-bicyclo[3.2.1]octane Structure
3,8-Diaza-bicyclo[3.2.1]octane structure
CAS No.
280-06-8
Chemical Name:
3,8-Diaza-bicyclo[3.2.1]octane
Synonyms
EOS-62178;3,8-Diaza-bicyclo[3.2.1]octane;3,8-Diazabicyclo[3.2.1]octane, 95+%
CBNumber:
CB31508481
Molecular Formula:
C6H12N2
Molecular Weight:
112.17
MDL Number:
MFCD23131267
MOL File:
280-06-8.mol
Last updated:2025-12-10 10:59:02
Product description Number Pack Size Price
3,8-DIAZABICYCLO-[3.2.1]-OCTANE 95.00% CHM0385949 5MG $497.57
3,8-Diaza-bicyclo[3.2.1]octane 96% 75R0460 5g $998
3,8-Diazabicyclo[3.2.1]octane 97.00% E0020 1G $3120
3,8-Diazabicyclo[3.2.1]octane 97.00% E0020 5G $5360
3,8-Diaza-bicyclo[3.2.1]octane 96% 75R0460 50mg $98
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3,8-Diaza-bicyclo[3.2.1]octane Properties

Boiling point 78-80 °C(Press: 40 Torr)
Density 0.975±0.06 g/cm3(Predicted)
pka 10.32±0.20(Predicted)

3,8-Diaza-bicyclo[3.2.1]octane price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation CHM0385949 3,8-DIAZABICYCLO-[3.2.1]-OCTANE 95.00% 280-06-8 5MG $497.57 2021-12-16 Buy
J&W Pharmlab 75R0460 3,8-Diaza-bicyclo[3.2.1]octane 96% 280-06-8 5g $998 2021-12-16 Buy
AccelPharmtech E0020 3,8-Diazabicyclo[3.2.1]octane 97.00% 280-06-8 1G $3120 2021-12-16 Buy
AccelPharmtech E0020 3,8-Diazabicyclo[3.2.1]octane 97.00% 280-06-8 5G $5360 2021-12-16 Buy
J&W Pharmlab 75R0460 3,8-Diaza-bicyclo[3.2.1]octane 96% 280-06-8 50mg $98 2021-12-16 Buy
Product number Packaging Price Buy
CHM0385949 5MG $497.57 Buy
75R0460 5g $998 Buy
E0020 1G $3120 Buy
E0020 5G $5360 Buy
75R0460 50mg $98 Buy

3,8-Diaza-bicyclo[3.2.1]octane Chemical Properties,Uses,Production

Chemical Properties

A colorless fluid boiling 178-180° with piperazine-like smell, which quickly adsorbs carbon dioxide when exposed to air.[2]

Uses

The ring-system of 3,8-Diaza-bicyclo[3.2.1]octane is at once related to piperazine and to nortropine, both progenitors of many compounds of physiological importance, synthesis of 3,8-Diaza-bicyclo[3.2.1]octane seemed likely to be rewarding.[1]

Synthesis

From 3-bentyl-3,8-diazabicyclooctane[3.2.1] (V). A solution of 20 g of 3-benzyl-3,8-diazabicyclooctane [3.2.1] in 400 ml of absolute ethanol was hydrogenated in the presence of 10 g. of 10% palladium on charcoal in an autoclave at 60° and 40 atm. pressure. After 3 hr., heating was stopped and the solution allowed to cool to room temperature. Then the catalyst was filtered off, the alcohol removed at atmospheric pressure, and the concentrated solution was distilled; yield 8.8 g. of 3,8-Diaza-bicyclo[3.2.1]octane (80%) ; b.p. 176-178'. The product easily adsorbed carbon dioxide when exposed to air. A sample was distilled again and the fraction boiling at 78-80°/40 mm. was collected and immediately analyzed.[2]
3,8-Diaza-bicyclo[3.2.1]octane synthesis

References

[1] SAMUEL W. BLACKMAN   RICHARD B. The Synthesis of 3,8-Diazabicyclo[3.2.1]octane and Some of Its N-Substituted Derivatives[J]. The Journal of Organic Chemistry, 1961, 26 8: 2750-2755. DOI:10.1021/jo01066a032.
[2] GIORGIO CIGNARELLA   EMILIO O  GIANGIACOMO NATHANSOHN. Bicyclic Homologs of Piperazine. II. Synthesis of 3,8-Diazabicyclo[3.2.1]octane. New Synthesis of 8-Methyl-3,8-diazabicyclo[3.2.1]octane[J]. The Journal of Organic Chemistry, 1961, 26 8: 2747-2750. DOI:10.1021/jo01066a031.

3,8-Diaza-bicyclo[3.2.1]octane Preparation Products And Raw materials

Raw materials

Preparation Products

3,8-Diaza-bicyclo[3.2.1]octane Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
VladaChem GmbH 		+49-7246-3082843 info@vladachem.de Germany 1859 58
SynAsst Chemical. 021-60343070 China 12740 55
Jinan elephant international trading co., LTD 13006575422@163.com China 6355 58
Aikon International Limited 025-58851090 15955137747 sales01@aikonchem.com China 15949 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 022-23989838 13810451150 44766350@qq.com China 2448 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 54995 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 13761987713 hxzheng@sunwaypharm.cn China 9908 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Alchem Pharmtech,Inc. 		58
VladaChem GmbH 		58
SynAsst Chemical. 55
Jinan elephant international trading co., LTD 58
Aikon International Limited 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58

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3,8-Diaza-bicyclo[3.2.1]octane EOS-62178 3,8-Diazabicyclo[3.2.1]octane, 95+% 280-06-8