2-FLUORO-5-HYDROXYBENZOIC ACID
- CAS No.
- 51446-30-1
- Chemical Name:
- 2-FLUORO-5-HYDROXYBENZOIC ACID
- Synonyms
- 3-Carboxy-4-fluorophenol;2-Fluoro-5-hydroxybenzoicaci;2-Fluro-5-Hydroxybenzoic Acid;2-fluoro-5-hydroxybenozicacid;2-FLUORO-5-HYDROXYBENZOIC ACID;Benzoic acid, 2-fluoro-5-hydroxy-
- CBNumber:
- CB3151077
- Molecular Formula:
- C7H5FO3
- Molecular Weight:
- 156.11
- MDL Number:
- MFCD01862084
- MOL File:
- 51446-30-1.mol
- MSDS File:
- SDS
| Melting point | 201-203°C |
|---|---|
| Boiling point | 354.8±27.0 °C(Predicted) |
| Density | 1.492±0.06 g/cm3(Predicted) |
| storage temp. | RT, stored under nitrogen |
| pka | 3.15±0.10(Predicted) |
| form | Powder |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 51446-30-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | C,Xi,Xn | |||||||||
| Risk Statements | 36/37/38-51-41-22 | |||||||||
| Safety Statements | 26-36-39 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2918290090 | |||||||||
| NFPA 704 |
|
2-FLUORO-5-HYDROXYBENZOIC ACID price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F596048 | 2-Fluoro-5-hydroxybenzoicacid | 51446-30-1 | 1g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 009240 | 2-Fluoro-5-hydroxybenzoic acid | 51446-30-1 | 5g | $77 | 2021-12-16 | Buy |
| AK Scientific | X2155 | 2-Fluoro-5-hydroxybenzoicacid | 51446-30-1 | 1g | $71 | 2021-12-16 | Buy |
| Apolloscientific | PC9534 | 2-Fluoro-5-hydroxybenzoicacid | 51446-30-1 | 1g | $18 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2629-3-10 | 2-Fluoro-5-hydroxybenzoic acid | 51446-30-1 | 1g | $20 | 2021-12-16 | Buy |
2-FLUORO-5-HYDROXYBENZOIC ACID Chemical Properties,Uses,Production
Chemical Properties
off-white crytalline
Synthesis
1084801-91-1
51446-30-1
Step 1: Methyl 2-fluoro-5-hydroxybenzoate (30.0 g, 176.47 mmol, 1.0 eq.) was dissolved in a solvent mixture of THF and H2O (3:1 v/v, total 350 mL). To this solution was added LiOH-H2O (22.2 g, 529.41 mmol, 3.0 eq.) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, THF was removed by distillation under reduced pressure and the residue was diluted with cold water. The pH was adjusted to about 3 with 1.5 N HCl aqueous solution and the aqueous phase was extracted with EtOAc (3 x 250 mL). The organic phases were combined, washed with brine (150 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 2-fluoro-5-hydroxybenzoic acid as an off-white solid (25.1 g, 91% yield).MS m/z: [M-1]? = 155.4.
References
[1] Patent: WO2015/51043, 2015, A1. Location in patent: Paragraph 00248
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7818 - 7839
2-FLUORO-5-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12248 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 2-FLUORO-5-HYDROXYBENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-07-13 | 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-FLUORO-5-HYDROXYBENZOIC ACID
51446-30-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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