2-cyano-2-methylpropanoic acid
- CAS No.
- 22426-30-8
- Chemical Name:
- 2-cyano-2-methylpropanoic acid
- Synonyms
- 2-Cyanoisobutyric acid;2-Cyano-2-methylpropanoicaci;2-Cyano-2-methylpropionic acid;2-cyano-2-methylpropanoic acid;2-cyano-2,2-dimethylacetic acid;Propanoic acid, 2-cyano-2-methyl-;2-Cyano-2,2-dimethylaceticacid,95%
- CBNumber:
- CB31540982
- Molecular Formula:
- C5H7NO2
- Molecular Weight:
- 113.11
- MDL Number:
- MFCD11100210
- MOL File:
- 22426-30-8.mol
- MSDS File:
- SDS
| Melting point | 153-155° |
|---|---|
| Boiling point | 132-135℃/12mm |
| Density | 1.141±0.06 g/cm3(Predicted) |
| storage temp. | Store at room temperature |
| form | Crystalline Solid |
| pka | pKa: 2.422(25°C) |
| color | White |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C5H7NO2/c1-5(2,3-6)4(7)8/h1-2H3,(H,7,8) |
| InChIKey | DZDVNAVPCCNJRK-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(C#N)(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H314-H318-H332 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
2-cyano-2-methylpropanoic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XAA42630 | 2-Cyano-2,2-dimethylacetic acid | 22426-30-8 | 5g | $295 | 2026-06-05 | Buy |
| Biosynth | XAA42630 | 2-Cyano-2,2-dimethylacetic acid | 22426-30-8 | 50g | $1770 | 2026-06-05 | Buy |
| Matrix Scientific | 046787 | 2-Cyano-2-methylpropanoic acid | 22426-30-8 | 1.00g | $28 | 2026-05-18 | Buy |
| Matrix Scientific | 046787 | 2-Cyano-2-methylpropanoic acid | 22426-30-8 | 5.00g | $102 | 2026-05-18 | Buy |
| Matrix Scientific | 046787 | 2-Cyano-2-methylpropanoic acid | 22426-30-8 | 25.00g | $300 | 2026-05-18 | Buy |
2-cyano-2-methylpropanoic acid Chemical Properties, Uses, Production
Synthesis
1572-98-1
22426-30-8
Preparation of Example A4-3: 2-cyano-2-methylpropionyl chloride; To a solution of commercially available ethyl 2-cyano-2-methylpropionate (3.5 g, 24.8 mmol) in methanol (10 ml) was added lithium hydroxide (LiOH, 900 mg, 37.2 mmol) and water (0.5 ml) and the reaction was stirred for 1 hour at 37°C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent, followed by acidification by addition of 1N hydrochloric acid (HCl, 50 ml) and extraction with ethyl acetate (EtOAc). The combined organic layers were dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 2-cyano-2-methylpropionic acid (2.67 g, 95% yield). The compound (2.5 g, 22 mmol) was dissolved in dichloromethane (DCM, 7 ml) and the reaction was carried out as described in Step B of Preparation Example A4-1, resulting in the target product 2-cyano-2-methylpropionyl chloride (2.5 g, 86.3% yield).
References
[1] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 30-31
[2] Synthesis, 2005, # 4, p. 569 - 574
[3] Patent: US2018/282328, 2018, A1. Location in patent: Paragraph 0832; 0833
[4] Chemische Berichte, 1932, vol. 65, p. 432,441
[5] Journal of the American Chemical Society, 1916, vol. 38, p. 911
2-cyano-2-methylpropanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-cyano-2-methylpropanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3982 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 2-cyano-2-methylpropanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-15 | 2-Cyano-2-methylpropanoic Acid
22426-30-8
|
$1.00 | 1kg | 98% | 10 tons | Wuhan Konberd Biotech Co., Ltd | |
 |
2020-01-10 | 2-cyano-2-methylpropanoic acid
22426-30-8
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 2-Cyano-2-methylpropanoic Acid
22426-30-8
- $1.00
- 98%
- Wuhan Konberd Biotech Co., Ltd
-
- 2-cyano-2-methylpropanoic acid
22426-30-8
- $1.00
- 99.0%
- Career Henan Chemical Co
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