Diethyl ethoxymethylenemalonate
- CAS No.
- 87-13-8
- Chemical Name:
- Diethyl ethoxymethylenemalonate
- Synonyms
- EMME;Diethyl 2-(ethoxymethylene)malonate;DEEMM;Diethyl 2-(ethoxymethylene)propanedioate;ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER;onate;2-Ethoxymethylene-malonic acid diethyl ester;tl1483;enemaL;NSC 9068
- CBNumber:
- CB3163908
- Molecular Formula:
- C10H16O5
- Molecular Weight:
- 216.23
- MDL Number:
- MFCD00009148
- MOL File:
- 87-13-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Nalidixic acid impurity C EuropePharmacopoeia (EP) Reference Standard | Y0001792 | Y0001792 | $204 |
| Diethyl ethoxymethylenemalonate for LC-MS derivatization, ≥98.0% (GC) | 05689 | 1ml | $31 |
| Diethyl Ethoxymethylenemalonate >98.0%(GC) | E0255 | 25mL | $21 |
| Diethyl Ethoxymethylenemalonate >98.0%(GC) | E0255 | 100mL | $27 |
| Diethyl ethoxymethylenemalonate 99% | D94208 | 100g | $53.7 |
| More product size | |||
| Melting point | -33°C |
|---|---|
| Boiling point | 279-283 °C(lit.) |
| Density | 1.080 g/mL at 20 °C(lit.) |
| vapor pressure | <0.1 hPa |
| refractive index |
n |
| Flash point | 311 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Water Solubility | insoluble |
| BRN | 880058 |
| InChI | 1S/C10H16O5/c1-4-13-7-8(9(11)14-5-2)10(12)15-6-3/h7H,4-6H2,1-3H3 |
| InChIKey | LTMHNWPUDSTBKD-UHFFFAOYSA-N |
| SMILES | CCO\C=C(\C(=O)OCC)C(=O)OCC |
| LogP | 1.5-2.1 at pH7 |
| CAS DataBase Reference | 87-13-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6KF8220SZ8 |
| NIST Chemistry Reference | Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8) |
| EPA Substance Registry System | Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8) |
| UNSPSC Code | 12352200 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-42/43 | |||||||||
| Safety Statements | 26-36/37/39-27-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | OO1100000 | |||||||||
| Autoignition Temperature | 215 °C | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29189090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 2 Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1A |
|||||||||
| Toxicity | LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Diethyl ethoxymethylenemalonate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001792 | Nalidixic acid impurity C EuropePharmacopoeia (EP) Reference Standard | 87-13-8 | Y0001792 | $204 | 2022-05-15 | Buy |
| Sigma-Aldrich | 05689 | Diethyl ethoxymethylenemalonate for LC-MS derivatization, ≥98.0% (GC) | 87-13-8 | 1ml | $31 | 2022-05-15 | Buy |
| TCI Chemical | E0255 | Diethyl Ethoxymethylenemalonate >98.0%(GC) | 87-13-8 | 25mL | $21 | 2026-04-30 | Buy |
| TCI Chemical | E0255 | Diethyl Ethoxymethylenemalonate >98.0%(GC) | 87-13-8 | 100mL | $27 | 2026-04-30 | Buy |
| Sigma-Aldrich | D94208 | Diethyl ethoxymethylenemalonate 99% | 87-13-8 | 100g | $53.7 | 2026-04-30 | Buy |
Diethyl ethoxymethylenemalonate Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Safety Profile
Moderately toxic by ingestion. A skin irritant. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
The synthesis of diethyl ethoxymethylidenemalonate is usually carried out using diethyl malonate and triethyl orthoformate in a condensation reaction and the removal of a molecule of ethanol to obtain the condensation intermediate, which then eliminates a molecule of ethanol to obtain diethyl ethoxymethylidenemalonate.
Purification Methods
Likely impurity is diethyl diethoxymethylene malonate which is difficult to separate from diethyl ethoxymethylene malonate by distillation, and it is necessary to follow the course of the distillation by the change in refractive index instead of boiling point. After a low boiling fraction is collected, there is obtained an intermediate fraction (n 20 1.414—1.458), the size of which depends on the amount of the diethoxymethylene compound. This fraction is fractionated through a 5inch Vigreux column (p 11) at low pressure avoiding interruption in heating. Fraction b 108-110o/0.25mm is ca 10o lower than the submitters' fraction (b 97.2o/0.25mm, n D 1.4612—1.4623) [Org Synth Coll Vol III 395 1955, Fuson et al. J Org Chem 11 197 1946, Duff & Kendal J Chem Soc 893 1948]. [Beilstein 3 IV 1192.]
Diethyl ethoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 671 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
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View Lastest Price from Diethyl ethoxymethylenemalonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-01 | Diethyl ethoxymethylenemalonate
87-13-8
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-04-24 | Diethyl ethoxymethylenemalonate
87-13-8
|
US $6.30 / KG | 200Kg/Drum | 98% | 100T | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-01-04 | Diethyl ethoxymethylenemalonate
87-13-8
|
US $0.00-0.00 / kg | 1kg | 99.0% min | 20tons/month | Hangzhou ICH Biofarm Co., Ltd |
-
- Diethyl ethoxymethylenemalonate
87-13-8
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Diethyl ethoxymethylenemalonate
87-13-8
- US $6.30 / KG
- 98%
- Baoji Guokang Healthchem Co., Ltd.
-
- Diethyl ethoxymethylenemalonate
87-13-8
- US $0.00-0.00 / kg
- 99.0% min
- Hangzhou ICH Biofarm Co., Ltd
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