Econazole nitrate
- CAS No.
- 24169-02-6
- Chemical Name:
- Econazole nitrate
- Synonyms
- ECONAZOL NITRATE;Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril
- CBNumber:
- CB3173103
- Molecular Formula:
- C18H16Cl3N3O4
- Molecular Weight:
- 444.7
- MDL Number:
- MFCD00058160
- MOL File:
- 24169-02-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 162°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1)) |
| form | powder |
| color | white to off-white |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 14,3502 |
| InChI | InChI=1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4) |
| InChIKey | DDXORDQKGIZAME-UHFFFAOYSA-N |
| SMILES | C1(C(Cl)=CC(Cl)=CC=1)C(OCC1=CC=C(Cl)C=C1)CN1C=NC=C1.[N+]([O-])(=O)O |
| CAS DataBase Reference | 24169-02-6(CAS DataBase Reference) |
| EWG's Food Scores | 2 |
| FDA UNII | H438WYN10E |
| EPA Substance Registry System | Econazole mononitrate (24169-02-6) |
| UNSPSC Code | 51102829 |
| NACRES | NA.85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/38-36/37/38 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI4450000 | |||||||||
| HS Code | 29332900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont) | |||||||||
| NFPA 704 |
|
Econazole nitrate price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E4632 | Econazole nitrate salt | 24169-02-6 | 5g | $83.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | E4632 | Econazole nitrate salt | 24169-02-6 | 25g | $359 | 2026-04-30 | Buy |
| TCI Chemical | E0957 | Econazole Nitrate >98.0%(HPLC)(T) | 24169-02-6 | 5g | $56 | 2026-04-30 | Buy |
| TCI Chemical | E0957 | Econazole Nitrate >98.0%(HPLC)(T) | 24169-02-6 | 25g | $197 | 2026-04-30 | Buy |
| Cayman Chemical | 20223 | Econazole (nitrate) ≥98% | 24169-02-6 | 1g | $28 | 2026-04-30 | Buy |
Econazole nitrate Chemical Properties,Uses,Production
Preparation
In a 500mL four-necked reaction flask equipped with a mechanical stirrer and reflux condenser, add 51.4g imidazole ethanol, 35g anhydrous potassium carbonate, 105g isopropanol I, 1.5g TBAB, and 3.5g BF4. Heat under reflux for 1 hour, cool to 75℃, add 34g p-chlorobenzyl chloride, and react at 72±1℃ for 4.0 hours. Filter, recover isopropanol by vacuum distillation, add 160g toluene and 20% NaOH solution, stir, wash with water until neutral, and distill the supernatant under vacuum to obtain free alkaline oil. Dissolve in 140g isopropanol II, and acidify with 18g of 68% concentrated nitric acid and 23g of water to prepare 30% dilute nitric acid until precipitation stops. Filter, wash with water, and dry to obtain crude econazole nitrate.
The crude econazole nitrate and 230g of 95% ethanol were added to a 500mL four-necked reaction flask equipped with a mechanical stirrer and a reflux condenser. The mixture was stirred and heated until the crude econazole nitrate was completely dissolved. After slightly cooling, an appropriate amount of activated carbon was added, and the mixture was refluxed for 30 minutes. The mixture was then hot-filtered, allowed to cool naturally to room temperature, and then cooled to 5°C in an ice-water mixture. White crystals precipitated. These were filtered, and the filter cake was dried at 60°C to constant weight, yielding 72.5g of econazole nitrate, with a yield of 81.6%, a melting point of 164.2–164.9°C, and a purity of 99.95%.Description
Econazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.
References
http://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Econazole
http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731
Chemical Properties
White to Off-White Solid
Originator
Pevaryl,Cilag Chemie,France,1976
Uses
Antifungal;Ergosterol synthesis inhibition
Uses
Azole antifungal
Uses
Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.
Manufacturing Process
A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.
brand name
Spectazole (Johnson & Johnson).
Therapeutic Function
Antifungal
General Description
White crystalline powder.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.
Biochem/physiol Actions
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
Econazole nitrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei widely chemical technology Co., Ltd. | 027-83991130 18627774460 | 1718093273@QQ.COM | China | 1618 | 58 |
| Wuhan Linglingjiu Biotechnology Co., Ltd | 15623309010 | 1287744812@qq.com | China | 960 | 58 |
| Wuhan Biocar Pharmacy CO.,Ltd. | 86-027-86589876 15377519203 | 2094286327@qq.com | China | 548 | 58 |
| Klong Industrial Co., Ltd | 519-68231162 13961227312 | info@klongchem.com | China | 166 | 58 |
| Zhongxiang Yaowei Biological Technology Co., Ltd. | 15337241005 13260682861;15337241005 | w13260682861@qq.com | China | 2335 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from Econazole nitrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Econazole nitrate
24169-02-6
|
1KG | 99%~101.0% | 800kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-12 | Econazole nitrate
24169-02-6
|
$2658.00 | 25KG | 99% | 1T | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-08-08 | Econazole nitrate
24169-02-6
|
$29.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- Econazole nitrate
24169-02-6
- $0.00
- 99%~101.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Econazole nitrate
24169-02-6
- $2658.00
- 99%
- Baoji Guokang Healthchem Co., Ltd.
-
- Econazole nitrate
24169-02-6
- $29.00
- 99.90%
- TargetMol Chemicals Inc.
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