ChemicalBook >> CAS DataBase List >>A 769662

A 769662

A 769662 structure

CAS No.: 844499-71-4

Chemical Name:: A 769662

Synonyms: CS-18;A 769662;A-769622;A-769662, >=98%;A-769662/A769662;A-769662, 10 mM in DMSO;AMPK Signaling Activator XV;A 769662 ISO 9001：2015 REACH;A 769662, AMP-activated protein kinase activator;A 769662 (This product is unavailable in the U.S.)

CBNumber:: CB31871930

Molecular Formula:: C20H12N2O3S

Molecular Weight:: 360.39

MDL Number:: MFCD11977269

MOL File:: 844499-71-4.mol

Last updated:2026-01-07 13:58:53

Product description	Number	Pack Size	Price
A-769662 ≥98% (HPLC)	SML2578	5mg	$99.75
A-769662 ≥98% (HPLC)	SML2578	25mg	$385.7
A 769662	H1552	10MG	$171
A 769662	H1552	50MG	$513
A-769662 ≥98%	11900	5mg	$69
More product size

Request For Quotation

A 769662 Properties

Melting point	263 - 266oC
Boiling point	630.1±55.0 °C(Predicted)
Density	1.56
Flash point	334.9℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form	solid
pka	4.50±1.00(Predicted)
color	Beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII	P68477CD2C
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H312-H332-H319

Precautionary statements

P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P

Safety Statements

24/25

HS Code

29333990

NFPA 704

	0
3		0

A 769662 price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2578	A-769662 ≥98% (HPLC)	844499-71-4	5mg	$99.75	2025-07-31	Buy
Sigma-Aldrich	SML2578	A-769662 ≥98% (HPLC)	844499-71-4	25mg	$385.7	2025-07-31	Buy
TCI Chemical	H1552	A 769662	844499-71-4	10MG	$171	2025-07-31	Buy
TCI Chemical	H1552	A 769662	844499-71-4	50MG	$513	2025-07-31	Buy
Cayman Chemical	11900	A-769662 ≥98%	844499-71-4	5mg	$69	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML2578	5mg	$99.75	Buy
SML2578	25mg	$385.7	Buy
H1552	10MG	$171	Buy
H1552	50MG	$513	Buy
11900	5mg	$69	Buy

A 769662 Chemical Properties,Uses,Production

Description

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC₅₀ = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr¹⁷². A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

Uses

A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Definition

ChEBI: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile is a member of biphenyls.

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .

storage

+4°C

Background

A-769662 is a potent activator of AMP-activated protein kinase by allosterically binding to the β and γ subunits and by inhibiting dephosphorylation of AMPK on Thr172. This small molecule selectively targets AMPK heterotrimers containing the β1 subunit. A-769662 has been shown to stimulate purified rat liver AMPK and inhibit fatty acid synthesis in rat hepatocytes. Treatment of adipocytes with A-769662 inhibits cell differentiation, leads to over-activation of AMPK, and inactivation of acetyl-CoA carboxylase, making this an interesting compound when studying obesity.

References

[1] JOHN W SCOTT. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.[J]. Chemistry & biology, 2008, 15 11: 1220-1230. DOI:10.1016/j.chembiol.2008.10.005
[2] BARBARA COOL. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.[J]. Cell metabolism, 2006, 3 6: 403-416. DOI:10.1016/j.cmet.2006.05.005
[3] YI ZHOU. Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis.[J]. Biological & pharmaceutical bulletin, 2009, 32 6: 993-998. DOI:10.1248/bpb.32.993
[4] ALEJANDRO VAZQUEZ-MARTIN. Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.[J]. Cell Cycle, 2012, 11 5: 974-989. DOI:10.4161/cc.11.5.19450
[5] SERGE DUCOMMUN. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.[J]. American journal of physiology. Endocrinology and metabolism, 2014, 306 6: E688-96. DOI:10.1152/ajpendo.00672.2013

A 769662 Preparation Products And Raw materials

Raw materials

Preparation Products

A 769662 Suppliers

Global( 200)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20213	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from A 769662 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-08	A-769662 844499-71-4	US $33.00-72.00 / mg		98.72%	10g	TargetMol Chemicals Inc.
2025-11-18	A 769662 844499-71-4	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2021-07-02	4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile 844499-71-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

A-769662
844499-71-4
US $33.00-72.00 / mg
98.72%
TargetMol Chemicals Inc.

A 769662
844499-71-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile
844499-71-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

A 769662 Spectrum

A 769662(844499-71-4)¹HNMR

844499-71-4(A 769662)Related Search:

PD 0325901 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM BIO Glibenclamide (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE

2,2-diphenyl-1-picrylhydrazyl RUETASOLV BP 4103 - MIXTURE OF ISOMERES ISOPROPYLBIPHENYLS. FOR FURTHER DETAILS PLEASE INQUIRE AT MARKETING CONTACTS. SPECIALITY CHEMICALS 4,4'-Biphenol 3-PHENYLPHENOL 4-Phenylphenol

BML-275 BIRB 796 (Doramapimod) AICAR Ibrutinib CHIR-99021

1of3

A 769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile CS-18 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo- A-769662/A769662 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri A-769622 A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile A-769662, >=98% 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboni 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6 4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile A 769662 (This product is unavailable in the U.S.) A 769662 ISO 9001：2015 REACH 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile A 769662, AMP-activated protein kinase activator A-769662, 10 mM in DMSO AMPK Signaling Activator XV 844499-71-4 C20H12N2O3S Inhibitors Akt mTOR PI3K APIs Signalling