METHYL ISOXAZOLE-5-CARBOXYLATE
- CAS No.
- 15055-81-9
- Chemical Name:
- METHYL ISOXAZOLE-5-CARBOXYLATE
- Synonyms
- AKOS PAO-1372;methyl 5-isoxazolcarboxylate;methyl oxazole-5-carboxylate;METHYL ISOXAZOLE-5-CARBOXYLATE;methyl 1,2-oxazole-5-carboxylate;5-Isoxazolecarboxylic acid, Methyl ester;ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER;methyl isoxazole-5-carboxylate - [M83091];Isoxazole-5-carboxylic acid ethyl ester;Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
- CBNumber:
- CB3191387
- Molecular Formula:
- C5H5NO3
- Molecular Weight:
- 127.1
- MDL Number:
- MFCD01570794
- MOL File:
- 15055-81-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
METHYL ISOXAZOLE-5-CARBOXYLATE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I918115 | 5-IsoxazolecarboxylicAcidMethylEster | 15055-81-9 | 1g | $140 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H23-1-72 | Methyl isoxazole-5-carboxylate | 15055-81-9 | 5G | $336 | 2021-12-16 | Buy |
| AK Scientific | W3292 | Methylisoxazole-5-carboxylate | 15055-81-9 | 25g | $1171 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H23-1-72 | Methyl isoxazole-5-carboxylate | 15055-81-9 | 1g | $104 | 2021-12-16 | Buy |
METHYL ISOXAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production
Uses
5-Isoxazolecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of pyridine derivatives as integrase inhibitors and antiviral agents. 5-Isoxazolecarboxylic Acid Methyl Ester is also a useful synthetic intermediate in the preparation of pyrazolopyrimidine derivatives useful in the prevention and treatment of cancer.
Synthesis
21169-71-1
74-88-4
15055-81-9
A mixture of isoxazole-5-carboxylic acid (2.5 g, 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted for 19 hr at 25 °C. After completion of the reaction, the mixture was diluted with deionized water (30 mL) and extracted with ether (2 × 50 mL). The combined organic layers were washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by a Biotage fast chromatography system (40 m column) with the eluent of ethyl acetate-hexane (1:2, v/v), followed by switching to pure ethyl acetate, resulting in methyl isoxazole-5-carboxylate as an amorphous solid (1.2 g, 42.7% yield). Mass spectrum (+ESI): m/z 128 [M+H]+.
References
[1] Patent: US2007/219186, 2007, A1. Location in patent: Page/Page column 51
METHYL ISOXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL ISOXAZOLE-5-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12248 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 12931 | 58 |
| GLR Innovations | +91 9891111994 | info@glrgroup.in | India | 4535 | 58 |
View Lastest Price from METHYL ISOXAZOLE-5-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-11 | METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2020-02-01 | METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
|
US $1.00 / KG | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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