Methyl isoxazole-5-carboxylate
- CAS No.
- 15055-81-9
- Chemical Name:
- Methyl isoxazole-5-carboxylate
- Synonyms
- methyl oxazole-5-carboxylate;AKOS PAO-1372;methyl 5-isoxazolcarboxylate;Methyl isoxazole-5-carboxylate;methyl 1,2-oxazole-5-carboxylate;ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER;5-Isoxazolecarboxylic acid, Methyl ester;methyl isoxazole-5-carboxylate - [M83091];Isoxazole-5-carboxylic acid ethyl ester;Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
- CBNumber:
- CB3191387
- Molecular Formula:
- C5H5NO3
- Molecular Weight:
- 127.1
- MDL Number:
- MFCD01570794
- MOL File:
- 15055-81-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Methyl isoxazole-5-carboxylate price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 436792 | 5-Isoxazolecarboxylic Acid Methyl Ester | 15055-81-9 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 436792 | 5-Isoxazolecarboxylic Acid Methyl Ester | 15055-81-9 | 500mg | $425 | 2026-06-03 | Buy |
| Activate Scientific | AS213900 | Methyl Isoxazole-5-carboxylate 97% | 15055-81-9 | 1g | $100 | 2026-06-04 | Buy |
| Activate Scientific | AS213900 | Methyl Isoxazole-5-carboxylate 97% | 15055-81-9 | 5g | $219 | 2026-06-04 | Buy |
| Activate Scientific | AS213900 | Methyl Isoxazole-5-carboxylate 97% | 15055-81-9 | 25g | $909 | 2026-06-04 | Buy |
Methyl isoxazole-5-carboxylate Chemical Properties, Uses, Production
Uses
5-Isoxazolecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of pyridine derivatives as integrase inhibitors and antiviral agents. 5-Isoxazolecarboxylic Acid Methyl Ester is also a useful synthetic intermediate in the preparation of pyrazolopyrimidine derivatives useful in the prevention and treatment of cancer.
Synthesis
21169-71-1
74-88-4
15055-81-9
A mixture of isoxazole-5-carboxylic acid (2.5 g, 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted for 19 hr at 25 °C. After completion of the reaction, the mixture was diluted with deionized water (30 mL) and extracted with ether (2 × 50 mL). The combined organic layers were washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by a Biotage fast chromatography system (40 m column) with the eluent of ethyl acetate-hexane (1:2, v/v), followed by switching to pure ethyl acetate, resulting in methyl isoxazole-5-carboxylate as an amorphous solid (1.2 g, 42.7% yield). Mass spectrum (+ESI): m/z 128 [M+H]+.
References
[1] Patent: US2007/219186, 2007, A1. Location in patent: Page/Page column 51
Methyl isoxazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl isoxazole-5-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Fengchen Chem Co., Ltd. | +86 (21) 13764690794 657056093 | sales@shfcchem.com | China | 95 | 58 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Methyl isoxazole-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2020-02-01 | METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
|
$1.00 | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- METHYL ISOXAZOLE-5-CARBOXYLATE
15055-81-9
- $1.00
- 98%
- Career Henan Chemical Co
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