Dequalinium chloride
- CAS No.
- 522-51-0
- Chemical Name:
- Dequalinium chloride
- Synonyms
- DECA;Dequalinium chloride for performance test CRS;dequadin;Dequalinum;dequafungan;DEQUALINIUM DICHLORIDE;Dequalinium chloride CRS;DEQUALINIUM CHLORIDE HYDRATE;efisol;evazol
- CBNumber:
- CB3193093
- Molecular Formula:
- C30H40Cl2N4
- Molecular Weight:
- 527.57
- MDL Number:
- MFCD00063502
- MOL File:
- 522-51-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dequalinium chloride Pharmaceutical Secondary Standard; Certified Reference Material | PHR1300 | 500mg | $153 |
| Dequalinium chloride European Pharmacopoeia (EP) Reference Standard | D0430000 | d0430000 | $220 |
| Dequalinium (chloride) ≥95% | 17557 | 250mg | $131 |
| Dequalinium (chloride) ≥95% | 17557 | 500mg | $249 |
| Dequalinium (chloride) ≥95% | 17557 | 1g | $471 |
| More product size | |||
| Melting point | ≥300 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water and in ethanol (96 per cent). |
| form | Solid |
| color | Beige |
| Merck | 13,2930 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions |
ANTIMICROBIAL ANTIPLAQUE DEODORANT ORAL CARE |
| InChIKey | LTNZEXKYNRNOGT-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC1=C(C=C(C)[N+]=2CCCCCCCCCC[N+]1C(C)=CC(N)=C2C=CC=CC=12)N.[Cl-].[Cl-] |
| CAS DataBase Reference | 522-51-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | XYS8INN1I6 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VA0700000 | |||||||||
| F | 8 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Dequalinium chloride price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1300 | Dequalinium chloride Pharmaceutical Secondary Standard; Certified Reference Material | 522-51-0 | 500mg | $153 | 2026-04-30 | Buy |
| Sigma-Aldrich | D0430000 | Dequalinium chloride European Pharmacopoeia (EP) Reference Standard | 522-51-0 | d0430000 | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 17557 | Dequalinium (chloride) ≥95% | 522-51-0 | 250mg | $131 | 2026-04-30 | Buy |
| Cayman Chemical | 17557 | Dequalinium (chloride) ≥95% | 522-51-0 | 500mg | $249 | 2026-04-30 | Buy |
| Cayman Chemical | 17557 | Dequalinium (chloride) ≥95% | 522-51-0 | 1g | $471 | 2026-04-30 | Buy |
Dequalinium chloride Chemical Properties,Uses,Production
Description
Dequalinium Chloride is a a potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 mM).
Chemical Properties
White or yellowish-white powder, hygroscopic.
Originator
Dequsan,Sante
Uses
Dequalinium Chloride is a quaternary ammonium cation and the active ingredient in various medications including antiseptic and anti-malarial agents.
Definition
ChEBI: Dequalinium chloride is an organic chloride salt that is the dichloride salt of dequalinium. It has a role as an antiseptic drug, a mitochondrial NADH:ubiquinone reductase inhibitor, an antifungal agent and an antineoplastic agent. It contains a dequalinium.
Manufacturing Process
a) 15 g of 4-aminoquinaldine, 15 g of decamethylene diiodide and 200 ml of
methyl ethyl ketone were refluxed together for 400 hours. The mixture was
allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone,
and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from
ethyl alcohol containing a little methyl alcohol.
b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml
of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The
mixture was allowed to cool, the precipitate filtered off, washed with methyl
ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride)
recrystallized from ethyl alcohol containing a little methyl alcohol.
b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml
of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The
mixture was allowed to cool, the precipitate filtered off, washed with methyl
ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride)
recrystallized from ethyl alcohol containing a little methyl alcohol.
brand name
Decabis;Dequacaine;Dequafungan;Dequin;Faringina;Gargilon;Grocreme;Labosept;Maltyl;Phylletten;Soor-gel;Sorot;Tetesept.
Therapeutic Function
Antiseptic, Antifungal
World Health Organization (WHO)
Skin reactions to dequalinium chloride, including necrotic lesions, have been reported. It remains available as a mouth and throat disinfectant in many countries.
General Description
Dequalinium Chloride is a topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.
Biological Activity
Dequalinium is a quaternary ammonium cation with diverse biological activities. It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 μg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 μg/ml). Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Item No. 17150). In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.
References
1) Miyataet al.(2014),Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1; Proc. Natl. Acad. Sci. USA11114406
2) Frey Tirriet al.(2011),Antimicrobial topical agents used in the vagina; Curr. Probl. Dermatol.4036
3) Castleet al.(1993),Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle; Eur. J. Pharmacol.236201
4) Orzaezet al.(2011),Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain; Apoptosis16460
Dequalinium chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from Dequalinium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-15 | Dequalinium chloride
522-51-0
|
$75.00-100.00 | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-05-18 | Dequalinium chloride
522-51-0
|
$39.00-73.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-18 | Dequalinium chloride
522-51-0
|
$39.00-73.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- Dequalinium chloride
522-51-0
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Dequalinium chloride
522-51-0
- $39.00-73.00
- 99.90%
- TargetMol Chemicals Inc.
-
- Dequalinium chloride
522-51-0
- $39.00-73.00
- 99.90%
- TargetMol Chemicals Inc.
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