N-Boc-3-Cyanopiperidine
- CAS No.
- 91419-53-3
- Chemical Name:
- N-Boc-3-Cyanopiperidine
- Synonyms
- 1-Boc-3-cyanopiperidine;N-Boc-3-Cyanopiperid;N-BOC-CYANOPIPERIDINE;1-Boc-3-cyanopiperdine;1-Boc-3-cyanopiperidin;N-BOC-3-CYANO-PIPERIDINE;1-N-BOC-3-CYANOPIPERDINE;1-N-BOC-3-CYANOPIPERIDINE;3-cyano-1-N-Boc-piperidine;(R)-N-1-BOC-3-CYANOPIPERDINE
- CBNumber:
- CB3200069
- Molecular Formula:
- C11H18N2O2
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD01861222
- MOL File:
- 91419-53-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Boc-piperidine-3-carbonitrile 95% | 735728 | 1g | $45.6 |
| 1-tert-Butoxycarbonyl-3-cyanopiperidine >98.0%(GC) | B4515 | 1g | $42 |
| 1-tert-Butoxycarbonyl-3-cyanopiperidine >98.0%(GC) | B4515 | 5g | $166 |
| N-Boc-3-Cyanopiperidine | 458289 | 1g | $326 |
| N-Boc-3-Cyanopiperidine | 458289 | 2.5g | $425 |
| More product size | |||
| Melting point | 60-65℃ |
|---|---|
| Boiling point | 40°C/30mmHg(lit.) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| pka | -3.42±0.40(Predicted) |
| form | Powder |
| color | White to yellow |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-5-9(7-12)8-13/h9H,4-6,8H2,1-3H3 |
| InChIKey | UEFZTXGFHKPSFS-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCCC(C#N)C1 |
| CAS DataBase Reference | 91419-53-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36/37/38-50 | |||||||||
| Safety Statements | 26-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
N-Boc-3-Cyanopiperidine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 735728 | 1-Boc-piperidine-3-carbonitrile 95% | 91419-53-3 | 1g | $45.6 | 2023-06-20 | Buy |
| TCI Chemical | B4515 | 1-tert-Butoxycarbonyl-3-cyanopiperidine >98.0%(GC) | 91419-53-3 | 1g | $42 | 2024-03-01 | Buy |
| TCI Chemical | B4515 | 1-tert-Butoxycarbonyl-3-cyanopiperidine >98.0%(GC) | 91419-53-3 | 5g | $166 | 2021-12-16 | Buy |
| Usbiological | 458289 | N-Boc-3-Cyanopiperidine | 91419-53-3 | 1g | $326 | 2026-06-03 | Buy |
| Usbiological | 458289 | N-Boc-3-Cyanopiperidine | 91419-53-3 | 2.5g | $425 | 2026-06-03 | Buy |
N-Boc-3-Cyanopiperidine Chemical Properties,Uses,Production
Uses
N-Boc-3-Cyanopiperidine is an intermediate used to prepare inhibitors of aurora kinases based on the imidazo-[1,2-a]-Pyrazine core.
Synthesis
91419-49-7
91419-53-3
General procedure for the synthesis of tert-butyl 3-cyanopiperidine-1-carboxylate (3) from N-BOC-3-piperidinecarboxamide: To a solution of tert-butyl-3-carbamoylpiperidine-1-carboxylate (2) (1.0 g, 4 mmol) in anhydrous methylene chloride (20 mL) was added triethylamine (3.1 g, 31.0 mmol), followed by a slow, dropwise addition of trifluoroacetic acid anhydride (4.1 g , 20.0 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was partitioned between dichloromethane (50 mL) and water (50 mL). The organic phase was washed with saturated sodium bicarbonate solution (100 mL) and subsequently dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give a viscous liquid product 3 (800 mg, 87% yield).1H NMR (400 MHz, CDCl3) δ 1.49 (s, 9H), 1.77 (m, 2H), 1.97 (brs, 1H), 2.66 (m, 1H), 3.35-3.84 (brs, 4H).
References
[1] Patent: US2009/215822, 2009, A1. Location in patent: Page/Page column 11
[2] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 34
[3] Journal of the American Chemical Society, 2018, vol. 140, # 5, p. 1627 - 1631
[4] Tetrahedron, 2002, vol. 58, # 18, p. 3561 - 3577
[5] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00606
N-Boc-3-Cyanopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8741 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
View Lastest Price from N-Boc-3-Cyanopiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | N-Boc-3-Cyanopiperidine
91419-53-3
|
$1.00 | 1kg | 99% | 200kg | Career Henan Chemical Co |
-
- N-Boc-3-Cyanopiperidine
91419-53-3
- $1.00
- 99%
- Career Henan Chemical Co
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