Methyl 3-amino-4-chlorobenzoate
- CAS No.
- 40872-87-5
- Chemical Name:
- Methyl 3-amino-4-chlorobenzoate
- Synonyms
- 3-AMINO-4-CHLOROBENZOIC ACID METHYL ESTER;Intedanib Impurity 5;Methyl 3-Amino-4-chlorobenzene;METHYL 3-AMINO-4-CHLOROBENZOATE;METHYL, 4-CHLORO-3-AMINOBENZOATE;Methyl3-Amino-4-chlorobenzoate>3-amino-4-chloro-2-methylbenzoate;Amino chlorobenzoic acid methyl ester;Methyl 3-AMino-4-chlorobenzoate, 98.0%(GC&T;Benzoic acid, 3-aMino-4-chloro-, Methyl ester
- CBNumber:
- CB3211933
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD03470533
- MOL File:
- 40872-87-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 3-Amino-4-chlorobenzoate >98.0%(GC)(T) | M1778 | 5g | $53 |
| Methyl 3-Amino-4-chlorobenzoate >98.0%(GC)(T) | M1778 | 25g | $176 |
| METHYL 3-AMINO-4-CHLOROBENZOATE 97% | 37514 | 5G | $22 |
| METHYL 3-AMINO-4-CHLOROBENZOATE 97% | 37514 | 10G | $29 |
| Methyl 3-amino-4-chlorobenzoate | FM70663 | 0.05kg | $150 |
| More product size | |||
| Melting point | 83 °C |
|---|---|
| Boiling point | 292.1±20.0 °C(Predicted) |
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | crystalline powder |
| pka | 1.51±0.10(Predicted) |
| color | Pale lemon/gold |
| InChI | InChI=1S/C8H8ClNO2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,10H2,1H3 |
| InChIKey | LOCJPOYKBUUVKU-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(Cl)C(N)=C1 |
| CAS DataBase Reference | 40872-87-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
Methyl 3-amino-4-chlorobenzoate price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M1778 | Methyl 3-Amino-4-chlorobenzoate >98.0%(GC)(T) | 40872-87-5 | 5g | $53 | 2026-04-30 | Buy |
| TCI Chemical | M1778 | Methyl 3-Amino-4-chlorobenzoate >98.0%(GC)(T) | 40872-87-5 | 25g | $176 | 2026-04-30 | Buy |
| AstaTech | 37514 | METHYL 3-AMINO-4-CHLOROBENZOATE 97% | 40872-87-5 | 5G | $22 | 2026-04-30 | Buy |
| AstaTech | 37514 | METHYL 3-AMINO-4-CHLOROBENZOATE 97% | 40872-87-5 | 10G | $29 | 2026-04-30 | Buy |
| Biosynth | FM70663 | Methyl 3-amino-4-chlorobenzoate | 40872-87-5 | 0.05kg | $150 | 2026-06-04 | Buy |
Methyl 3-amino-4-chlorobenzoate Chemical Properties,Uses,Production
Synthesis
To a solution of 3-amino-4-chlorobenzoic acid (15.0 g, 88.0 mmol) in methanol (90.0 mL), thionyl chloride (13.0 mL) was added drop-wise at 0 °C. The resulting mixture was refluxed for 12h. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was diluted with water (150 mL) and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate (50 mL) and brine solution (50 mL) and dried over sodium sulfate. The organic layer was removed under a rotary evaporator to yield Methyl 3-amino-4-chlorobenzoate (15.0 g, 92.5 per cent) as an off-white solid. 1H NMR (400 MHz, CDC13) δ 3.88 (s, 3H), 4.26 (brs, 2H), 7.29 (d, J = 8.2 Hz, 1H), 7.34-7.37 (dd, J = 1.9, 8.2 Hz, 1H), 7.45 (d, J = 1.9 Hz, 1H).
References
[1] Patent: WO2011/128251, 2011, A1. Location in patent: Page/Page column 201
[2] Patent: US2011/257151, 2011, A1. Location in patent: Page/Page column 74
[3] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00708
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 8, p. 2465 - 2481
[5] Journal of Organic Chemistry, 2003, vol. 68, # 5, p. 2051 - 2053
Methyl 3-amino-4-chlorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 454 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
View Lastest Price from Methyl 3-amino-4-chlorobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-03 | methyl 3-amino-4-chlorobenzoate
40872-87-5
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2019-07-06 | methyl 3-amino-4-chlorobenzoate
40872-87-5
|
$7.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- methyl 3-amino-4-chlorobenzoate
40872-87-5
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- methyl 3-amino-4-chlorobenzoate
40872-87-5
- $7.00
- 99%
- Career Henan Chemical Co
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