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5-Amino-4,6-dichloropyrimidine

5-Amino-4,6-dichloropyrimidine structure

CAS No.: 5413-85-4

Chemical Name:: 5-Amino-4,6-dichloropyrimidine

Synonyms: 4,6-DICHLOROPYRIMIDIN-5-AMINE;NSC 7851;5-AMino-4;AKOS 91433;TIMTEC-BB SBB003920;5-Amino-4,6-dichloro;4,6-dichloro-5-pyrimidinamin;4,6-DICHLORO-5-PYRIMIDINAMINE;5-AMINO-4,6-DICHLOROPYRIMIDINE;5-AMINO-4,6-DICHLOROPYFIMIDINE

CBNumber:: CB3221794

Molecular Formula:: C4H3Cl2N3

Molecular Weight:: 163.99

MDL Number:: MFCD00006108

MOL File:: 5413-85-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:03:13

Product description	Number	Pack Size	Price
5-Amino-4,6-dichloropyrimidine 97%	217735	5g	$77.5
5-Amino-4,6-dichloropyrimidine >98.0%(N)	A1395	1g	$22
5-Amino-4,6-dichloropyrimidine >98.0%(N)	A1395	5g	$39
5-Amino-4,6-dichloropyrimidine Asreported	258471	50g	$396
5-Amino-4,6-dichloropyrimidine Asreported	258471	100g	$586
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5-Amino-4,6-dichloropyrimidine Properties

Melting point	145-148 °C (lit.)
Boiling point	270.44°C (rough estimate)
Density	1.6662 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	2-8°C
solubility	slightly soluble
pka	-3.01±0.26(Predicted)
form	Crystals or Powder
color	Yellow-brown
Water Solubility	slightly soluble
Sensitive	Moisture Sensitive
BRN	126885
InChI	1S/C4H3Cl2N3/c5-3-2(7)4(6)9-1-8-3/h1H,7H2
InChIKey	NIGDWBHWHVHOAD-UHFFFAOYSA-N
SMILES	Nc1c(Cl)ncnc1Cl
CAS DataBase Reference	5413-85-4(CAS DataBase Reference)
NIST Chemistry Reference	5-Amino-4,6-dichloropyrimidine(5413-85-4)
EPA Substance Registry System	5-Pyrimidinamine, 4,6-dichloro- (5413-85-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

10-21

TSCA

TSCA listed

HS Code

29335995

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
1		0

5-Amino-4,6-dichloropyrimidine price More Price(103)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	217735	5-Amino-4,6-dichloropyrimidine 97%	5413-85-4	5g	$77.5	2026-04-30	Buy
TCI Chemical	A1395	5-Amino-4,6-dichloropyrimidine >98.0%(N)	5413-85-4	1g	$22	2026-04-30	Buy
TCI Chemical	A1395	5-Amino-4,6-dichloropyrimidine >98.0%(N)	5413-85-4	5g	$39	2026-04-30	Buy
Usbiological	258471	5-Amino-4,6-dichloropyrimidine Asreported	5413-85-4	50g	$396	2026-06-03	Buy
Usbiological	258471	5-Amino-4,6-dichloropyrimidine Asreported	5413-85-4	100g	$586	2026-06-03	Buy

Product number	Packaging	Price	Buy
217735	5g	$77.5	Buy
A1395	1g	$22	Buy
A1395	5g	$39	Buy
258471	50g	$396	Buy
258471	100g	$586	Buy

5-Amino-4,6-dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

Yellowish-brown crystals or powder

Uses

An intermediate in the production of many biological inhibitors.

Uses

5-Amino-4,6-dichloropyrimidine was used in the synthesis of:

oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides
conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane nucleosides
N(7)-substituted purines
chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine
9-alkyl-6-substituted-purine analogs, potent anticonvulsant agents
pyrimido-oxazepines in a three-step process with microwave heating at 150°C

Synthesis

4316-93-2

5413-85-4

GENERAL METHODS: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the reaction solution was filtered through a diatomaceous earth filter to remove the Pd/C catalyst, and the filtrate was concentrated to give the target product 4,6-dichloro-5-aminopyrimidine [46].

References

[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 1, p. 54 - 58
[2] Tetrahedron, 1988, vol. 44, # 19, p. 6207 - 6216
[3] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 212 - 228
[4] Synlett, 2010, # 20, p. 3019 - 3022
[5] Synthetic Communications, 2007, vol. 37, # 16, p. 2777 - 2786

5-Amino-4,6-dichloropyrimidine synthesis

Synthesis of 5-Amino-4,6-dichloropyrimidine from 4,6-Dichloro-5-nitropyrimidine

5-Amino-4,6-dichloropyrimidine Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Hexane 4,6-Dihydroxypyrimidine N,N-Diisopropylethylamine Trifluoroacetic acid

Phosphorus oxitrichloride Ethyl acetate Nitric acid 5-AMINO-4,6-DIHYDROXYPYRIMIDINE 4,6-Dichloro-5-nitropyrimidine

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Preparation Products

4,5-Diaminopyrimidine 5-Pyrimidinamine, 1,4,5,6-tetrahydro- 2-(5-AMINO-6-CHLORO-PYRIMIDIN-4-YLAMINO)-ETHANOL 6-CHLORO-N4-(4-CHLOROPHENYL)-4,5-PYRIMIDINEDIAMINE 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

6-chloro-N4-ethylpyrimidine-4,5-diamine (R)-1-((5-aMino-6-chloropyriMidin-4-yl)aMino)propan-2-ol 4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE

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5-Amino-4,6-dichloropyrimidine Suppliers

Global( 414)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
Changzhou Carman Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 5-Amino-4,6-dichloropyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	5-Amino-4,6-dichloropyrimidine 5413-85-4	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2021-07-13	5-Amino-4,6-dichloropyrimidine 5413-85-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	5-Amino-4,6-dichloropyrimidine 5413-85-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

5-Amino-4,6-dichloropyrimidine
5413-85-4
$1.10
99.00%
Dideu Industries Group Limited

5-Amino-4,6-dichloropyrimidine
5413-85-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Amino-4,6-dichloropyrimidine
5413-85-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Amino-4,6-dichloropyrimidine Spectrum

5-Amino-4,6-dichloropyrimidine(5413-85-4)MS 5-Amino-4,6-dichloropyrimidine(5413-85-4)¹HNMR 5-Amino-4,6-dichloropyrimidine(5413-85-4)¹³CNMR 5-Amino-4,6-dichloropyrimidine(5413-85-4)IR1 5-Amino-4,6-dichloropyrimidine(5413-85-4)IR2 5-Amino-4,6-dichloropyrimidine(5413-85-4)Raman

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4,6-DICHLORO-5-PYRIMIDINAMINE 4,6-DICHLOROPYRIMIDIN-5-YLAMINE AKOS 91433 5-PYRIMIDINAMINE, 4,6-DICHLORO- 4,6-Dichloro-5-aminopyrimidine 4,6-dichloro-5-pyrimidinamin 5-AMINO-4,6-DICHLOROPYFIMIDINE 5-AMINO-4,6-DICHLOROPYRIMIDINE Pyrimidine, 5-amino-4,6-dichloro- TIMTEC-BB SBB003920 5-Amino-4,6-dichloro 5-AMINO-4,6-DICHLORPYRIMIDIN 97% 5-Amino-4,6-dichloropyrimidine, 98+% 5-amine-4,6-dichloropyrimidine 5-Amino-4,6-dichloropyrimidine,97% 5-AMino-4 5-AMino-4,6-dichloropyriMidine, 97% 1GR NSC 7851 5-AMino-4,6-dichloripyriMidine 5- aMino-4,6-two chloropyriMidine 4,6-Dichloropyrimidin-5-amine, 5-Amino-4,6-dichloro-1,3-diazine 5-Amino-4,6-dichloropyrimidine ISO 9001：2015 REACH 5-Amino-4,6-dichloropyrimidine, 96% {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-imino-1-methyl-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid 4,6-DICHLOROPYRIMIDIN-5-AMINE 5413-85-4 1234-23-6 C4H23C12N3 Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Building Blocks Bases & Related Reagents Heterocycles Nucleotides Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Aromatics Heterocyclic Compounds Heterocycle-Pyrimidine series Pyridines, Pyrimidines, Purines and Pteredines Pyrimidine Pyrimidines bc0001