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Benzomorpholine

Benzomorpholine structure

CAS No.: 5735-53-5

Chemical Name:: Benzomorpholine

Synonyms: 2,3-dihydro-1,4-benzoxazine;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE;AKOS BC-1149;BENZOMORPHOLINE;AKOS BBS-00002717;CHEMBRDG-BB 4005008;benzenebenzomorpholine;3,4-DIHYDRO-2H-1,4-BENZOXAZINE;3,4-Dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 3,4-dihydro-

CBNumber:: CB3231131

Molecular Formula:: C8H9NO

Molecular Weight:: 135.16

MDL Number:: MFCD02181098

MOL File:: 5735-53-5.mol

MSDS File:: SDS

Last updated:2026-05-28 01:03:28

Product description	Number	Pack Size	Price
3,4-Dihydro-2H-1,4-benzoxazine	D5104	1G	$69
3,4-Dihydro-2H-1,4-benzoxazine 97%	AS25560	1g	$25
3,4-Dihydro-2H-1,4-benzoxazine 97%	AS25560	5g	$40
3,4-Dihydro-2H-1,4-benzoxazine ≥95%	OR15168	1g	$28
3,4-Dihydro-2H-1,4-benzoxazine 97%	AS25560	25g	$158
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Benzomorpholine Properties

Boiling point	85°C/0.75mm
Density	1.095±0.06 g/cm3(Predicted)
refractive index	1.60
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	clear liquid
pka	4.37±0.20(Predicted)
color	Colorless to Yellow to Orange
Water Solubility	Sparingly soluble in water.(0.26 g/L) (25°C),
InChI	InChI=1S/C8H9NO/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4,9H,5-6H2
InChIKey	YRLORWPBJZEGBX-UHFFFAOYSA-N
SMILES	O1C2=CC=CC=C2NCC1
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-36/37/39

HazardClass

IRRITANT

HS Code

2934999090

NFPA 704

	1
2		0

Benzomorpholine price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D5104	3,4-Dihydro-2H-1,4-benzoxazine	5735-53-5	1G	$69	2026-04-30	Buy
Activate Scientific	AS25560	3,4-Dihydro-2H-1,4-benzoxazine 97%	5735-53-5	1g	$25	2026-06-04	Buy
Activate Scientific	AS25560	3,4-Dihydro-2H-1,4-benzoxazine 97%	5735-53-5	5g	$40	2026-06-04	Buy
Apolloscientific	OR15168	3,4-Dihydro-2H-1,4-benzoxazine ≥95%	5735-53-5	1g	$28	2026-06-04	Buy
Activate Scientific	AS25560	3,4-Dihydro-2H-1,4-benzoxazine 97%	5735-53-5	25g	$158	2026-06-04	Buy

Product number	Packaging	Price	Buy
D5104	1G	$69	Buy
AS25560	1g	$25	Buy
AS25560	5g	$40	Buy
OR15168	1g	$28	Buy
AS25560	25g	$158	Buy

Benzomorpholine Chemical Properties,Uses,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Definition

ChEBI: 3,4-Dihydro-2H-1,4-benzoxazine is a benzoxazine.

Synthesis

106-93-4

95-55-6

5735-53-5

To a suspension of 2-aminophenol (1.0 g, 9.2 mmol) and potassium carbonate (6.36 g, 46 mmol) in anhydrous DMF (10 mL) was added 1,2-dibromoethane (2.59 g, 13.8 mmol). The reaction mixture was heated at 125 °C with stirring for 15 hours. After completion of the reaction, it was cooled to room temperature, the mixture was poured into crushed ice and extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:10, v/v) as eluent to afford 3,4-dihydro-2H-benzo[b][1,4]oxazine as a red oil (0.81 g, 65% yield). The product was analyzed by LC-MS (ES-API): retention time 7.51 min; calculated value C8H9NO [M+H]+ 136.1, measured value 136.1.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 44, p. 7823 - 7826
[2] Patent: WO2011/47432, 2011, A1. Location in patent: Page/Page column 88
[3] Heterocyclic Communications, 2012, vol. 18, # 3, p. 143 - 146
[4] Patent: WO2010/51374, 2010, A1. Location in patent: Page/Page column 132
[5] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 13

Benzomorpholine synthesis

Synthesis of Benzomorpholine from 2-(2-nitrophenoxy)acetonitrile

Benzomorpholine Preparation Products And Raw materials

Raw materials

2-(2-nitrophenoxy)acetonitrile Benzene, 1-(2,2-diethoxyethoxy)-2-nitro- 1-(2,3-dihydro-1,4-benzoxazin-4-yl)ethanone 2-(2-BroMo-phenylaMino)-ethanol Allyl 2-nitrophenyl ether

1-(2-BROMOETHOXY)-2-NITROBENZENE 2-(2-CHLOROETHOXY)NITROBENZENE 2-(2-Amino-phenoxy)-ethanol 3(2H)-benzofuranone, oxime, (3Z)- 4-Methyl-2,3-dihydro-1,4-benzoxazine

2H-1,4-BENZOXAZIN-3(4H)-ONE 2-Aminophenol 1,2-Dibromoethane

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Preparation Products

4-Chloro-3-hydroxybenzoyl chloride

Benzomorpholine Suppliers

Global( 156)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16512	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3991	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from Benzomorpholine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	3,4-Dihydro-2H-1,4-benzoxazine 5735-53-5	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-04-04	Benzomorpholine 5735-53-5		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-01-05	Benzomorpholine 5735-53-5		1g	98%min	100kgs/month	Shanghai Rlavie Technology Co ltd

3,4-Dihydro-2H-1,4-benzoxazine
5735-53-5
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Benzomorpholine
5735-53-5
98%
Henan Aochuang Chemical Co.,Ltd.

Benzomorpholine
5735-53-5
98%min
Shanghai Rlavie Technology Co ltd

Benzomorpholine Spectrum

Benzomorpholine(5735-53-5)¹HNMR

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Benzothiazole-2-acetonitrile Levofloxacin Azasetron hydrochloride

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7-Oxa-10-azabicyclo[4.4.0]deca-1,3,5-triene AKOS BC-1149 AKOS BBS-00002717 Benzomorpholine(3,4-Dihydro-2H-1,4-benzoxazine) 3,4-DIHYDRO-2H-1,4-BENZOXAZINE BENZOMORPHOLINE CHEMBRDG-BB 4005008 3,4-Dihydro-2H-1,4-benzoxazine hydrochloride 3,4-Dihydro-2H-1,4-benzoxazine, 97+% 3,4-dihydro-2H-1,4-benzoxazine(SALTDATA: FREE) 3,4-Dihydro-2H-benzo[1,4]oxazine 2H-1,4-Benzoxazine, 3,4-dihydro- benzenebenzomorpholine 2,3-dihydro-1,4-benzoxazine 3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE 5735-53-5 pharmacetical Heterocycles series