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N-(4-Bromobutyl)phthalimide

N-(4-Bromobutyl)phthalimide structure

CAS No.: 5394-18-3

Chemical Name:: N-(4-Bromobutyl)phthalimide

Synonyms: 2-(4-BROMOBUTYL)ISOINDOLINE-1,3-DIONE;2-(4-BROMOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE;2-(4-broMobutyl)-2,3-dihydro-1H-isoindole-1,3-dione;SKL282;AKOS 92204;N-(4-BromobutyL;RSYY(Apremilast)-7;4-Bromobutylphthalimide;N-Bromobutylphthalimide;Intermediate Impurity 67

CBNumber:: CB3233610

Molecular Formula:: C12H12BrNO2

Molecular Weight:: 282.13

MDL Number:: MFCD00005905

MOL File:: 5394-18-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:17:34

Product description	Number	Pack Size	Price
N-(4-Bromobutyl)phthalimide 98%	100919	10g	$171
N-(4-Bromobutyl)phthalimide >95.0%(HPLC)(T)	B1394	5g	$47
N-(4-Bromobutyl)phthalimide >95.0%(HPLC)(T)	B1394	25g	$129
N-(4-Bromobutyl)phthalimide	B682060	10g	$70
N-(4-Bromobutyl)phthalimide	FB32709	25g	$80
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N-(4-Bromobutyl)phthalimide Properties

Melting point	76-80 °C (lit.)
Boiling point	165-170°C 1mm
Density	1.5271 (rough estimate)
refractive index	1.6320 (estimate)
Flash point	165-170°C/1mm
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	-2.15±0.20(Predicted)
form	Powder
color	White to light brown
Water Solubility	Soluble in ethanol. Insoluble in water.
BRN	164119
InChI	1S/C12H12BrNO2/c13-7-3-4-8-14-11(15)9-5-1-2-6-10(9)12(14)16/h1-2,5-6H,3-4,7-8H2
InChIKey	UXFWTIGUWHJKDD-UHFFFAOYSA-N
SMILES	O=C1N(CCCCBr)C(C2=CC=CC=C21)=O
CAS DataBase Reference	5394-18-3(CAS DataBase Reference)
NIST Chemistry Reference	N-(4-bromobutyl)phthalimide(5394-18-3)
UNSPSC Code	12352111
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H315-H319-H341

Precautionary statements

P201-P202-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P308+P313-P405-P501

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29251995

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

N-(4-Bromobutyl)phthalimide price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	100919	N-(4-Bromobutyl)phthalimide 98%	5394-18-3	10g	$171	2026-03-19	Buy
TCI Chemical	B1394	N-(4-Bromobutyl)phthalimide >95.0%(HPLC)(T)	5394-18-3	5g	$47	2026-03-19	Buy
TCI Chemical	B1394	N-(4-Bromobutyl)phthalimide >95.0%(HPLC)(T)	5394-18-3	25g	$129	2026-03-19	Buy
TRC	B682060	N-(4-Bromobutyl)phthalimide	5394-18-3	10g	$70	2021-12-16	Buy
Biosynth Carbosynth	FB32709	N-(4-Bromobutyl)phthalimide	5394-18-3	25g	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
100919	10g	$171	Buy
B1394	5g	$47	Buy
B1394	25g	$129	Buy
B682060	10g	$70	Buy
FB32709	25g	$80	Buy

N-(4-Bromobutyl)phthalimide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

N-(4-Bromobutyl)phthalimide is used in organic synthesis and the production of pharmaceutical. It can react with 1-phenyl-piperazine to get N-[4-(4-phenyl-piperazin-1-yl)-butyl]-phthalimide. It is a useful synthesis reagent used to synthesize B-cyclodextrin derivatives.

reaction suitability

reagent type: cross-linking reagent
reagent type: linker

Synthesis

110-52-1

136918-14-4

5394-18-3

General procedure for the synthesis of N-(4-bromobutyl)phthalimide from 1,4-dibromobutane and 3-hydroxy-1H-isoindol-1-one: phthalimide (148 mg, 1 mmol), 1,4-dibromobutane (1.080 g, 5 mmol) and potassium carbonate (276 mg, 2 mmol) were added to acetone (3 mL) and the reaction mixture was refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was purified by column chromatography using petroleum ether: acetone (40:1) as eluent to afford N-(4-bromobutyl)phthalimide (260 mg, 92% yield) as a white solid.

References

[1] Journal of Organic Chemistry, 2004, vol. 69, # 18, p. 6094 - 6099
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 6, p. 1532 - 1536
[3] Angew. Chem., 2018, vol. 130, # 6, p. 1548 - 1552,5
[4] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 74 - 85
[5] Journal of the Chinese Chemical Society, 2013, vol. 60, # 12, p. 1431 - 1436

N-(4-Bromobutyl)phthalimide synthesis

Synthesis of N-(4-Bromobutyl)phthalimide from 1,4-Dibromobutane and Potassium phthalimide

N-(4-Bromobutyl)phthalimide Preparation Products And Raw materials

Raw materials

2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-1H-isoindole-1,3(2H)-dione 1-Butanol, 1-amino- 1,1-dibromobutane 5-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PENTANOIC ACID N-Chlorophthalimide

2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione SODIUM PHTHALIMIDE 1H-Isoindol-1-one, 3-hydroxy- 1,4-Dibromobutane Potassium phthalimide

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Preparation Products

4-bromobutan-1-amine PHTHALAMIDE

N-(4-Bromobutyl)phthalimide Suppliers

Global( 345)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from N-(4-Bromobutyl)phthalimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	N-(4-Bromobutyl)phthalimide 5394-18-3	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	N-(4-Bromobutyl)phthalimide 5394-18-3	US $35.00-1.10 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-04-04	N-(4-Bromobutyl)phthalimide 5394-18-3	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

N-(4-Bromobutyl)phthalimide
5394-18-3
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

N-(4-Bromobutyl)phthalimide
5394-18-3
US $35.00-1.10 / kg
99%
Henan Fengda Chemical Co., Ltd

N-(4-Bromobutyl)phthalimide
5394-18-3
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

N-(4-Bromobutyl)phthalimide Spectrum

N-(4-Bromobutyl)phthalimide(5394-18-3)MS N-(4-Bromobutyl)phthalimide(5394-18-3)¹HNMR N-(4-Bromobutyl)phthalimide(5394-18-3)¹³CNMR N-(4-Bromobutyl)phthalimide(5394-18-3)IR1 N-(4-Bromobutyl)phthalimide(5394-18-3)IR2 N-(4-Bromobutyl)phthalimide(5394-18-3)Raman

5394-18-3(N-(4-Bromobutyl)phthalimide)Related Search:

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O-Phthalimide Bismaleimide N-Methylphthalimide N-(4-BROMOPHENYL)METHANESULFONAMIDE, 97% N-(2-Hydroxyethyl)acrylamide, HEAA

POLY(ISOBUTYLENE-CO-ISOPRENE), BROMINATED (R)-5-PHTHALIMIDO-2-BROMOVALERIC ACID N-(4-BROMOBUTOXY)PHTHALIMIDE Polyamideimide 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE

DIALIFOS 2-(4-BROMO-3-OXOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE

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AKOS 92204 2-(4-BROMOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE 2-(4-BROMOBUTYL)ISOINDOLINE-1,3-DIONE N-(4-BROMOBUTYL)PHTHALIMIDE 1H-Isoindole-1,3(2H)-dione, 2-(4-bromobutyl)- 1-Phthalimido-4-bromobutane 4-Bromobutylphthalimide N-(omega-Bromobutyl)phthalimide Phthalimide, N-(4-bromobutyl)- N-(4-Bromobutyl)phthalimide, 98+% N-(4-BromobutyL N-methyl-4-N-[4-(N-phthalimido)buty]aminophthalimide 2-(4-Bromobutyl)isoindole-1,3-dione 2-(4-Bromobutyl)-2H-isoindole-1,3-dione N-(4-Brompobutyl)phthalimide N-(4-Bromobutyl)phthalimide 98% 4-phthalimido-1-bromobutane 2-(4-broMobutyl)-2,3-dihydro-1H-isoindole-1,3-dione N-(4-BroMobutyl)phthaliMide, 98% 10GR 2-(4-Bromobut-1-yl)-1H-isoindole-1,3(2H)-dione, 2-(4-Bromobut-1-yl)isoindolin-1,3-dione N-(4-Bromobut-1-yl)phthalimide N-(4-Bromobutyl)phthalimide SKL282 RSYY(Apremilast)-7 N-Bromobutylphthalimide 1-Phthalimido-4-bromobutane, 2-(4-Bromobutyl)-2,3-dihydro-1H-isoindole-1,3-dione, 2-(4-Bromobutyl)phthalimide, 4-Bromobutylphthalimide Intermediate Impurity 67 5394-18-3 C12H12BrNO2 Cyclic Imides Organic Building Blocks N-Substituted Phthalimides N-Substituted Maleimides, Succinimides & Phthalimides Building Blocks Carbonyl Compounds Cyclic Imides Linkers Peptide Synthesis N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides Bifunctional CrosslinkersOrganic Building Blocks Carbonyl Compounds