Hirsutine
- CAS No.
- 7729-23-9
- Chemical Name:
- Hirsutine
- Synonyms
- 16e)-;HIRSUTINE;Methyl (E)-2-[(2;Resorcinol Impurity 28;Hirsutine, 10 mM in DMSO;Mitragynine Impurity 8 (Hirsutine);corynan-16-carboxylicacid,16,17-didehydro-17-methoxy-,methylester,(3-bet;18-seco-3-beta-yohimban-16-carboxylicacid,16,17-didehydro-17-methoxy-1met;(3β,16E)-16,17-Didehydro-17-methoxycorynan-16-carboxylic acid methyl ester;(e)-16,17-didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylicacid
- CBNumber:
- CB3233665
- Molecular Formula:
- C22H28N2O3
- Molecular Weight:
- 368.47
- MDL Number:
- MFCD01750089
- MOL File:
- 7729-23-9.mol
| Melting point | 101 °C |
|---|---|
| Boiling point | 531.7±50.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 18.13±0.60(Predicted) |
| color | White to off-white |
| FDA UNII | W596OF93C7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Hirsutine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300418 | Hirsutine | 7729-23-9 | 5mg | $632 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259292 | Hirsutine 98% | 7729-23-9 | 5mg | $778.6 | 2021-12-16 | Buy |
| ChemScene | CS-0019501 | Hirsutine ≥99.0% | 7729-23-9 | 5mg | $1143 | 2021-12-16 | Buy |
| ChemScene | CS-0019501 | Hirsutine ≥99.0% | 7729-23-9 | 1mg | $381 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0005141 | HIRSUTINE 95.00% | 7729-23-9 | 5MG | $498.11 | 2021-12-16 | Buy |
Hirsutine Chemical Properties,Uses,Production
Uses
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].
Biological Activity
Hirsutine is a brain penetrant alkaloid from Uncaria rhynchophylla th at exhibit anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities. It appears th at hirsutine induces apoptosis in lung cancer cells through opening of mitochondrial permeability transition pore (mPTP). Hirsutine exhibit potent anti-dengue virus activity.
in vivo
Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3].
References
[1] Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674. DOI:10.3389/fmicb.2017.01674
[2] Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46. PMID:29492513
[3] Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598. DOI:10.1038/s41419-018-0641-7
Hirsutine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
View Lastest Price from Hirsutine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-09 | Hirsutine
7729-23-9
|
US $0.00 / mg | 99.36% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-12 | Hirsutine
7729-23-9
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-02-24 | Hirsutine
7729-23-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |