Cloquintocet-mexyl
- CAS No.
- 99607-70-2
- Chemical Name:
- Cloquintocet-mexyl
- Synonyms
- CLOQUINTOCET-1-METHYLHEXYL ESTER;Jiecao ester;Crop safener;Cloquintocet-1;oquintocet-MexyL;cloquitocet_mexyl;CLOQUINTOCET-MEXYL;Cloquintocet-methyl;Adagrasib Impurity 59;Cloquintocet-mexyl >
- CBNumber:
- CB3243431
- Molecular Formula:
- C18H22ClNO3
- Molecular Weight:
- 335.83
- MDL Number:
- MFCD01632329
- MOL File:
- 99607-70-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 69° |
|---|---|
| Boiling point | 448.4±30.0 °C(Predicted) |
| Density | 1.163±0.06 g/cm3(Predicted) |
| vapor pressure | 0-54.4Pa at 25-185.9℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| pka | 1.94±0.29(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,2401 |
| Henry's Law Constant | 1.2×104 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application |
agriculture environmental |
| InChI | 1S/C18H22ClNO3/c1-3-4-5-7-13(2)23-17(21)12-22-16-10-9-15(19)14-8-6-11-20-18(14)16/h6,8-11,13H,3-5,7,12H2,1-2H3 |
| InChIKey | COYBRKAVBMYYSF-UHFFFAOYSA-N |
| SMILES | CCCCCC(C)OC(=O)COc1ccc(Cl)c2cccnc12 |
| LogP | 5.2-5.24 at 25℃ and pH5-9.1 |
| Surface tension | 56.8-57.2mN/m at 590μg/L and 20℃ |
| Dissociation constant | 3.55 at 20℃ |
| CAS DataBase Reference | 99607-70-2(CAS DataBase Reference) |
| FDA UNII | 99W15EH2M3 |
| Pesticides Freedom of Information Act (FOIA) | Cloquintocet mexyl |
| EPA Substance Registry System | Cloquintocet-mexyl (99607-70-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H410 |
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 |
| target organs | Urinary bladder |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| RIDADR | UN 3077 |
| WGK Germany | 2 |
| RTECS | AG1265000 |
| TSCA | TSCA listed |
| HS Code | 2933.49.3000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Inhalation Aquatic Acute 1 Aquatic Chronic 1 Skin Sens. 1 STOT RE 2 Oral |
| Toxicity | LD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein) |
| REACH Registrations | Active |
Cloquintocet-mexyl price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 31678 | Cloquintocet-mexyl PESTANAL | 99607-70-2 | 250mg | $99.6 | 2026-04-30 | Buy |
| TCI Chemical | C2682 | Cloquintocet-mexyl >98.0%(HPLC)(T) | 99607-70-2 | 1g | $39 | 2026-04-30 | Buy |
| ChemScene | CS-5215 | Cloquintocet-mexyl 99.33% | 99607-70-2 | 500mg | $65 | 2026-06-04 | Buy |
| AK Scientific | O792 | Cloquintocet-Mexyl 97%(GC) | 99607-70-2 | 250mg | $27 | 2026-06-04 | Buy |
| AK Scientific | O792 | Cloquintocet-Mexyl 97%(GC) | 99607-70-2 | 1g | $51 | 2026-06-04 | Buy |
Cloquintocet-mexyl Chemical Properties, Uses, Production
Description
Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.
Chemical Properties
beige solid
Uses
Cloquintocet-mexyl is used as a herbicide.
Uses
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.
Definition
ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester.
Production Methods
Cloquintocet-mexyl is commercially produced through a multi-step synthesis starting with 5-chloro-8-hydroxyquinoline as the primary raw material. The process begins with a nucleophilic substitution reaction where 5-chloro-8-hydroxyquinoline reacts with methyl chloroacetate in a solvent such as dimethylformamide, using potassium carbonate or a combination of sodium carbonate and sodium hydroxide as the base to form the intermediate methyl (5-chloro-8-quinolyloxy)acetate, typically at elevated temperatures to drive the alkylation at the 8-position oxygen. This ester is then subjected to alkaline hydrolysis with sodium hydroxide, followed by acidification (e.g., with hydrochloric acid) to yield the free acid, (5-chloro-8-quinolyloxy)acetic acid, which is isolated in high purity to minimize impurities. Finally, the acid undergoes esterification with 2-heptanol in the presence of an acid catalyst like sulfuric acid or p-toluenesulfonic acid, often under Dean-Stark azeotropic distillation conditions to remove water and shift equilibrium, producing cloquintocet-mexyl. An alternative direct transesterification route bypasses hydrolysis by reacting the methyl ester with 2-heptanol under similar catalytic conditions but may suffer lower yields due to equilibrium limitations and potential decomposition above 60DegC.
Agricultural Uses
Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.
Mechanism of action
Accelerates the herbicide detoxification process
Carcinogenicity
In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.
Metabolism
Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.
Toxicity evaluation
Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.
Pesticide Type
Herbicide
Cloquintocet-mexyl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huizhili (Changzhou) Life Technology Co., Ltd | 13906110102 | 13906110102@139.com | China | 15 | 58 |
| XINYI YONGCHENG CHEMICAL INDUSTRIAL CO.,LTD. | 0516-88606028 15952286050 15952286050 | Melodyhl886@163.com | China | 107 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
View Latest Price from Cloquintocet-mexyl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Cloquintocet-mexyl
99607-70-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-05-28 | Cloquintocet-mexyl
99607-70-2
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-11 | Cloquintocet-mexyl
99607-70-2
|
$29.00 | 98.88% | 10g | TargetMol Chemicals Inc. |
-
- Cloquintocet-mexyl
99607-70-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Cloquintocet-mexyl
99607-70-2
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Cloquintocet-mexyl
99607-70-2
- $29.00
- 98.88%
- TargetMol Chemicals Inc.
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