Aminopyrazine
- CAS No.
- 5049-61-6
- Chemical Name:
- Aminopyrazine
- Synonyms
- PYRAZIN-2-AMINE;2-AMINOPYRAZINE;PYRAZINAMINE;APZ;NSC 13147;ENT 60202;PYRAZINEAMINE;AMINOPYRAZINE;2-Pyrazinamine;3-Aminopyrazine
- CBNumber:
- CB3244650
- Molecular Formula:
- C4H5N3
- Molecular Weight:
- 95.1
- MDL Number:
- MFCD00006137
- MOL File:
- 5049-61-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Aminopyrazine 98% | A76958 | 10g | $64.2 |
| Aminopyrazine 98% | A76958 | 50g | $252 |
| 2-Aminopyrazine >98.0%(GC)(T) | A0989 | 5g | $36 |
| 2-Aminopyrazine >98.0%(GC)(T) | A0989 | 25g | $101 |
| 2-Aminopyrazine >98% | 10007093 | 5g | $19 |
| More product size | |||
| Melting point | 118-120 °C (lit.) |
|---|---|
| Boiling point | 167.6°C (rough estimate) |
| Density | 1.1031 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | 3.22±0.10(Predicted) |
| form | Crystalline Powder |
| color | Slightly yellow to beige |
| Water Solubility | soluble |
| BRN | 107025 |
| InChI | 1S/C4H5N3/c5-4-3-6-1-2-7-4/h1-3H,(H2,5,7) |
| InChIKey | XFTQRUTUGRCSGO-UHFFFAOYSA-N |
| SMILES | Nc1cnccn1 |
| LogP | -0.070 |
| CAS DataBase Reference | 5049-61-6(CAS DataBase Reference) |
| FDA UNII | ES73FRK6MY |
| NIST Chemistry Reference | Aminopyrazine(5049-61-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Aminopyrazine price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A76958 | Aminopyrazine 98% | 5049-61-6 | 10g | $64.2 | 2026-03-19 | Buy |
| Sigma-Aldrich | A76958 | Aminopyrazine 98% | 5049-61-6 | 50g | $252 | 2023-06-20 | Buy |
| TCI Chemical | A0989 | 2-Aminopyrazine >98.0%(GC)(T) | 5049-61-6 | 5g | $36 | 2026-03-19 | Buy |
| TCI Chemical | A0989 | 2-Aminopyrazine >98.0%(GC)(T) | 5049-61-6 | 25g | $101 | 2026-03-19 | Buy |
| Cayman Chemical | 10007093 | 2-Aminopyrazine >98% | 5049-61-6 | 5g | $19 | 2024-03-01 | Buy |
Aminopyrazine Chemical Properties,Uses,Production
Chemical Properties
SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER
Uses
2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines.
Application
2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines.
Definition
ChEBI: Aminopyrazine is a member of pyrazines.
Synthesis
19847-12-2
5049-61-6
General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield.
References
[1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014
Aminopyrazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| Nanjing Yushan Wanfang Biotechnology Co., Ltd. | +86-025-84918180 +86-18014482516 | 3552541679@qq.com | China | 997 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
View Lastest Price from Aminopyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Pyrazinamine
5049-61-6
|
US $29.00 / g | 99.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-20 | Pyrazinamine
5049-61-6
|
US $29.00 / g | 99.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-01 | Aminopyrazine
5049-61-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Pyrazinamine
5049-61-6
- US $29.00 / g
- 99.72%
- TargetMol Chemicals Inc.
-
- Pyrazinamine
5049-61-6
- US $29.00 / g
- 99.72%
- TargetMol Chemicals Inc.
-
- Aminopyrazine
5049-61-6
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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