ICG-001
- CAS No.
- 780757-88-2
- Chemical Name:
- ICG-001
- Synonyms
- (S,S)-ICG 001;ICG-001 USP/EP/BP;ICG-001 PRI-724 isomer;(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylMethyl)-;(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrazino[1,2-a]pyrimidine-1-carboxamide;(6S,9AS)-6-(4-HYDROXYBENZYL)-8-NAPHTHALEN-1-YLMETHYL-4,7-DIOXO-HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-1-CARBOXYLIC ACID BENZYLAMIDE;(6S,9aS)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide;(6S,9aS)-6-(4-hydroxybenzyl)-N-benzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxo-hexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide;ICG-001;ICG001;(6S,9AS)-6-(4-HYDROXYBENZYL)-N-BENZYL-8-(NAPHTHALEN-1-YLMETHYL)-4,7-DIOXO-HEXAHYDRO-2H-PYRAZINO[1,2-A]PYRIMIDINE-1(6H)-CARBOXAMIDE;(6R,9aR)-rel-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
- CBNumber:
- CB32457036
- Molecular Formula:
- C33H32N4O4
- Molecular Weight:
- 548.63
- MDL Number:
- MFCD12196918
- MOL File:
- 780757-88-2.mol
- MSDS File:
- SDS
| Melting point | 133-134℃ |
|---|---|
| Boiling point | 895.6±65.0 °C(Predicted) |
| Density | 1.37 |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);54.68(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.88±0.15(Predicted) |
| color | White to off-white |
| InChIKey | HQWTUOLCGKIECB-XZWHSSHBSA-N |
| SMILES | [C@]12([H])CN(CC3=C4C(C=CC=C4)=CC=C3)C(=O)[C@H](CC3=CC=C(O)C=C3)N1C(=O)CCN2C(NCC1=CC=CC=C1)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
ICG-001 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16257 | ICG-001 | 780757-88-2 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 16257 | ICG-001 | 780757-88-2 | 25mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 16257 | ICG-001 | 780757-88-2 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16257 | ICG-001 | 780757-88-2 | 10mg | $138 | 2024-03-01 | Buy |
| TRC | I163895 | ICG001 | 780757-88-2 | 1mg | $45 | 2021-12-16 | Buy |
ICG-001 Chemical Properties,Uses,Production
Uses
ICG 001 is a small molecule inhibitor of Wnt/β-catenin signaling.
Definition
ChEBI: (6S,9aS)-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide is a peptide.
in vivo
ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling in mice, while concurrently preserving the epithelium[2]. Administration of a water-soluble analog of ICG-001 for 9 weeks reduces the formation of colon and small intestinal polyps by 42% as effectively as the nonsteroidal antiinflammatory agent MK-231, which has consistently demonstrated efficacy in this model. ICG-001 (150 mg/kg, i.v.) demonstrates a dramatic reduction in tumor volume over the 19-day course of treatment, with no mortality or weight loss in the SW620 nude mouse xenograft model of tumor regression[3].
storage
-20°C
ICG-001 Preparation Products And Raw materials
Raw materials
Preparation Products
ICG-001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20386 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
