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Deoxyarbutin

Deoxyarbutin structure

CAS No.: 53936-56-4

Chemical Name:: Deoxyarbutin

Synonyms: Tetrahydropyranyloxyphenol;Dexyarbutin;Deoxyarbutin;LGB-D ARBUTIN;Deoxyarbutin, 96%;Deoxyarbutin, 98%+;Deoxyarbutin 53936-56-4;Tranexamic acid 701-54-2;Pure Deoxyarbutin Powder;Deoxyarbutin, 10 mM in DMSO

CBNumber:: CB32473685

Molecular Formula:: C11H14O3

Molecular Weight:: 194.23

MDL Number:: MFCD09970981

MOL File:: 53936-56-4.mol

MSDS File:: SDS

Last updated:2025-09-08 11:55:05

Product description	Number	Pack Size	Price
Deoxyarbutin	21077	10g	$49
Deoxyarbutin	21077	250g	$593
Deoxyarbutin	21077	50g	$216
Deoxyarbutin	21077	100g	$263
Deoxyarbutin	D232105	50mg	$105
More product size

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Deoxyarbutin Properties

Melting point	88-89 °C(Solv: ligroine (8032-32-4))
Boiling point	349.8±32.0 °C(Predicted)
Density	1.174
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	10.10±0.15(Predicted)
form	Solid
color	White to Off-White
Stability	Hygroscopic
InChI	InChI=1S/C11H14O3/c12-9-4-6-10(7-5-9)14-11-3-1-2-8-13-11/h4-7,11-12H,1-3,8H2
InChIKey	GFBCWCDNXDKFRH-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(OC2OCCCC2)C=C1
FDA UNII	RG969BY5EN

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2932990090

NFPA 704

	0
2		0

Deoxyarbutin price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21077	Deoxyarbutin	53936-56-4	10g	$49	2024-03-01	Buy
Cayman Chemical	21077	Deoxyarbutin	53936-56-4	250g	$593	2024-03-01	Buy
Cayman Chemical	21077	Deoxyarbutin	53936-56-4	50g	$216	2024-03-01	Buy
Cayman Chemical	21077	Deoxyarbutin	53936-56-4	100g	$263	2024-03-01	Buy
TRC	D232105	Deoxyarbutin	53936-56-4	50mg	$105	2021-12-16	Buy

Product number	Packaging	Price	Buy
21077	10g	$49	Buy
21077	250g	$593	Buy
21077	50g	$216	Buy
21077	100g	$263	Buy
D232105	50mg	$105	Buy

Deoxyarbutin Chemical Properties,Uses,Production

Description

Deoxyarbutin is a tyrosinase inhibitor (IC₅₀ = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC₅₀ = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

Uses

Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.

Preparation

Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.

Synthesis

110-87-2

123-31-9

53936-56-4

Under nitrogen protection, 3,4-dihydro-2H-pyran (19.1 g, 227.0 mmol) was dissolved in a solution of dichloromethane (200 ml) containing pyridinium p-toluenesulfonate (PPTS) (5.7 g, 22.7 mmol). After cooling the reaction system to 10°C, a solution of hydroquinone (25.0 g, 227.0 mmol) in dichloromethane (100 ml) was added slowly and dropwise. Subsequently, the reaction mixture was gradually warmed to 25°C and stirred continuously for 16 hours. After completion of the reaction, the mixture was poured into water (500 ml) and the aqueous layer was extracted with dichloromethane. The organic layers were combined and washed sequentially with saturated aqueous sodium chloride solution and saturated aqueous sodium bicarbonate solution, then dried with anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=5:1, v/v) to afford 4-((tetrahydro-2H-pyran-2-yl)oxy)phenol (23.2 g, 119.7 mmol, 52.7% yield).

References

[1] Canadian Journal of Chemistry, 2006, vol. 84, # 9, p. 1174 - 1179
[2] Patent: JP5978938, 2016, B2. Location in patent: Paragraph 0149; 0154
[3] Journal of Materials Chemistry, 2012, vol. 22, # 48, p. 25011 - 25018
[4] Patent: US2009/326186, 2009, A1. Location in patent: Page/Page column 64
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 16, p. 4356 - 4360

Deoxyarbutin synthesis

Synthesis of Deoxyarbutin from 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)phenoxy]-

Deoxyarbutin Preparation Products And Raw materials

Raw materials

3,4-Dihydro-2H-pyran 2H-Pyran, tetrahydro-2-[4-(phenylmethoxy)phenoxy]- Hydroquinone Pyridinium p-Toluenesulfonate Dichloromethane

Preparation Products

Deoxyarbutin Suppliers

Global( 384)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Wuhan Fortuna Chemical Co.,Ltd	+86-2759207851; +8618007136271	hk@fortunachem.com	China	5991	58
Xi an Biohorlden Industry Trade Co Ltd	+86-18829283179 +86-13636819721	sales@horlden.com	China	317	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55

Supplier	Advantage
Changzhou Ditong Chemical Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Wuhan Fortuna Chemical Co.,Ltd	58
Xi an Biohorlden Industry Trade Co Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Deoxyarbutin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-16	Deoxyarbutin 53936-56-4	US $0.00 / Kg/Bag	1KG	98%min	3500kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-10-16	Deoxyarbutin 53936-56-4	US $0.00 / Kg/Drum	1KG	99%	200mt	Jinan Finer Chemical Co., Ltd
2025-10-15	Deoxyarbutin 53936-56-4	US $0.00 / KG	1KG	99%	2000KG	Wuhan Fortuna Chemical Co.,Ltd

Deoxyarbutin
53936-56-4
US $0.00 / Kg/Bag
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Deoxyarbutin
53936-56-4
US $0.00 / Kg/Drum
99%
Jinan Finer Chemical Co., Ltd

Deoxyarbutin
53936-56-4
US $0.00 / KG
99%
Wuhan Fortuna Chemical Co.,Ltd

Deoxyarbutin Spectrum

Deoxyarbutin(53936-56-4)¹HNMR

53936-56-4(Deoxyarbutin)Related Search:

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Deoxyarbutin Tetrahydropyranyloxyphenol 4-(TETRAHYDRO-2H-2-PYRANYLOXY)PHENOL 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol Phenol,4-[(tetrahydro-2H-pyran-2-yl)oxy]- Deoxyarbutin 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol 4-[(2-Tetrahydropyranyl)oxy]phenol LGB-D ARBUTIN Deoxyarbutin 53936-56-4 (S)-4-(Tetrahydro-2H-pyran-2-yloxy)phenol Dexyarbutin Deoxyarbutin, 98%+ TIANFUCHEM--53936-56-4--Deoxyarbutin factory price Tranexamic acid 701-54-2 Pure Deoxyarbutin Powder Deoxyarbutin, 10 mM in DMSO Deoxyarbutin, 96% 53936-56-4 3936-56-4 Inhibitors Cosmetics 53936-56-4