Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate
![Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Structure](CAS/GIF/916325-83-2.gif)
- CAS No.
- 916325-83-2
- Chemical Name:
- Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate
- Synonyms
- Methyl 1H-pyrazolo[3,4-b]...;1H-pyrazolo[3,4-b]pyridine-3-carboxylate;Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate;Methyl 2H-pyrazolo[3,4-b]pyridine-3-carboxylate;pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester;2H-pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester;1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, Methyl ester
- CBNumber:
- CB32485596
- Molecular Formula:
- C8H7N3O2
- Molecular Weight:
- 177.16
- MDL Number:
- MFCD13176786
- MOL File:
- 916325-83-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RLB32583 | Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate | 916325-83-2 | 1g | $649 | 2026-06-05 | Buy |
| Biosynth | RLB32583 | Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate | 916325-83-2 | 2g | $973.5 | 2026-06-05 | Buy |
| Biosynth | RLB32583 | Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate | 916325-83-2 | 5g | $1427.8 | 2026-06-05 | Buy |
| Biosynth | RLB32583 | Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate | 916325-83-2 | 10g | $2141.7 | 2026-06-05 | Buy |
| Matrix Scientific | 068504 | 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester | 916325-83-2 | 1.00g | $385 | 2026-05-18 | Buy |
Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Chemical Properties, Uses, Production
Synthesis
67-56-1
![1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)](/CAS/GIF/116855-08-4.gif)
116855-08-4
![Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate](/CAS/GIF/916325-83-2.gif)
916325-83-2
Step 5: To a solution of 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (V) (0.39 g, 2.4 mmol) in anhydrous methanol (10 mL) was slowly added concentrated sulfuric acid (4 drops) and the reaction was refluxed under nitrogen protection for 6 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was partitioned between dichloromethane and saturated sodium bicarbonate solution. The organic layer was separated, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (elution gradient: 100% dichloromethane → 100:3 dichloromethane:methanol) to afford methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate (VI) as a white solid (382 mg, 2.16 mmol, 90% yield).1H NMR (CDCl3) δ ppm: 4.08 (s, 3H) 7.38 (m, 1H), 8.63 (dd, J = 8.10, 1.51 Hz, 1H), 8.72 (dd, J = 4.62, 1.41 Hz, 1H); ESIMS m/z: 178.2 ([M + H]+).
References
[1] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 112
[2] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0497
[3] Patent: US2016/68550, 2016, A1. Location in patent: Paragraph 1059
[4] Patent: WO2016/40193, 2016, A1. Location in patent: Paragraph 0706
[5] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 31
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