5-Trifluoromethylpyridine-3-boronic acid pinacol ester
- CAS No.
- 1084953-47-8
- Chemical Name:
- 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
- Synonyms
- 5-trifluoromethylpyridine-3-borate;5-Trifluoromethylpyridine-3-boronic acid picol ester;5-Trifluoromethylpyridine-3-boronic acid pinacol ester;[5-TRIFLUOROMETHYLPYRIDINE-3-BORONIC ACID PICOL ESTER];5-(Trifluoromethyl)pyridine-3-boronic acid, pinacol ester 98%;5-Trifluoromethylpyridine-3-boronic acid pinacol ester - [T10602];3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine;3-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(trifluoromethyl)pyridin-3-yl)boronate
- CBNumber:
- CB32499719
- Molecular Formula:
- C12H15BF3NO2
- Molecular Weight:
- 273.06
- MDL Number:
- MFCD12198142
- MOL File:
- 1084953-47-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | T10602 | 1g | $35 |
| 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | T10602 | 5g | $140 |
| 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | T10602 | 10g | $260 |
| 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine 98% | AA008XD4 | 250mg | $17 |
| 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine 98% | AA008XD4 | 1g | $21 |
| More product size | |||
| Boiling point | 313.6±42.0 °C(Predicted) |
|---|---|
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 2.80±0.22(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C12H15BF3NO2/c1-10(2)11(3,4)19-13(18-10)9-5-8(6-17-7-9)12(14,15)16/h5-7H,1-4H3 |
| InChIKey | LFZDWNHGQKQVIG-UHFFFAOYSA-N |
| SMILES | C1=NC=C(C(F)(F)F)C=C1B1OC(C)(C)C(C)(C)O1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P280 |
| HS Code | 2933399990 |
5-Trifluoromethylpyridine-3-boronic acid pinacol ester price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | T10602 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | 1084953-47-8 | 1g | $35 | 2026-05-06 | Buy |
| Synthonix | T10602 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | 1084953-47-8 | 5g | $140 | 2026-05-06 | Buy |
| Synthonix | T10602 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 97.0% | 1084953-47-8 | 10g | $260 | 2026-05-06 | Buy |
| aablocks | AA008XD4 | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine 98% | 1084953-47-8 | 250mg | $17 | 2026-05-28 | Buy |
| aablocks | AA008XD4 | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine 98% | 1084953-47-8 | 1g | $21 | 2026-05-28 | Buy |
5-Trifluoromethylpyridine-3-boronic acid pinacol ester Chemical Properties,Uses,Production
Application
5-Trifluoromethylpyridine-3-boronic acid pinacol ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.
Synthesis
73183-34-3
436799-33-6
1084953-47-8
The general procedure for the synthesis of 5-trifluoromethylpyridine-3-boronic acid pinacol ester from pinacol ester of biphenylboronic acid and 3-bromo-5-(trifluoromethyl)pyridine was as follows: 3.50 g (15.50 mmol) of 3-bromo-5-(trifluoromethyl)pyridine, 0.54 g (0.8 mmol) of bis(triphenylphosphine)palladium(II) chloride and 4.55 g (46.5 mmol) of potassium acetate were suspended in 75 mL of dioxane and stirred for 15 minutes. Subsequently, 6.42 g (24.8 mmol) of pinacol ester of bisboronic acid (4,4,5,5,4',4',5',5'-octamethyl-[2,2']bis[[1,3,2]dioxaborolane]) was added and the mixture was heated to 100 °C for 20 hours of reaction. Upon completion of the reaction, the mixture was poured into crushed ice, the pH was adjusted to 9-10 with sodium carbonate solution, and then extracted three times with ethyl acetate. The organic phases were combined, washed with water, dried over magnesium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (dichloromethane/methanol, 1:0 to 9:1) to give 3.48 g (82% yield) of 5-trifluoromethylpyridine-3-boronic acid pinacol ester as a colorless solid. Mass spectrum (MS): 273.1 (M+).
References
[1] Patent: US2009/48238, 2009, A1. Location in patent: Page/Page column 20
[2] Patent: WO2013/43521, 2013, A1. Location in patent: Page/Page column 38; 39
[3] Patent: EP2719697, 2014, A1. Location in patent: Paragraph 0210-0212
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0266
5-Trifluoromethylpyridine-3-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9072 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
View Lastest Price from 5-Trifluoromethylpyridine-3-boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
|
$1.00 | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
1084953-47-8
- $1.00
- 95%
- Career Henan Chemical Co
