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2,4,5-Trimethoxybenzaldehyde

2,4,5-Trimethoxybenzaldehyde structure

CAS No.: 4460-86-0

Chemical Name:: 2,4,5-Trimethoxybenzaldehyde

Synonyms: Asarylaldehyde;ASARALDEHYDE;Gazarin;Benzaldehyde, 2,4,5-trimethoxy-;ASARONALDEHYDE;NCI-C61632;Azarylaldehyde;2,4,5-Trimethoxy;AKOS BBS-00003175;Asarylaldehyde-RM

CBNumber:: CB3251399

Molecular Formula:: C10H12O4

Molecular Weight:: 196.2

MDL Number:: MFCD00003312

MOL File:: 4460-86-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Asarylaldehyde phyproof? Reference Substance	PHL82478	100mg	$247
2,4,5-Trimethoxybenzaldehyde 98%	132152	25g	$68.7
2,4,5-Trimethoxybenzaldehyde 98%	132152	100g	$130
2,4,5-Trimethoxybenzaldehyde >98.0%(GC)	T1172	5g	$17
2,4,5-Trimethoxybenzaldehyde >98.0%(GC)	T1172	25g	$46
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2,4,5-Trimethoxybenzaldehyde Properties

Melting point	112-114 °C (lit.)
Boiling point	140°C 4mm
Density	1.2166 (rough estimate)
refractive index	1.5550 (estimate)
Flash point	140°C/4mm subl.
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Fine Crystalline Powder
color	White to light beige
Water Solubility	<0.1 g/100 mL at 22 ºC
Sensitive	Air Sensitive
BRN	1951403
InChI	1S/C10H12O4/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-6H,1-3H3
InChIKey	IAJBQAYHSQIQRE-UHFFFAOYSA-N
SMILES	[H]C(=O)c1cc(OC)c(OC)cc1OC
LogP	1.634 (est)
CAS DataBase Reference	4460-86-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	NDU8J2Q00D
NIST Chemistry Reference	Benzaldehyde, 2,4,5-trimethoxy-(4460-86-0)
EPA Substance Registry System	2,4,5-Trimethoxybenzaldehyde (4460-86-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38-34

Safety Statements

22-24/25-45-36/37/39-27-26

WGK Germany

RTECS

CU8460000

TSCA

TSCA listed

HS Code

29124990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Hazardous Substances Data

4460-86-0(Hazardous Substances Data)

NFPA 704

	0
1		0

2,4,5-Trimethoxybenzaldehyde price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL82478	Asarylaldehyde phyproof? Reference Substance	4460-86-0	100mg	$247	2026-04-30	Buy
Sigma-Aldrich	132152	2,4,5-Trimethoxybenzaldehyde 98%	4460-86-0	25g	$68.7	2023-06-20	Buy
Sigma-Aldrich	132152	2,4,5-Trimethoxybenzaldehyde 98%	4460-86-0	100g	$130	2023-06-20	Buy
TCI Chemical	T1172	2,4,5-Trimethoxybenzaldehyde >98.0%(GC)	4460-86-0	5g	$17	2026-04-30	Buy
TCI Chemical	T1172	2,4,5-Trimethoxybenzaldehyde >98.0%(GC)	4460-86-0	25g	$46	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHL82478	100mg	$247	Buy
132152	25g	$68.7	Buy
132152	100g	$130	Buy
T1172	5g	$17	Buy
T1172	25g	$46	Buy

2,4,5-Trimethoxybenzaldehyde Chemical Properties,Uses,Production

Description

2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a natural cyclooxygenase-2 (COX-2) activity inhibitor that is present in carrot seeds (Daucus carota L.) and can be synthesised using Indonesia Sweet Flag (Acorus calamus) as a raw material. 2,4,5-TMBA may serve as a synthetic intermediate component for various pharmaceuticals. In addition, 2,4,5-TMBA is also considered a candidate drug for oral non-steroidal anti-inflammatory drugs (NSAIDs)^[1].
[1] LERRICK R I. Synthesis of Nonsteroidal Anti-Inflammatory Drug (NSAID) 2,4,5-Trimethoxybenzaldehyde from Indonesian Calamus oil and Its In Silico Pharmacokinetic Study[J]. Canadian Journal of Chemistry, 2022, 20 1. DOI:10.1139/cjc-2022-0121.

Chemical Properties

white to light beige fine crystalline powder

Uses

fly attractant

Uses

2,4,5-Trimethoxybenzaldehyde is used in the synthesis of stilbene and hydrostibene derivatives as potential anticancer agents, inhibiting tubulin. Also used in the synthesis of HIV-RT inhibitors.

Uses

A selective Cox-2 inhibitor.

Definition

ChEBI: 2,4,5-trimethoxybenzaldehyde is a carbonyl compound.

General Description

Beige powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4,5-Trimethoxybenzaldehyde is light sensitive. .

Health Hazard

SYMPTOMS: Symptoms of exposure to related compounds are skin and gastrointestinal tract irritation, sensitization, blistering, nausea, vomiting, diarrhea, urinary tract irritation, initial excitement, convulsions and central nervous system depression.

Fire Hazard

Flash point data for 2,4,5-Trimethoxybenzaldehyde are not available, but 2,4,5-Trimethoxybenzaldehyde is probably combustible.

Biological Activity

2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, leaves, and roots. 2,4,5-TMBA exhibits anti-inflammatory, anti-adipogenic, and immunomodulatory activities. 2,4,5-TMBA has significant inhibitory effects on COX-2 activity. COX-2 not only plays a crucial role in inflammatory reactions, but also participates in the adipogenesis of 3T3-L1 cells via its derivative 15-deoxy-D12,14 prostaglandin (PG)J2 (15d-PGJ2). Studies indicate that 2,4,5-TMBA further inhibits lipogenesis and promotes lipolysis in 3T3-L1 adipocytes. This is closely associated with 2,4,5-TMBA's downregulation of proteins critical for adipogenesis, including CCAAT/enhancer-binding proteins (C/EBP) α, β, δ, peroxisome proliferator-activated receptor (PPAR)γ2, acyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and perilipin A in preadipocytes. In addition, carrot seed extracts rich in 2,4,5-TMBA exhibit immunomodulatory activity.

2,4,5-Trimethoxybenzaldehyde synthesis

Synthesis of 2,4,5-Trimethoxybenzaldehyde from [(difluoromethyl)thio]benzene and 1,2,4-Trimethoxybenzene

2,4,5-Trimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone

Preparation Products

trans-2,4,5-Trimethoxycinnamic acid Scopoletin BETA-ASARONE alpha-Asarone 2,4,5-TRIMETHOXYAMPHETAMIN

oxidopamine

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2,4,5-Trimethoxybenzaldehyde Suppliers

Global( 554)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 2,4,5-Trimethoxybenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-27	2,4,5-Trimethoxybenzaldehyde 4460-86-0	US $0.00-0.00 / kg	1kg	98%	100tons	Shandong Vital Biotechnology Co., Ltd.
2026-04-22	Asaraldehyde 4460-86-0	US $29.00 / g		99.76%	10g	TargetMol Chemicals Inc.
2026-03-20	2,4,5-Trimethoxybenzaldehyde 4460-86-0	US $9.90 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

2,4,5-Trimethoxybenzaldehyde
4460-86-0
US $0.00-0.00 / kg
98%
Shandong Vital Biotechnology Co., Ltd.

Asaraldehyde
4460-86-0
US $29.00 / g
99.76%
TargetMol Chemicals Inc.

2,4,5-Trimethoxybenzaldehyde
4460-86-0
US $9.90 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2,4,5-Trimethoxybenzaldehyde Spectrum

2,4,5-Trimethoxybenzaldehyde(4460-86-0)MS 2,4,5-Trimethoxybenzaldehyde(4460-86-0)¹HNMR 2,4,5-Trimethoxybenzaldehyde(4460-86-0)¹³CNMR 2,4,5-Trimethoxybenzaldehyde(4460-86-0)IR1 2,4,5-Trimethoxybenzaldehyde(4460-86-0)IR2 2,4,5-Trimethoxybenzaldehyde(4460-86-0)Raman

4460-86-0(2,4,5-Trimethoxybenzaldehyde)Related Search:

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ASARONALDEHYDE ASARALDEHYDE Asarylaldehyde Azarylaldehyde Gazarin NCI-C61632 2,4,5-trimethyl ether 2,4,5-TRIMETHOXYBENZALDEHYDE 3,4,6-trimethoxybenzaldehyde AKOS BBS-00003175 2,4,5-trimethoxybenzaldehdye 2,4,5-Trimethoxy-benzaldehyd 2,4,5-Trimethoxybenzaldheyde 2,4,5-Trimethoxy 2.4.5-TRIMOTHOXYBENZALDEHYDE 2,4,5-TRIMETHOXYBENZALDEHYDE 98+% (GC) Benzaldehyde, 2,4,5-trimethoxy- 2,4,5-Trimethoxybenzaldehyde,98% 2,4,5-Trimethoxybenz 2,4,5-Trihydroxybenzaldehyde triMethyl ether 5-TriMethoxybenzaldehyde 2,4,5-TriMethoxybenzaldehyde, 98% 25GR Asaraldehyde (Asaronaldehyde) 2,4,5-TriMehoxybenzaldehdye 2,4,5-Trimethoxybenzaldehyde Vetec(TM) reagent grade, 98% 2,4,5-Trimethoxybenzaldehyde ASARONALDEHYDE 5-trimethoxy-Benzaldehyd Trimetazidine Impurity 10 2,4,5-Trimethoxybenzaldehyde, Asaronaldehyde, Asaraldehyde, Asarylaldehyde 2,4,5-TrimethoxybenzaL 2,4,5-Trimethoxybenzaldehyde 99% (Asaraldehyde) 2, 4, 5-Trimethoxybenzaldehyde CAS 4460-86-0 high quality Asaraldehyde:2.4.5-trimethoxy-Benzaldehyde 2,4,5-Trimethoxybenzaldehyde/Asaraldehyde 2,4,5-Trimethoxybenzaldehyde CAS Asarylaldehyde-RM Trimetazidine Impurity 42 4460-86-0 460-86-0 CH3O3C6H2CHO ALDEHYDE Organic Building Blocks Aldehydes Building Blocks Carbonyl Compounds C10 to C21 Inhibitors Aromatic Aldehydes & Derivatives (substituted) FINE Chemical & INTERMEDIATES bc0001