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ChemicalBook >> CAS DataBase List >>N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Structure
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide structure
CAS No.
839707-37-8
Chemical Name:
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Synonyms
CS-2160;CS-2337;Pluripotin;SC1 (Pluripotin);Pluripotin (SC-1);Pluripotin, 10 mM in DMSO;SC-1 (Pluripotin), Dual kinase and GTPase inhibitor;N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimid;inhibit,Extracellular signal regulated kinases,Ribosomal S6 Kinase (RSK),SC-1,SC 1,Inhibitor,ERK,S6K,Pluripotin;N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide
CBNumber:
CB32521089
Molecular Formula:
C27H25F3N8O2
Molecular Weight:
550.53
MDL Number:
MFCD20527253
MOL File:
839707-37-8.mol
Last updated:2026-02-02 18:10:39
Product description Number Pack Size Price
Pluripotin ≥98% (HPLC) SML0444 5mg $171.95
SC-1 ≥98% 10009557 1mg $57
SC-1 ≥98% 10009557 5mg $152
SC-1 ≥98% 10009557 10mg $275
SC-1 ≥98% 10009557 25mg $601
Request For Quotation

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Properties

Density 1.43
storage temp. -20°C
solubility DMSO: soluble10mg/mL (clear solution)
pka 12.82±0.70(Predicted)
form powder
color white to beige
InChIKey NBZFRTJWEIHFPF-UHFFFAOYSA-N
SMILES C(NC1=CC=C(C)C(N2C(=O)N(C)C3=NC(NC4N(C)N=C(C)C=4)=NC=C3C2)=C1)(=O)C1=CC=CC(C(F)(F)F)=C1
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352
Hazard Codes  T
Risk Statements  25
Safety Statements  45
WGK Germany  3
HS Code  2933399990
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0444 Pluripotin ≥98% (HPLC) 839707-37-8 5mg $171.95 2025-07-31 Buy
Cayman Chemical 10009557 SC-1 ≥98% 839707-37-8 1mg $57 2024-03-01 Buy
Cayman Chemical 10009557 SC-1 ≥98% 839707-37-8 5mg $152 2024-03-01 Buy
Cayman Chemical 10009557 SC-1 ≥98% 839707-37-8 10mg $275 2024-03-01 Buy
Cayman Chemical 10009557 SC-1 ≥98% 839707-37-8 25mg $601 2024-03-01 Buy
Product number Packaging Price Buy
SML0444 5mg $171.95 Buy
10009557 1mg $57 Buy
10009557 5mg $152 Buy
10009557 10mg $275 Buy
10009557 25mg $601 Buy

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Chemical Properties,Uses,Production

Uses

Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 μM, respectively.

Biological Activity

Pluripotin is an activator of murine embryonic stem (ES) cell self-renewal. It appears th at pluripotin mediates the activity by dual RasGAP and ERK1 inhibition.

IC 50

ERK1: 98 nM (Kd); RasGAP: 212 nM (Kd); RSK1: 0.5 μM (IC50); RSK2: 2.5 μM (IC50); RSK3: 3.3 μM (IC50); RSK4: 10 μM (IC50)

storage

-20°C

References

[1] Chen S, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. DOI:10.1073/pnas.0608156103
[2] Mertins SD, et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8(2):e57099. DOI:10.1371/journal.pone.0057099

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Suppliers

Global( 112)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 8497 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
BOC Sciences 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pluripotin pictures 2026-02-01 Pluripotin
839707-37-8
 US $30.00-61.00 / mg 98.77% 10g TargetMol Chemicals Inc.
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide pictures 2020-03-12 N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
839707-37-8
 US $1.00 / KG 100KG 99.0% 1000kg Career Henan Chemical Co
  • Pluripotin pictures
  • Pluripotin
    839707-37-8
  • US $30.00-61.00 / mg
  • 98.77%
  • TargetMol Chemicals Inc.

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Spectrum

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide(839707-37-8)1HNMR
SC1 (Pluripotin) N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimid N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide Pluripotin Pluripotin (SC-1) N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide CS-2337 CS-2160 N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide inhibit,Extracellular signal regulated kinases,Ribosomal S6 Kinase (RSK),SC-1,SC 1,Inhibitor,ERK,S6K,Pluripotin Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- SC-1 (Pluripotin), Dual kinase and GTPase inhibitor Pluripotin, 10 mM in DMSO 839707-37-8 C27H25F3N8O2 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals