METHYL 2-FLUORO-5-NITROBENZOATE
- CAS No.
- 2965-22-2
- Chemical Name:
- METHYL 2-FLUORO-5-NITROBENZOATE
- Synonyms
- RARECHEM AL BF 0280;METHYL 2-FLUORO-5-NITROBENZOATE;Methyl2-fluoro-5-nitrobenzoate,98%;4-Fluoro-3-(Methoxycarbonyl)nitrobenzene;5-nitro-2-fluorobenzoic acid methyl ester;methyl 2-fluoro-5-nitrobenzenecarboxylate;Benzoic acid, 2-fluoro-5-nitro-, methyl ester
- CBNumber:
- CB3256172
- Molecular Formula:
- C8H6FNO4
- Molecular Weight:
- 199.14
- MDL Number:
- MFCD06203689
- MOL File:
- 2965-22-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2-Fluoro-5-nitrobenzoate >98.0%(GC) | M3115 | 5g | $91 |
| Methyl 2-Fluoro-5-nitrobenzoate >98.0%(GC) | M3115 | 25g | $366 |
| Methyl 2-Fluoro-5-nitrobenzoate | M305570 | 250mg | $55 |
| Methyl 2-fluoro-5-nitrobenzenecarboxylate 95+% | 047966 | 5g | $19 |
| Methyl 2-fluoro-5-nitrobenzenecarboxylate 95+% | 047966 | 100g | $236 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
METHYL 2-FLUORO-5-NITROBENZOATE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3115 | Methyl 2-Fluoro-5-nitrobenzoate >98.0%(GC) | 2965-22-2 | 5g | $91 | 2025-07-31 | Buy |
| TCI Chemical | M3115 | Methyl 2-Fluoro-5-nitrobenzoate >98.0%(GC) | 2965-22-2 | 25g | $366 | 2025-07-31 | Buy |
| TRC | M305570 | Methyl 2-Fluoro-5-nitrobenzoate | 2965-22-2 | 250mg | $55 | 2021-12-16 | Buy |
| Matrix Scientific | 047966 | Methyl 2-fluoro-5-nitrobenzenecarboxylate 95+% | 2965-22-2 | 5g | $19 | 2021-12-16 | Buy |
| Matrix Scientific | 047966 | Methyl 2-fluoro-5-nitrobenzenecarboxylate 95+% | 2965-22-2 | 100g | $236 | 2021-12-16 | Buy |
METHYL 2-FLUORO-5-NITROBENZOATE Chemical Properties,Uses,Production
Synthesis
67-56-1
7304-32-7
2965-22-2
General procedure for the synthesis of methyl 2-fluoro-5-nitrobenzoate from methanol and 2-fluoro-5-nitrobenzoic acid: 1. dissolve 2-fluoro-5-nitrobenzoic acid (3.7 g, 20.0 mmol) in methanol (100 mL) at 0 °C. 2. Slowly add thionyl chloride (5.3 mL, 60.0 mmol) dropwise. 3. The reaction mixture was heated to reflux for 24 hours. 4. Upon completion of the reaction, the solvent was removed by vacuum concentration. 5. 5. The residue was dissolved in ethyl acetate and washed several times with 1.0 M NaOH solution. 6. The organic phase was dried with anhydrous sodium sulfate and the solvent was evaporated in vacuum to give the intermediate methyl 2-fluoro-5-nitrobenzoate (Intermediate 37) as a yellow oil, which crystallized into light yellow needle crystals after standing. Yield: 90%; Melting point: 47-49°C; 1H NMR (300MHz, CDCl3) δ= 4.01 (s, 3H, OCH3), 7.35 (t, 1H, H3,3JH3.H4 = 3JH3.F = 9.2Hz), 8.44 (dt, 1H, 3JH4-H3 = 9.2Hz, 4JH4.F = 4JH4-H6 = 3.5Hz), 8.87 (dd, 1H. 4JH6-F = 5.9 Hz, 4JH6-H4 = 2.7 Hz); 13C NMR (75 MHz, CDCl3): δ= 47.7 (OCH3), 113.2 (d, C3,2JC-F = 25.1 Hz), 114.5 (d, C1, 2JC-F = 12.0 Hz), 122.9 (d, C6,3JC-F = 3.3 Hz), 124.3 (d, C4,3JC-F = 10.9 Hz ), 138.6 (C5), 157.4 (d, COOCH3,3JC-F = 3.8 Hz), 159.8 (d, C2,1JC-F = 269.0 Hz).
References
[1] Patent: WO2012/85003, 2012, A1. Location in patent: Page/Page column 83-84
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4640 - 4660
[3] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0467
[4] Patent: WO2009/80836, 2009, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/92124, 2004, A2. Location in patent: Page 77
METHYL 2-FLUORO-5-NITROBENZOATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
View Lastest Price from METHYL 2-FLUORO-5-NITROBENZOATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co | |
|
|
2019-07-06 | METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co | |
|
|
2019-07-06 | METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
|
US $1.00 / KG | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
-
- METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
-
- METHYL 2-FLUORO-5-NITROBENZOATE
2965-22-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
